Long‐acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model

The therapeutic effects of the Sonic hedgehog (Shh) have been difficult to evaluate because of its relatively short serum half‐life. To address this issue polyethylene glycol modification (PEGylation) was investigated as an approach to improve systemic exposure. Shh was PEGylated by a targeted appro...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2002-02, Vol.91 (2), p.371-387
Hauptverfasser:	Pepinsky, R.Blake, Shapiro, Renee I., Wang, Shaoshan, Chakraborty, Abhijit, Gill, Alan, Lepage, Doreen J., Wen, Dingyi, Rayhorn, Paul, Horan, Gerald S.B., Taylor, Frederick R., Garber, Ellen A., Galdes, Alphonse, Engber, Thomas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line - drug effects Chemistry, Pharmaceutical Disease Models, Animal Dose-Response Relationship, Drug Excipients - pharmacokinetics Excipients - therapeutic use General pharmacology Hedgehog Proteins Humans Lac Operon - genetics Male Medical sciences Mice Mice, Transgenic Mutagenesis, Site-Directed - genetics Mutation - genetics Nerve Crush nerve injury model PEGylation Pharmaceutical technology. Pharmaceutical industry pharmacokinetics Pharmacology. Drug treatments polyethylene glycol-modified Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - therapeutic use Rats Rats, Sprague-Dawley Sciatic Neuropathy - blood Sciatic Neuropathy - drug therapy Sciatic Neuropathy - genetics Sonic hedgehog Trans-Activators - blood Trans-Activators - pharmacokinetics Trans-Activators - therapeutic use
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