Characterization of Adjuvant Mineral Oils
Analysis of two lots of mineral oil indicated the overall composition to be quite similar with two major hydrocarbon ranges: a low range from C14 to C20 with a maximum at C16 and a high range from C20 to C30 with a maximum at C25. The low range components represented 40.8 and 49.3 wt. % of Lots Q-9...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1972-08, Vol.61 (8), p.1292-1296 |
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| container_end_page | 1296 |
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| container_issue | 8 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 61 |
| creator | O'Neill, H.J. Yamauchi, T.N. Cohen, P. Hardegree, M.C. |
| description | Analysis of two lots of mineral oil indicated the overall composition to be quite similar with two major hydrocarbon ranges: a low range from C14 to C20 with a maximum at C16 and a high range from C20 to C30 with a maximum at C25. The low range components represented 40.8 and 49.3 wt. % of Lots Q-9 and Q-10, respectively. Urea fractionation of the paraffin-naphthene fraction from silica gel chromatography yielded 28.2 and 28.8 wt. % for Lots Q-9 and Q-10, respectively. The nonadductable material consisted of highly branched and cyclic structures containing up to four-ring systems. The total butyl phthalate content in Lots Q-9 and Q-10 was 13.2 and 7.0 p.p.m., respectively, with the ratio of mono-butyl phthalate to dibutyl phthalate being 9:1. No evidence was found to indicate the presence of polynuclear aromatic hydrocarbons. |
| doi_str_mv | 10.1002/jps.2600610825 |
| format | Article |
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The low range components represented 40.8 and 49.3 wt. % of Lots Q-9 and Q-10, respectively. Urea fractionation of the paraffin-naphthene fraction from silica gel chromatography yielded 28.2 and 28.8 wt. % for Lots Q-9 and Q-10, respectively. The nonadductable material consisted of highly branched and cyclic structures containing up to four-ring systems. The total butyl phthalate content in Lots Q-9 and Q-10 was 13.2 and 7.0 p.p.m., respectively, with the ratio of mono-butyl phthalate to dibutyl phthalate being 9:1. No evidence was found to indicate the presence of polynuclear aromatic hydrocarbons.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600610825</identifier><identifier>PMID: 5050379</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Absorption ; Adjuvant mineral oils-separation ; Adjuvant mineral oils—separation, UV and mass spectrometry characterization ; adjuvant-separation ; Carcinogens ; Chemistry Techniques, Analytical ; Chromatography ; Chromatography, Gas ; GC-separation of mineral oil components ; Hydrocarbons ; Mass Spectrometry ; Mass spectroscopy-characterization of mineral oils ; Mineral Oil ; Mineral oils ; Mineral oils, adjuvant—separation, UV and mass spectrometry characterization ; Pharmaceutic Aids ; Phthalate esters-identification in adjuvant mineral oils ; Ultraviolet Rays ; UV and mass spectrometry characterization ; UV spectrophotometry-characterization of mineral oils</subject><ispartof>Journal of pharmaceutical sciences, 1972-08, Vol.61 (8), p.1292-1296</ispartof><rights>2015 Wiley Periodicals, Inc. and the American Pharmacists Association</rights><rights>Copyright © 1972 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4275-55a27f8df71d512c21ed09cf96adf3a49da5dbde85b3a1aa1d0d4700c7017263</citedby><cites>FETCH-LOGICAL-c4275-55a27f8df71d512c21ed09cf96adf3a49da5dbde85b3a1aa1d0d4700c7017263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600610825$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600610825$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5050379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Neill, H.J.</creatorcontrib><creatorcontrib>Yamauchi, T.N.</creatorcontrib><creatorcontrib>Cohen, P.</creatorcontrib><creatorcontrib>Hardegree, M.C.</creatorcontrib><title>Characterization of Adjuvant Mineral Oils</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Analysis of two lots of mineral oil indicated the overall composition to be quite similar with two major hydrocarbon ranges: a low range from C14 to C20 with a maximum at C16 and a high range from C20 to C30 with a maximum at C25. The low range components represented 40.8 and 49.3 wt. % of Lots Q-9 and Q-10, respectively. Urea fractionation of the paraffin-naphthene fraction from silica gel chromatography yielded 28.2 and 28.8 wt. % for Lots Q-9 and Q-10, respectively. The nonadductable material consisted of highly branched and cyclic structures containing up to four-ring systems. The total butyl phthalate content in Lots Q-9 and Q-10 was 13.2 and 7.0 p.p.m., respectively, with the ratio of mono-butyl phthalate to dibutyl phthalate being 9:1. No evidence was found to indicate the presence of polynuclear aromatic hydrocarbons.