A Bayesian Method for Predicting 5‐Fluorouracil Pharmacokinetic Parameters Following Short‐Term Infusion in Patients With Colorectal Cancer

The objective of this study was to develop a population pharmacokinetic model and validate it using a Bayesian approach for predicting, a priori and a posteriori, the individual volume of distribution (Vd) and clearance (Cl) of 5‐fluorouracil (5‐FU) given as short‐term intravenous infusion in weekly...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2003-06, Vol.92 (6), p.1155-1165
Hauptverfasser:	Climente‐Martí, M., Merino‐Sanjuán, M., Almenar‐Cubells, D., Jiménez‐Torres, N.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil Adult Aged Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - blood Antimetabolites, Antineoplastic - pharmacokinetics Antineoplastic agents Area Under Curve Bayes Theorem Biological and medical sciences Chemotherapy colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Drug Administration Schedule Female Fluorouracil - administration & dosage Fluorouracil - blood Fluorouracil - pharmacokinetics Humans Infusions, Intravenous Male Medical sciences Middle Aged Models, Biological NONMEM pharmacokinetics Pharmacology. Drug treatments
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