Novel protein therapeutic joint retention strategy based on collagen‐binding Avimers

ABSTRACT Designing drugs to treat diseases associated with articular joints, particularly those targeting chondrocytes, is challenging due to unique local environmental constraints including the avascular nature of cartilage, the absence of a closed joint compartment, and a highly cross‐linked extra...

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Veröffentlicht in:	Journal of orthopaedic research 2018-04, Vol.36 (4), p.1238-1247
Hauptverfasser:	Hulme, Joanne T., D'Souza, Warren N., McBride, Helen J., Yoon, Bo‐Rin Park, Willee, Angela M., Duguay, Amy, Thomas, Melissa, Fan, Bin, Dayao, Maria Rosalyn, Rottman, James B., Merriam, Kim, Xie, Jiansong, Smith, Richard, Alba, Benjamin M., Case, Ryan B., Dang, Khue, Montalvan, Anielka, Grinberg, Natalia, Sun, Hong, Black, Roy A., Gabel, Christopher A., Sims, John E., Moore, Kevin, Bakker, Alice, Li, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals avimer cartilage Collagen Type II - metabolism Drug Delivery Systems - methods Female Humans IL‐1Ra Injections, Intra-Articular Joint Diseases - drug therapy joint‐retention Male osteoarthritis Protein Domains Protein Engineering Proteins - administration & dosage Rats, Inbred Lew Rats, Sprague-Dawley
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