Preliminary Pharmacology of Ellagic Acid From Juglans nigra (Black Walnut)
A crystalline compound was isolated from Juglans nigra which by comparison with the known compound was found to be ellagic acid. The ellagic acid injected (i.p.) produced significant sedation, ataxia, potentiated sodium pentobarbital sleeping time, and protected mice from death after electroconvulsi...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1968-10, Vol.57 (10), p.1728-1732 |
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| container_end_page | 1732 |
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| container_issue | 10 |
| container_start_page | 1728 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 57 |
| creator | Bhargava, U.C. Westfall, B.A. Siehr, D.J. |
| description | A crystalline compound was isolated from Juglans nigra which by comparison with the known compound was found to be ellagic acid. The ellagic acid injected (i.p.) produced significant sedation, ataxia, potentiated sodium pentobarbital sleeping time, and protected mice from death after electroconvulsive shock. Intravenous injection of ellagic acid caused a fall in blood pressure and an elevation of the T wave, whereas the heart and respiration rate initially increased followed by a decrease. The ellagic acid produced no significant effect on isolated duodenal and uterus segments of the rat. |
| doi_str_mv | 10.1002/jps.2600571021 |
| format | Article |
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The ellagic acid injected (i.p.) produced significant sedation, ataxia, potentiated sodium pentobarbital sleeping time, and protected mice from death after electroconvulsive shock. Intravenous injection of ellagic acid caused a fall in blood pressure and an elevation of the T wave, whereas the heart and respiration rate initially increased followed by a decrease. The ellagic acid produced no significant effect on isolated duodenal and uterus segments of the rat.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600571021</identifier><identifier>PMID: 5693427</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; Anticonvulsants - pharmacology ; Ataxia - chemically induced ; Benzopyrans - pharmacology ; Blood Pressure - drug effects ; Duodenum - drug effects ; Electroshock - adverse effects ; Ellagic acid-Juglans nigra ; Female ; Heart Rate - drug effects ; Hypnotics and Sedatives - pharmacology ; Hypotension - chemically induced ; IR spectrophotometry-identity ; Male ; Mice ; Nuts ; Pentobarbital - pharmacology ; Pharmacologic screening-ellagic acid ; Rats ; Respiration - drug effects ; Shock - mortality ; Uterus - drug effects ; UV spectrophotometry-identity</subject><ispartof>Journal of pharmaceutical sciences, 1968-10, Vol.57 (10), p.1728-1732</ispartof><rights>1968 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4931-9d22de55e92407aa06ee9e400572e4e34877319402f0534af0c2c77865a3ad713</citedby><cites>FETCH-LOGICAL-c4931-9d22de55e92407aa06ee9e400572e4e34877319402f0534af0c2c77865a3ad713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600571021$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600571021$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5693427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhargava, U.C.</creatorcontrib><creatorcontrib>Westfall, B.A.</creatorcontrib><creatorcontrib>Siehr, D.J.</creatorcontrib><title>Preliminary Pharmacology of Ellagic Acid From Juglans nigra (Black Walnut)</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A crystalline compound was isolated from Juglans nigra which by comparison with the known compound was found to be ellagic acid. The ellagic acid injected (i.p.) produced significant sedation, ataxia, potentiated sodium pentobarbital sleeping time, and protected mice from death after electroconvulsive shock. Intravenous injection of ellagic acid caused a fall in blood pressure and an elevation of the T wave, whereas the heart and respiration rate initially increased followed by a decrease. The ellagic acid produced no significant effect on isolated duodenal and uterus segments of the rat.