Effects of Glucose on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats with Acute Renal Failure Induced by Uranyl Nitrate

The effects of glucose on CYP2E1 expression in rats with acute renal failure induced by uranyl nitrate (U-ARF) have been reported. CYP2E1 was significantly induced (2.3-fold) in rats with U-ARF compared with that in control rats. In contrast, CYP2E1 expression was significantly decreased in rats wit...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2003-08, Vol.92 (8), p.1604-1613
Hauptverfasser:	Ahn, Choong Y., Kim, Eun J., Lee, Inchul, Kwon, Jong W., Kim, Won B., Kim, Sang G., Lee, Myung G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - metabolism Animals Biological and medical sciences Chlorzoxazone - administration & dosage Chlorzoxazone - pharmacokinetics CZX Drug Interactions - physiology glucose Glucose - pharmacology Infusions, Intravenous Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - metabolism Muscle OH-CZX pharmacokinetics Pharmacology. Drug treatments Rats Rats, Sprague-Dawley U-ARF Uranyl Nitrate - toxicity
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