Effect of Fruit Juices on the Oral Bioavailability of Fexofenadine in Rats

Fexofenadine has been identified as a substrate for both the efflux transporter, P-glycoprotein (P-gp), as well as the influx transporter, organic anion transporting polypeptide (OATP). Clinical studies in humans showed that fruit juices reduced the oral bioavailability of fexofenadine by preferenti...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2005-02, Vol.94 (2), p.233-239
Hauptverfasser:	Kamath, Amrita V., Yao, Ming, Zhang, Yueping, Chong, Saeho
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals API Area Under Curve area under the concentration vs. time curve from 0 to time of the last measurable concentration atmospheric pressure ionization ATP Binding Cassette Transporter, Sub-Family B - metabolism AUC0n Beverages - adverse effects bioavailability Biological and medical sciences Biological Availability Citrus Cmax food interactions Food-Drug Interactions - physiology Fruit gastrointestinal tract General pharmacology GIT Histamine H1 Antagonists - pharmacokinetics internal standard Intestinal Absorption Male Malus maximum concentration Medical sciences MRP2 multidrug resistance-associated protein 2 OATP oral absorption Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - metabolism organic anion transporting polypeptide p-glycoprotein P-gp PEPT1 peptide transporter 1 Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Terfenadine - analogs & derivatives Terfenadine - pharmacokinetics time to reach Cmax Tmax transporters
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