</description><subject>Animals</subject><subject>Anticonvulsants - pharmacology</subject><subject>Ataxia - chemically induced</subject><subject>Benzopyrans - pharmacology</subject><subject>Blood Pressure - drug effects</subject><subject>Duodenum - drug effects</subject><subject>Electroshock - adverse effects</subject><subject>Ellagic acid-Juglans nigra</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Hypotension - chemically induced</subject><subject>IR spectrophotometry-identity</subject><subject>Male</subject><subject>Mice</subject><subject>Nuts</subject><subject>Pentobarbital - pharmacology</subject><subject>Pharmacologic screening-ellagic acid</subject><subject>Rats</subject><subject>Respiration - drug effects</subject><subject>Shock - mortality</subject><subject>Uterus - drug effects</subject><subject>UV spectrophotometry-identity</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEUhS1EFQJl2x2Sl7CY9Po1zixpFB6jqI0KFUvL9dxJHTwzkZ205N8zaBCoi6qruzgP3fMR8onBhAHwz-tNmvAcQGkGnB2QMVMcshyYPiTj3sAzoWRxRI5TWgNADkqNyEjlhZBcj0m5jBh841sb93T5y8bGui50qz3tajoPwa68o5fOV_Qqdg0td6tg20Rbv4qWnn8J1j3SBxva3fbiI_lQ25Dw9PWekB9X8_vZTbb4dn07u1xkThaCZUXFeYVKYcElaGshRyxQvizgKFHIqdaCFRJ4DUpIW4PjTutprqywlWbihEyGXhe7lCLWZhN90_9vGJgXJqZnYt6Z9IGzIbDZ_WywerO_Quj1YtD_-ID7_7SZcnn3V3c2ZH3a4tNb1sZHk2uhlXn4em3up98Xpborjez908GPPaHfHqNJzmPrsPIR3dZUnf_XjGf-iY1E</recordid><startdate>196810</startdate><enddate>196810</enddate><creator>Bhargava, U.C.</creator><creator>Westfall, B.A.</creator><creator>Siehr, D.J.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196810</creationdate><title>Preliminary Pharmacology of Ellagic Acid From Juglans nigra (Black Walnut)</title><author>Bhargava, U.C. ; Westfall, B.A. ; Siehr, D.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4931-9d22de55e92407aa06ee9e400572e4e34877319402f0534af0c2c77865a3ad713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Animals</topic><topic>Anticonvulsants - pharmacology</topic><topic>Ataxia - chemically induced</topic><topic>Benzopyrans - pharmacology</topic><topic>Blood Pressure - drug effects</topic><topic>Duodenum - drug effects</topic><topic>Electroshock - adverse effects</topic><topic>Ellagic acid-Juglans nigra</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Hypotension - chemically induced</topic><topic>IR spectrophotometry-identity</topic><topic>Male</topic><topic>Mice</topic><topic>Nuts</topic><topic>Pentobarbital - pharmacology</topic><topic>Pharmacologic screening-ellagic acid</topic><topic>Rats</topic><topic>Respiration - drug effects</topic><topic>Shock - mortality</topic><topic>Uterus - drug effects</topic><topic>UV spectrophotometry-identity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhargava, U.C.</creatorcontrib><creatorcontrib>Westfall, B.A.</creatorcontrib><creatorcontrib>Siehr, D.J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhargava, U.C.</au><au>Westfall, B.A.</au><au>Siehr, D.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary Pharmacology of Ellagic Acid From Juglans nigra (Black Walnut)</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1968-10</date><risdate>1968</risdate><volume>57</volume><issue>10</issue><spage>1728</spage><epage>1732</epage><pages>1728-1732</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A crystalline compound was isolated from Juglans nigra which by comparison with the known compound was found to be ellagic acid. The ellagic acid injected (i.p.) produced significant sedation, ataxia, potentiated sodium pentobarbital sleeping time, and protected mice from death after electroconvulsive shock. Intravenous injection of ellagic acid caused a fall in blood pressure and an elevation of the T wave, whereas the heart and respiration rate initially increased followed by a decrease. The ellagic acid produced no significant effect on isolated duodenal and uterus segments of the rat.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5693427</pmid><doi>10.1002/jps.2600571021</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1968-10, Vol.57 (10), p.1728-1732 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Anticonvulsants - pharmacology Ataxia - chemically induced Benzopyrans - pharmacology Blood Pressure - drug effects Duodenum - drug effects Electroshock - adverse effects Ellagic acid-Juglans nigra Female Heart Rate - drug effects Hypnotics and Sedatives - pharmacology Hypotension - chemically induced IR spectrophotometry-identity Male Mice Nuts Pentobarbital - pharmacology Pharmacologic screening-ellagic acid Rats Respiration - drug effects Shock - mortality Uterus - drug effects UV spectrophotometry-identity |
| title | Preliminary Pharmacology of Ellagic Acid From Juglans nigra (Black Walnut) |
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