A Site-Directed Mutagenesis Study of Drug-Binding Selectivity in Genetic Variants of Human α1-Acid Glycoprotein

Human α1-acid glycoprotein (AGP), a major carrier of many basic drugs in circulation, consists of at least two genetic variants, namely A and F1*S variant. Interestingly, the variants of AGP have different drug-binding properties. The purpose of this study was to identify the amino acid residues tha...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2009-11, Vol.98 (11), p.4316-4326
Hauptverfasser:	Nishi, Koji, Ueno, Megumi, Murakami, Yuka, Fukunaga, Naoko, Akuta, Teruo, Kadowaki, Daisuke, Watanabe, Hiroshi, Suenaga, Ayaka, Maruyama, Toru, Otagiri, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-acid glycoprotein Biological and medical sciences drug transport General pharmacology glycoprotein Medical sciences Pharmaceutical technology. Pharmaceutical industry pharmacokinetics/pharmacodynamics Pharmacology. Drug treatments protein binding protein structure proteins
Online-Zugang:	Volltext
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