Orphan receptor COUP-TF I antagonizes retinoic acid-induced neuronal differentiation
Chicken ovalbumin upstream promoter‐transcription factors (COUP‐TF) are expressed in the developing nervous system and interact with nuclear hormone receptors to regulate expression of different genes. The role of COUP‐TF orphan receptors in neurogenesis is virtually unknown. To study the possible f...
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| Veröffentlicht in: | Journal of neuroscience research 1995-05, Vol.41 (1), p.39-48 |
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| creator | Neuman, K. Soosaar, A. Nornes, H. O. Neuman, Toomas |
| description | Chicken ovalbumin upstream promoter‐transcription factors (COUP‐TF) are expressed in the developing nervous system and interact with nuclear hormone receptors to regulate expression of different genes. The role of COUP‐TF orphan receptors in neurogenesis is virtually unknown. To study the possible function of COUP‐TF I during neuronal differentiation, we generated COUP‐TF I overexpressing teratocarcinoma PCC7 cell lines and analyzed retinoic acid (RA)‐induced neuronal differentiation of these cells. COUP‐TF I overexpression results in the blockade of morphological differentiation after induction to differentiate. COUP‐TF I represses expression of micro‐tubule‐associated protein 2 (MAP2) gene and delays induction of growth‐associated protein 43 (GAP43) gene expression. In contrast, expression of the neurofilament light subunit (NF‐L) gene is not affected by COUP‐TF I overexpression during neuronal differentiation. Also, cells overexpressing COUP‐TF I do not stop proliferating after RA and dBcAMP treatment and possess suppressed transcriptional activation from different RA response elements. These results suggest that COUP‐TF I plays an important role in regulating RA‐induced neuronal differentiation.© 1995 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jnr.490410106 |
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O. ; Neuman, Toomas</creator><creatorcontrib>Neuman, K. ; Soosaar, A. ; Nornes, H. O. ; Neuman, Toomas</creatorcontrib><description>Chicken ovalbumin upstream promoter‐transcription factors (COUP‐TF) are expressed in the developing nervous system and interact with nuclear hormone receptors to regulate expression of different genes. The role of COUP‐TF orphan receptors in neurogenesis is virtually unknown. To study the possible function of COUP‐TF I during neuronal differentiation, we generated COUP‐TF I overexpressing teratocarcinoma PCC7 cell lines and analyzed retinoic acid (RA)‐induced neuronal differentiation of these cells. COUP‐TF I overexpression results in the blockade of morphological differentiation after induction to differentiate. COUP‐TF I represses expression of micro‐tubule‐associated protein 2 (MAP2) gene and delays induction of growth‐associated protein 43 (GAP43) gene expression. In contrast, expression of the neurofilament light subunit (NF‐L) gene is not affected by COUP‐TF I overexpression during neuronal differentiation. Also, cells overexpressing COUP‐TF I do not stop proliferating after RA and dBcAMP treatment and possess suppressed transcriptional activation from different RA response elements. These results suggest that COUP‐TF I plays an important role in regulating RA‐induced neuronal differentiation.© 1995 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.490410106</identifier><identifier>PMID: 7674376</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Base Sequence ; Biomarkers ; Bucladesine - pharmacology ; Cell Cycle - drug effects ; Cell Cycle - genetics ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; COUP Transcription Factor I ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - pharmacology ; Enhancer Elements, Genetic - genetics ; GAP-43 Protein ; GAP43 ; gene expression ; Gene Expression - physiology ; MAP2 ; Membrane Glycoproteins - genetics ; Mice ; Microtubule-Associated Proteins - genetics ; Molecular Sequence Data ; Nerve Tissue Proteins - genetics ; neurofilament ; Neurofilament Proteins - genetics ; nuclear hormone receptors ; Receptors, Glucocorticoid - physiology ; teratocarcinoma ; Teratocarcinoma - pathology ; Teratocarcinoma - physiopathology ; Transcription Factors - genetics ; Transcription Factors - pharmacology ; Tretinoin - pharmacology ; Tumor Cells, Cultured - cytology</subject><ispartof>Journal of neuroscience research, 1995-05, Vol.41 (1), p.39-48</ispartof><rights>Copyright © 1995 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4406-ef4f86341cde7ea1ac35e91e09018f1be2227247c280a1faeca5cc58cbef51123</citedby><cites>FETCH-LOGICAL-c4406-ef4f86341cde7ea1ac35e91e09018f1be2227247c280a1faeca5cc58cbef51123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.490410106$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.490410106$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7674376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neuman, K.</creatorcontrib><creatorcontrib>Soosaar, A.</creatorcontrib><creatorcontrib>Nornes, H. O.