Solubilization of Hydrophobic Drugs in Octanoyl‐6‐O‐Ascorbic Acid Micellar Dispersions

Alkanoyl‐6‐O‐ascorbic acid esters are easily obtained from vitamin C, and produce self‐assembled aggregates in water solutions, with an inner hydrophobic pool surrounded by an external hydrophilic shell. Compared to ascorbic acid, their solubility in oils and fats is greatly enhanced, while the pecu...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2002-08, Vol.91 (8), p.1810-1816
Hauptverfasser:	Palma, Santiago, Manzo, Ruben Hilario, Allemandi, Daniel, Fratoni, Laura, Lo Nostro, Pierandrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - chemistry Ascorbic Acid - analogs & derivatives Ascorbic Acid - chemistry ascorbic acid ester(s) Biological and medical sciences Biphenyl Compounds Chemical Phenomena Chemistry, Physical Electric Conductivity General and cellular metabolism. Vitamins General pharmacology Light Medical sciences micellar solubilization micelle(s) Micelles Oxidants - chemistry Pharmaceutical Preparations - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Picrates - chemistry Refractometry Scattering, Radiation Solubility Solvents Spectrophotometry, Ultraviolet Surface Tension Viscosity vitamin C
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