GLC Determination of Ibuprofen [(±)-2-(p-Isobutylphenyl)propionic Acid] in Plasma

GLC Determination of Ibuprofen [(±)-2-(p-Isobutylphenyl)propionic Acid] in Plasma

To evaluate the pharmacokinetics and drug availability from various dosage formulations, a method for the determination of ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] in human plasma was required. A simple, rapid, sensitive, and specific procedure, based on a benzene extraction of the acidifi...

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Veröffentlicht in:Journal of pharmaceutical sciences 1974-02, Vol.63 (2), p.219-221
Hauptverfasser: Kaiser, David G., Vangiessen, Garrett J.
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Sprache:eng
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(±)- 2-(p-Isobutylphenyl)propionic acid (ibuprofen)—GLC analysis in human plasma
GLC-analysis
GLC—analysis, ibuprofen in human plasma
ibuprofen in human plasma
Ibuprofen-GLC analysis in human plasma
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container_title Journal of pharmaceutical sciences
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creator Kaiser, David G.
Vangiessen, Garrett J.
description To evaluate the pharmacokinetics and drug availability from various dosage formulations, a method for the determination of ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] in human plasma was required. A simple, rapid, sensitive, and specific procedure, based on a benzene extraction of the acidified specimen and subsequent GLC analysis of the methyl esters of the extract residue, was developed. The method is sensitive to 0.5 μg ibuprofen/ml plasma. Statistical analyses indicate an average recovery of 94.8 ±6.6% (SD), which is adequate to differentiate assay error from normal biological variation. Mass spectrometric analysis, in conjunction with GLC, confirmed the specificity of the method for intact drug. The procedure was successfully applied to drug absorption studies in humans.
doi_str_mv 10.1002/jps.2600630208
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A simple, rapid, sensitive, and specific procedure, based on a benzene extraction of the acidified specimen and subsequent GLC analysis of the methyl esters of the extract residue, was developed. The method is sensitive to 0.5 μg ibuprofen/ml plasma. Statistical analyses indicate an average recovery of 94.8 ±6.6% (SD), which is adequate to differentiate assay error from normal biological variation. Mass spectrometric analysis, in conjunction with GLC, confirmed the specificity of the method for intact drug. 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Pharm. Sci</addtitle><description>To evaluate the pharmacokinetics and drug availability from various dosage formulations, a method for the determination of ibuprofen [(±)-2-(p-isobutylphenyl)propionic acid] in human plasma was required. A simple, rapid, sensitive, and specific procedure, based on a benzene extraction of the acidified specimen and subsequent GLC analysis of the methyl esters of the extract residue, was developed. The method is sensitive to 0.5 μg ibuprofen/ml plasma. Statistical analyses indicate an average recovery of 94.8 ±6.6% (SD), which is adequate to differentiate assay error from normal biological variation. Mass spectrometric analysis, in conjunction with GLC, confirmed the specificity of the method for intact drug. 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subjects (±)- 2-(p-Isobutylphenyl)propionic acid (ibuprofen)—GLC analysis in human plasma
GLC-analysis
GLC—analysis, ibuprofen in human plasma
ibuprofen in human plasma
Ibuprofen-GLC analysis in human plasma
title GLC Determination of Ibuprofen [(±)-2-(p-Isobutylphenyl)propionic Acid] in Plasma
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