Magnetic resonance imaging of osteoarthritis: Correlation with gross pathology using an experimental model
Conventional radiography has several limitations in the study of osteoarthritis (OA): changes occur late, they are restricted to bone, and they do not correlate well with the patient's symptoms. Magnetic resonance imaging (MRI) can visualize with great detail the soft tissue changes in and arou...
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| Veröffentlicht in: | Journal of orthopaedic research 1987, Vol.5 (2), p.164-172 |
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| container_title | Journal of orthopaedic research |
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| creator | Sabiston, C. Paul Adams, Mark E. Li, David K. B. |
| description | Conventional radiography has several limitations in the study of osteoarthritis (OA): changes occur late, they are restricted to bone, and they do not correlate well with the patient's symptoms. Magnetic resonance imaging (MRI) can visualize with great detail the soft tissue changes in and around joints. We have obtained MR images of knees using an experimental model of OA in order to study the early changes of OA, to correlate the images with the gross patnology, and to compare MR images with radiographs. The changes on MRI correlated with the gross pathological changes as assessed by Kendall's rank correlation test as follows: meniscal changes, τ = 0.58 (p < 0.01); osteophytes, τ = 0.59 (p < 0.05); capsular fibrosis, τ = 0.55 (p < 0.05); and overall, τ = 0.68 (p < 0.001). Abnormalities were evident on MRI as early as 4 weeks after the onset of the disease, which is 8 weeks before they appear on radiographs. Thus, MRI can show changes in OA earlier than radiography can, and the images correlate with the gross pathology. |
| doi_str_mv | 10.1002/jor.1100050203 |
| format | Article |
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Paul ; Adams, Mark E. ; Li, David K. B.</creator><creatorcontrib>Sabiston, C. Paul ; Adams, Mark E. ; Li, David K. B.</creatorcontrib><description>Conventional radiography has several limitations in the study of osteoarthritis (OA): changes occur late, they are restricted to bone, and they do not correlate well with the patient's symptoms. Magnetic resonance imaging (MRI) can visualize with great detail the soft tissue changes in and around joints. We have obtained MR images of knees using an experimental model of OA in order to study the early changes of OA, to correlate the images with the gross patnology, and to compare MR images with radiographs. The changes on MRI correlated with the gross pathological changes as assessed by Kendall's rank correlation test as follows: meniscal changes, τ = 0.58 (p < 0.01); osteophytes, τ = 0.59 (p < 0.05); capsular fibrosis, τ = 0.55 (p < 0.05); and overall, τ = 0.68 (p < 0.001). Abnormalities were evident on MRI as early as 4 weeks after the onset of the disease, which is 8 weeks before they appear on radiographs. Thus, MRI can show changes in OA earlier than radiography can, and the images correlate with the gross pathology.</description><identifier>ISSN: 0736-0266</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1002/jor.1100050203</identifier><identifier>PMID: 3572587</identifier><identifier>CODEN: JOREDR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Disease Models, Animal ; Diseases of the osteoarticular system ; Dogs ; Experimental osteoarthritis ; Fibrosis - pathology ; Hindlimb - pathology ; Joints - pathology ; Knee ; Magnetic resonance imaging ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; MRI ; Osteoarthritis ; Osteoarthritis - diagnosis ; Osteoarthritis - diagnostic imaging ; Osteoarthritis - pathology ; Radiography ; Synovial Fluid - pathology ; Time Factors</subject><ispartof>Journal of orthopaedic research, 1987, Vol.5 (2), p.164-172</ispartof><rights>Copyright © 1987 Orthopaedic Research Society</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3763-33155e7f15a8e6e5a55179ed952310347f45d5c15bcb5d1f60ab2500f17d30983</citedby><cites>FETCH-LOGICAL-c3763-33155e7f15a8e6e5a55179ed952310347f45d5c15bcb5d1f60ab2500f17d30983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjor.1100050203$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjor.1100050203$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8266162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3572587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sabiston, C. Paul</creatorcontrib><creatorcontrib>Adams, Mark E.</creatorcontrib><creatorcontrib>Li, David K. B.</creatorcontrib><title>Magnetic resonance imaging of osteoarthritis: Correlation with gross pathology using an experimental model</title><title>Journal of orthopaedic research</title><addtitle>J. Orthop. Res</addtitle><description>Conventional radiography has several limitations in the study of osteoarthritis (OA): changes occur late, they are restricted to bone, and they do not correlate well with the patient's symptoms. Magnetic resonance imaging (MRI) can visualize with great detail the soft tissue changes in and around joints. We have obtained MR images of knees using an experimental model of OA in order to study the early changes of OA, to correlate the images with the gross patnology, and to compare MR images with radiographs. The changes on MRI correlated with the gross pathological changes as assessed by Kendall's rank correlation test as follows: meniscal changes, τ = 0.58 (p < 0.01); osteophytes, τ = 0.59 (p < 0.05); capsular fibrosis, τ = 0.55 (p < 0.05); and overall, τ = 0.68 (p < 0.001). Abnormalities were evident on MRI as early as 4 weeks after the onset of the disease, which is 8 weeks before they appear on radiographs. Thus, MRI can show changes in OA earlier than radiography can, and the images correlate with the gross pathology.