Colon-Specific Prodrugs of 5-Aminosalicylic Acid: Synthesis and In Vitro/In Vivo Properties of Acidic Amino Acid Derivatives of 5-Aminosalicylic Acid

5-Aminosalicyl-L-aspartic acid (5-ASA-Asp) and 5-aminosalicyl-L-glutamic acid (5-ASA-Glu) were synthesized and their properties as colon-specific prodrugs of 5-aminosalicylic acid (5-ASA) were investigated employing rats as test animals. Incubation of 5-ASA-Asp and 5-ASA-Glu with the homogenates of...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2001-11, Vol.90 (11), p.1767-1775
Hauptverfasser:	Jung, Yun Jin, Lee, Jeoung Soo, Kim, Young Mi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aminosalicyl-L-aspartic acid 5-aminosalicyl-L-glutamic acid Administration, Oral Amino Acids, Acidic - blood Amino Acids, Acidic - chemical synthesis Amino Acids, Acidic - pharmacokinetics Amino Acids, Acidic - urine Animals Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - urine Biological and medical sciences Colon - metabolism colon-specific prodrug of 5-aminosalicylic acid Digestive system Feces - chemistry Gastric Mucosa - metabolism inflammatory bowel disease Injections, Intravenous Intestine, Small - metabolism Male Medical sciences Mesalamine - blood Mesalamine - chemical synthesis Mesalamine - pharmacokinetics Mesalamine - urine Pharmacology. Drug treatments Prodrugs - chemical synthesis Prodrugs - pharmacokinetics Rats Rats, Sprague-Dawley
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