</description><subject>Absorption</subject><subject>Adjuvant mineral oils-separation</subject><subject>Adjuvant mineral oils—separation, UV and mass spectrometry characterization</subject><subject>adjuvant-separation</subject><subject>Carcinogens</subject><subject>Chemistry Techniques, Analytical</subject><subject>Chromatography</subject><subject>Chromatography, Gas</subject><subject>GC-separation of mineral oil components</subject><subject>Hydrocarbons</subject><subject>Mass Spectrometry</subject><subject>Mass spectroscopy-characterization of mineral oils</subject><subject>Mineral Oil</subject><subject>Mineral oils</subject><subject>Mineral oils, adjuvant—separation, UV and mass spectrometry characterization</subject><subject>Pharmaceutic Aids</subject><subject>Phthalate esters-identification in adjuvant mineral oils</subject><subject>Ultraviolet Rays</subject><subject>UV and mass spectrometry characterization</subject><subject>UV spectrophotometry-characterization of mineral oils</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9PwjAUxxujQUSv3kx29TB87fbW7UiIoAbFRBKOTWm7WBwbaYeKf70jIxgPxtM7fH-893mEXFLoUwB2s1z7PksAEgopwyPSpcggTIDyY9JtDCyMMM5OyZn3S2hsgNghHQSEiGddcj18lU6q2jj7JWtblUGVBwO93LzLsg4ebWmcLIKpLfw5Ocll4c3FfvbIbHQ7G96Fk-n4fjiYhCpmHENEyXie6pxTjZQpRo2GTOVZInUeyTjTEvVCmxQXkaRSUg065gCKNyezJOqRflurXOW9M7lYO7uSbisoiB2xaIjFD3ETuGoD681iZfTBvkds9KzVP2xhtv-0iYfnl1_dYZu1vjafh6x0byLhEUcxfxqLIVI6H0EqdrvS1m-aB71b44RX1pTKaOuMqoWu7F8Y3xRjgtk</recordid><startdate>197208</startdate><enddate>197208</enddate><creator>O'Neill, H.J.</creator><creator>Yamauchi, T.N.</creator><creator>Cohen, P.</creator><creator>Hardegree, M.C.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197208</creationdate><title>Characterization of Adjuvant Mineral Oils</title><author>O'Neill, H.J. ; Yamauchi, T.N. ; Cohen, P. ; Hardegree, M.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4275-55a27f8df71d512c21ed09cf96adf3a49da5dbde85b3a1aa1d0d4700c7017263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Absorption</topic><topic>Adjuvant mineral oils-separation</topic><topic>Adjuvant mineral oils—separation, UV and mass spectrometry characterization</topic><topic>adjuvant-separation</topic><topic>Carcinogens</topic><topic>Chemistry Techniques, Analytical</topic><topic>Chromatography</topic><topic>Chromatography, Gas</topic><topic>GC-separation of mineral oil components</topic><topic>Hydrocarbons</topic><topic>Mass Spectrometry</topic><topic>Mass spectroscopy-characterization of mineral oils</topic><topic>Mineral Oil</topic><topic>Mineral oils</topic><topic>Mineral oils, adjuvant—separation, UV and mass spectrometry characterization</topic><topic>Pharmaceutic Aids</topic><topic>Phthalate esters-identification in adjuvant mineral oils</topic><topic>Ultraviolet Rays</topic><topic>UV and mass spectrometry characterization</topic><topic>UV spectrophotometry-characterization of mineral oils</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Neill, H.J.</creatorcontrib><creatorcontrib>Yamauchi, T.N.</creatorcontrib><creatorcontrib>Cohen, P.</creatorcontrib><creatorcontrib>Hardegree, M.C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Neill, H.J.</au><au>Yamauchi, T.N.</au><au>Cohen, P.</au><au>Hardegree, M.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Adjuvant Mineral Oils</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1972-08</date><risdate>1972</risdate><volume>61</volume><issue>8</issue><spage>1292</spage><epage>1296</epage><pages>1292-1296</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Analysis of two lots of mineral oil indicated the overall composition to be quite similar with two major hydrocarbon ranges: a low range from C14 to C20 with a maximum at C16 and a high range from C20 to C30 with a maximum at C25. The low range components represented 40.8 and 49.3 wt. % of Lots Q-9 and Q-10, respectively. Urea fractionation of the paraffin-naphthene fraction from silica gel chromatography yielded 28.2 and 28.8 wt. % for Lots Q-9 and Q-10, respectively. The nonadductable material consisted of highly branched and cyclic structures containing up to four-ring systems. The total butyl phthalate content in Lots Q-9 and Q-10 was 13.2 and 7.0 p.p.m., respectively, with the ratio of mono-butyl phthalate to dibutyl phthalate being 9:1. No evidence was found to indicate the presence of polynuclear aromatic hydrocarbons.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5050379</pmid><doi>10.1002/jps.2600610825</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1972-08, Vol.61 (8), p.1292-1296 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Absorption Adjuvant mineral oils-separation Adjuvant mineral oils—separation, UV and mass spectrometry characterization adjuvant-separation Carcinogens Chemistry Techniques, Analytical Chromatography Chromatography, Gas GC-separation of mineral oil components Hydrocarbons Mass Spectrometry Mass spectroscopy-characterization of mineral oils Mineral Oil Mineral oils Mineral oils, adjuvant—separation, UV and mass spectrometry characterization Pharmaceutic Aids Phthalate esters-identification in adjuvant mineral oils Ultraviolet Rays UV and mass spectrometry characterization UV spectrophotometry-characterization of mineral oils |
| title | Characterization of Adjuvant Mineral Oils |
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