Cardiovascular Effects of Digoxin—Phenelzine Interaction in Rabbits
The potential toxicity of combining phenelzine, an MAO inhibitor, and digoxin, a cardiac glycoside, was studied in rabbits. Cardiovascular responses following concurrent administration of these drugs and the administration of these drugs 20 and 60min. apart, respectively, revealed that phenelzine an...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1973-11, Vol.62 (11), p.1876-1878 |
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| container_end_page | 1878 |
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| container_issue | 11 |
| container_start_page | 1876 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 62 |
| creator | Bohrman, Jeffrey S. Thompson, Emmanuel B. |
| description | The potential toxicity of combining phenelzine, an MAO inhibitor, and digoxin, a cardiac glycoside, was studied in rabbits. Cardiovascular responses following concurrent administration of these drugs and the administration of these drugs 20 and 60min. apart, respectively, revealed that phenelzine and digoxin evoked arrhythmias in about 50% of all rabbits tested without markedly altering the arterial blood pressure. Spontaneous heart rate in these animals was found to be lower than control values. The incidence of arrhythmia decreased as the time interval between the administration of both drugs was increased from 20 to 60min. An increase in the number of days of pretreatment with phenelzine resulted in the use of a higher dose of digoxin to evoke arrhythmia. |
| doi_str_mv | 10.1002/jps.2600621132 |
| format | Article |
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Cardiovascular responses following concurrent administration of these drugs and the administration of these drugs 20 and 60min. apart, respectively, revealed that phenelzine and digoxin evoked arrhythmias in about 50% of all rabbits tested without markedly altering the arterial blood pressure. Spontaneous heart rate in these animals was found to be lower than control values. The incidence of arrhythmia decreased as the time interval between the administration of both drugs was increased from 20 to 60min. An increase in the number of days of pretreatment with phenelzine resulted in the use of a higher dose of digoxin to evoke arrhythmia.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600621132</identifier><identifier>PMID: 4758091</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; Arrhythmias, Cardiac - chemically induced ; Blood Pressure - drug effects ; Digoxin - antagonists & inhibitors ; Digoxin - pharmacology ; Digoxin-phendzine interactions-cardiovascular effects in rabbits ; Digoxin-phenelzine interactions cardiovascular effects in rabbits, dose-time relationships ; digoxin-phenelzine-cardiovascular effects in rabbits ; Digoxin‐phendzine interactions—cardiovascular effects in rabbits, dose‐time relationships ; dose-time relationships ; Drug Interactions ; Drug interactions digoxin-phenelzine in rabbits ; Female ; Heart Rate - drug effects ; Interactions ; Interactions, digoxin-phenelzine—cardiovascular effects in rabbits, dose-time relationships ; Phenelzine - pharmacology ; Phenelzine-digoxin interactions-cardiovascular effects in rabbits ; Phenelzine-digoxin interactions—cardiovascular effects in rabbits, dose -time relationships ; Rabbits ; Time Factors</subject><ispartof>Journal of pharmaceutical sciences, 1973-11, Vol.62 (11), p.1876-1878</ispartof><rights>1973 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1973 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4272-334bd6df4a60111554ea306626e7bd9741c904867bfb336cb4f8de47405dcc4e3</citedby><cites>FETCH-LOGICAL-c4272-334bd6df4a60111554ea306626e7bd9741c904867bfb336cb4f8de47405dcc4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600621132$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600621132$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4758091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bohrman, Jeffrey S.</creatorcontrib><creatorcontrib>Thompson, Emmanuel B.</creatorcontrib><title>Cardiovascular Effects of Digoxin—Phenelzine Interaction in Rabbits</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The potential toxicity of combining phenelzine, an MAO inhibitor, and digoxin, a cardiac glycoside, was studied in rabbits. Cardiovascular responses following concurrent administration of these drugs and the administration of these drugs 20 and 60min. apart, respectively, revealed that phenelzine and digoxin evoked arrhythmias in about 50% of all rabbits tested without markedly altering the arterial blood pressure. Spontaneous heart rate in these animals was found to be lower than control values. The incidence of arrhythmia decreased as the time interval between the administration of both drugs was increased from 20 to 60min. An increase in the number of days of pretreatment with phenelzine resulted in the use of a higher dose of digoxin to evoke arrhythmia.