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Diseases of the osteoarticular system</subject><subject>Dogs</subject><subject>Experimental osteoarthritis</subject><subject>Fibrosis - pathology</subject><subject>Hindlimb - pathology</subject><subject>Joints - pathology</subject><subject>Knee</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MRI</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - diagnosis</subject><subject>Osteoarthritis - diagnostic imaging</subject><subject>Osteoarthritis - pathology</subject><subject>Radiography</subject><subject>Synovial Fluid - pathology</subject><subject>Time Factors</subject><issn>0736-0266</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEURoMoWh9bd0IWbqfm0TuZutOiVfGBoihuQjpzZ5o6nZRkRPvvTWmpuHKVwD1f8t1DyCFnXc6YOJk43-XxxoAJJjdIhwP0EhDqbZN0mJJpwkSa7pDdECaRUlxk22RbghKQqQ6Z3Jmqwdbm1GNwjWlypHZqKttU1JXUhRad8e3Y29aGUzpw3mNtWusa-mXbMa28C4HOTDt2tavm9DMskqah-D1Db6fYtKamU1dgvU-2SlMHPFide-Tl8uJ5cJXcPgyvB2e3SS5VKhMp4waoSg4mwxTBAHDVx6IPQnIme6rsQQE5h1E-goKXKTMjAYyVXBWS9TO5R7rLd_NFN4-lnsUixs81Z3rhTEdn-tdZDBwtA7PP0RSLNb6SFOfHq7kJualLHy3ZsMay6JenImL9JfZla5z_86m-eXj6UyFZZm0U_r3OGv-hUyUV6Nf7oX5nqvf4fj7Ub_IHZbaVfA</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Sabiston, C. Paul</creator><creator>Adams, Mark E.</creator><creator>Li, David K. B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1987</creationdate><title>Magnetic resonance imaging of osteoarthritis: Correlation with gross pathology using an experimental model</title><author>Sabiston, C. Paul ; Adams, Mark E. ; Li, David K. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3763-33155e7f15a8e6e5a55179ed952310347f45d5c15bcb5d1f60ab2500f17d30983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Diseases of the osteoarticular system</topic><topic>Dogs</topic><topic>Experimental osteoarthritis</topic><topic>Fibrosis - pathology</topic><topic>Hindlimb - pathology</topic><topic>Joints - pathology</topic><topic>Knee</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MRI</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - diagnosis</topic><topic>Osteoarthritis - diagnostic imaging</topic><topic>Osteoarthritis - pathology</topic><topic>Radiography</topic><topic>Synovial Fluid - pathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabiston, C. Paul</creatorcontrib><creatorcontrib>Adams, Mark E.</creatorcontrib><creatorcontrib>Li, David K. B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of orthopaedic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabiston, C. Paul</au><au>Adams, Mark E.</au><au>Li, David K. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging of osteoarthritis: Correlation with gross pathology using an experimental model</atitle><jtitle>Journal of orthopaedic research</jtitle><addtitle>J. Orthop. Res</addtitle><date>1987</date><risdate>1987</risdate><volume>5</volume><issue>2</issue><spage>164</spage><epage>172</epage><pages>164-172</pages><issn>0736-0266</issn><eissn>1554-527X</eissn><coden>JOREDR</coden><abstract>Conventional radiography has several limitations in the study of osteoarthritis (OA): changes occur late, they are restricted to bone, and they do not correlate well with the patient's symptoms. Magnetic resonance imaging (MRI) can visualize with great detail the soft tissue changes in and around joints. We have obtained MR images of knees using an experimental model of OA in order to study the early changes of OA, to correlate the images with the gross patnology, and to compare MR images with radiographs. The changes on MRI correlated with the gross pathological changes as assessed by Kendall's rank correlation test as follows: meniscal changes, τ = 0.58 (p < 0.01); osteophytes, τ = 0.59 (p < 0.05); capsular fibrosis, τ = 0.55 (p < 0.05); and overall, τ = 0.68 (p < 0.001). Abnormalities were evident on MRI as early as 4 weeks after the onset of the disease, which is 8 weeks before they appear on radiographs. Thus, MRI can show changes in OA earlier than radiography can, and the images correlate with the gross pathology.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3572587</pmid><doi>10.1002/jor.1100050203</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of orthopaedic research, 1987, Vol.5 (2), p.164-172 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Disease Models, Animal Diseases of the osteoarticular system Dogs Experimental osteoarthritis Fibrosis - pathology Hindlimb - pathology Joints - pathology Knee Magnetic resonance imaging Magnetic Resonance Spectroscopy Male Medical sciences MRI Osteoarthritis Osteoarthritis - diagnosis Osteoarthritis - diagnostic imaging Osteoarthritis - pathology Radiography Synovial Fluid - pathology Time Factors |
| title | Magnetic resonance imaging of osteoarthritis: Correlation with gross pathology using an experimental model |
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