Impact of membrane properties on uptake and transcytosis of colloidal nanocarriers across an epithelial cell barrier model

The aim of this study was to investigate the effect of liposomal membrane properties on cellular uptake and transcytosis across a tight Madin–Darby canine kidney (MDCK) cell barrier in vitro. More than 25 small vesicles were prepared by lipid film hydration/extrusion to generate small unilamellar ve...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2010-05, Vol.99 (5), p.2423-2433
Hauptverfasser:	Orthmann, Andrea, Zeisig, Reiner, Koklič, Tilen, Šentjurc, Marjeta, Wiesner, Burkhard, Lemm, Margit, Fichtner, Iduna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport Cell Line Cell Membrane - drug effects Cell Membrane - metabolism cellular uptake Dogs Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Compounding electron paramagnetic resonance Electron Spin Resonance Spectroscopy Epithelial Cells - drug effects Epithelial Cells - metabolism Fluoresceins - administration & dosage Fluorescent Dyes - administration & dosage General pharmacology helper lipid liposomes MDCK cells Medical sciences Membrane Fluidity Microscopy, Confocal Microscopy, Fluorescence Nanoparticles - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments transcytosis Unilamellar Liposomes - chemistry Unilamellar Liposomes - pharmacokinetics
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