</description><subject>Animals</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Blood Pressure - drug effects</subject><subject>Digoxin - antagonists & inhibitors</subject><subject>Digoxin - pharmacology</subject><subject>Digoxin-phendzine interactions-cardiovascular effects in rabbits</subject><subject>Digoxin-phenelzine interactions cardiovascular effects in rabbits, dose-time relationships</subject><subject>digoxin-phenelzine-cardiovascular effects in rabbits</subject><subject>Digoxin‐phendzine interactions—cardiovascular effects in rabbits, dose‐time relationships</subject><subject>dose-time relationships</subject><subject>Drug Interactions</subject><subject>Drug interactions digoxin-phenelzine in rabbits</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Interactions</subject><subject>Interactions, digoxin-phenelzine—cardiovascular effects in rabbits, dose-time relationships</subject><subject>Phenelzine - pharmacology</subject><subject>Phenelzine-digoxin interactions-cardiovascular effects in rabbits</subject><subject>Phenelzine-digoxin interactions—cardiovascular effects in rabbits, dose -time relationships</subject><subject>Rabbits</subject><subject>Time Factors</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EKuWxZYeUH0ixEz-SJSqlgHgJiip1Yzn2BAwlqewALSs-gi_kSzBKBWKBWM1izr2aOQjtENwjGCd79zPfSzjGPCEkTVZQl7AExxwTsYq6AUjilNF8HW14f48DhhnroA4VLMM56aJBXzlj62fl9dNUuWhQlqAbH9VldGBv67mtPt7eL--ggumrrSA6rhpwSje2riJbRVeqKGzjt9BaqaYetpdzE90cDkb9o_j0Ynjc3z-NNU1EuCSlheGmpCrcRwhjFFSKOU84iMLkghKdY5pxUZRFmnJd0DIzQAXFzGhNId1EvbZXu9p7B6WcOfuo3EISLL90yKBD_ugIgd02MHsqHsF848v_wz5v9y92Cot_2uTJ5fWv7rjNWt_A_Dur3IPkIhVMjs-Hkp-NTyajUSYngc9aHoKhZwtOem2h0mCsC86lqe1fb3wCnY2Ohw</recordid><startdate>197311</startdate><enddate>197311</enddate><creator>Bohrman, Jeffrey S.</creator><creator>Thompson, Emmanuel B.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197311</creationdate><title>Cardiovascular Effects of Digoxin—Phenelzine Interaction in Rabbits</title><author>Bohrman, Jeffrey S. ; Thompson, Emmanuel B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4272-334bd6df4a60111554ea306626e7bd9741c904867bfb336cb4f8de47405dcc4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Animals</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Blood Pressure - drug effects</topic><topic>Digoxin - antagonists & inhibitors</topic><topic>Digoxin - pharmacology</topic><topic>Digoxin-phendzine interactions-cardiovascular effects in rabbits</topic><topic>Digoxin-phenelzine interactions cardiovascular effects in rabbits, dose-time relationships</topic><topic>digoxin-phenelzine-cardiovascular effects in rabbits</topic><topic>Digoxin‐phendzine interactions—cardiovascular effects in rabbits, dose‐time relationships</topic><topic>dose-time relationships</topic><topic>Drug Interactions</topic><topic>Drug interactions digoxin-phenelzine in rabbits</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Interactions</topic><topic>Interactions, digoxin-phenelzine—cardiovascular effects in rabbits, dose-time relationships</topic><topic>Phenelzine - pharmacology</topic><topic>Phenelzine-digoxin interactions-cardiovascular effects in rabbits</topic><topic>Phenelzine-digoxin interactions—cardiovascular effects in rabbits, dose -time relationships</topic><topic>Rabbits</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bohrman, Jeffrey S.</creatorcontrib><creatorcontrib>Thompson, Emmanuel B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bohrman, Jeffrey S.</au><au>Thompson, Emmanuel B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Effects of Digoxin—Phenelzine Interaction in Rabbits</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1973-11</date><risdate>1973</risdate><volume>62</volume><issue>11</issue><spage>1876</spage><epage>1878</epage><pages>1876-1878</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The potential toxicity of combining phenelzine, an MAO inhibitor, and digoxin, a cardiac glycoside, was studied in rabbits. Cardiovascular responses following concurrent administration of these drugs and the administration of these drugs 20 and 60min. apart, respectively, revealed that phenelzine and digoxin evoked arrhythmias in about 50% of all rabbits tested without markedly altering the arterial blood pressure. Spontaneous heart rate in these animals was found to be lower than control values. The incidence of arrhythmia decreased as the time interval between the administration of both drugs was increased from 20 to 60min. An increase in the number of days of pretreatment with phenelzine resulted in the use of a higher dose of digoxin to evoke arrhythmia.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>4758091</pmid><doi>10.1002/jps.2600621132</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1973-11, Vol.62 (11), p.1876-1878 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jps_2600621132 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Animals Arrhythmias, Cardiac - chemically induced Blood Pressure - drug effects Digoxin - antagonists & inhibitors Digoxin - pharmacology Digoxin-phendzine interactions-cardiovascular effects in rabbits Digoxin-phenelzine interactions cardiovascular effects in rabbits, dose-time relationships digoxin-phenelzine-cardiovascular effects in rabbits Digoxin‐phendzine interactions—cardiovascular effects in rabbits, dose‐time relationships dose-time relationships Drug Interactions Drug interactions digoxin-phenelzine in rabbits Female Heart Rate - drug effects Interactions Interactions, digoxin-phenelzine—cardiovascular effects in rabbits, dose-time relationships Phenelzine - pharmacology Phenelzine-digoxin interactions-cardiovascular effects in rabbits Phenelzine-digoxin interactions—cardiovascular effects in rabbits, dose -time relationships Rabbits Time Factors |
| title | Cardiovascular Effects of Digoxin—Phenelzine Interaction in Rabbits |
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