</creatorcontrib><creatorcontrib>Neuman, Toomas</creatorcontrib><title>Orphan receptor COUP-TF I antagonizes retinoic acid-induced neuronal differentiation</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>Chicken ovalbumin upstream promoter‐transcription factors (COUP‐TF) are expressed in the developing nervous system and interact with nuclear hormone receptors to regulate expression of different genes. The role of COUP‐TF orphan receptors in neurogenesis is virtually unknown. To study the possible function of COUP‐TF I during neuronal differentiation, we generated COUP‐TF I overexpressing teratocarcinoma PCC7 cell lines and analyzed retinoic acid (RA)‐induced neuronal differentiation of these cells. COUP‐TF I overexpression results in the blockade of morphological differentiation after induction to differentiate. COUP‐TF I represses expression of micro‐tubule‐associated protein 2 (MAP2) gene and delays induction of growth‐associated protein 43 (GAP43) gene expression. In contrast, expression of the neurofilament light subunit (NF‐L) gene is not affected by COUP‐TF I overexpression during neuronal differentiation. Also, cells overexpressing COUP‐TF I do not stop proliferating after RA and dBcAMP treatment and possess suppressed transcriptional activation from different RA response elements. These results suggest that COUP‐TF I plays an important role in regulating RA‐induced neuronal differentiation.© 1995 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biomarkers</subject><subject>Bucladesine - pharmacology</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Cycle - genetics</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>COUP Transcription Factor I</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - pharmacology</subject><subject>Enhancer Elements, Genetic - genetics</subject><subject>GAP-43 Protein</subject><subject>GAP43</subject><subject>gene expression</subject><subject>Gene Expression - physiology</subject><subject>MAP2</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Mice</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Molecular Sequence Data</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>neurofilament</subject><subject>Neurofilament Proteins - genetics</subject><subject>nuclear hormone receptors</subject><subject>Receptors, Glucocorticoid - physiology</subject><subject>teratocarcinoma</subject><subject>Teratocarcinoma - pathology</subject><subject>Teratocarcinoma - physiopathology</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - pharmacology</subject><subject>Tretinoin - pharmacology</subject><subject>Tumor Cells, Cultured - cytology</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwkAURSdGg4guXZr0DxTfTKeddmmIfBgChhRdTobpGx2EaTMtUfz11kCIK1dvce69eTmE3FLoUwB2v3a-zzPgFCgkZ6RLIRMhj7k4J12IEgg5UHZJrup6DQBZFkcd0hGJ4JFIuiSf--pducCjxqopfTCYL5_DfBhMAuUa9VY6-411ixvrSqsDpW0RWlfsNBaBw50vndoEhTUGPbrGqsaW7ppcGLWp8eZ4e2Q5fMwH43A6H00GD9NQcw5JiIabNIk41QUKVFTpKMaMImRAU0NXyBgTjAvNUlDUKNQq1jpO9QpNTCmLeiQ87Gpf1rVHIytvt8rvJQX5K0e2cuRJTpu_O-Sr3WqLxSl9tNFyceCfdoP7_8fk02zxd_n4ia0b_Do1lf-QiYhELF9nI8mAjWmSL-RL9AMYs3_6</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>Neuman, K.</creator><creator>Soosaar, A.</creator><creator>Nornes, H. O.</creator><creator>Neuman, Toomas</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19950501</creationdate><title>Orphan receptor COUP-TF I antagonizes retinoic acid-induced neuronal differentiation</title><author>Neuman, K. ; Soosaar, A. ; Nornes, H. O. ; Neuman, Toomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4406-ef4f86341cde7ea1ac35e91e09018f1be2227247c280a1faeca5cc58cbef51123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biomarkers</topic><topic>Bucladesine - pharmacology</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Cycle - genetics</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - physiology</topic><topic>COUP Transcription Factor I</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - pharmacology</topic><topic>Enhancer Elements, Genetic - genetics</topic><topic>GAP-43 Protein</topic><topic>GAP43</topic><topic>gene expression</topic><topic>Gene Expression - physiology</topic><topic>MAP2</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Mice</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Molecular Sequence Data</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>neurofilament</topic><topic>Neurofilament Proteins - genetics</topic><topic>nuclear hormone receptors</topic><topic>Receptors, Glucocorticoid - physiology</topic><topic>teratocarcinoma</topic><topic>Teratocarcinoma - pathology</topic><topic>Teratocarcinoma - physiopathology</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - pharmacology</topic><topic>Tretinoin - pharmacology</topic><topic>Tumor Cells, Cultured - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neuman, K.</creatorcontrib><creatorcontrib>Soosaar, A.</creatorcontrib><creatorcontrib>Nornes, H. O.</creatorcontrib><creatorcontrib>Neuman, Toomas</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neuman, K.</au><au>Soosaar, A.</au><au>Nornes, H. O.</au><au>Neuman, Toomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orphan receptor COUP-TF I antagonizes retinoic acid-induced neuronal differentiation</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>41</volume><issue>1</issue><spage>39</spage><epage>48</epage><pages>39-48</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>Chicken ovalbumin upstream promoter‐transcription factors (COUP‐TF) are expressed in the developing nervous system and interact with nuclear hormone receptors to regulate expression of different genes. The role of COUP‐TF orphan receptors in neurogenesis is virtually unknown. To study the possible function of COUP‐TF I during neuronal differentiation, we generated COUP‐TF I overexpressing teratocarcinoma PCC7 cell lines and analyzed retinoic acid (RA)‐induced neuronal differentiation of these cells. COUP‐TF I overexpression results in the blockade of morphological differentiation after induction to differentiate. COUP‐TF I represses expression of micro‐tubule‐associated protein 2 (MAP2) gene and delays induction of growth‐associated protein 43 (GAP43) gene expression. In contrast, expression of the neurofilament light subunit (NF‐L) gene is not affected by COUP‐TF I overexpression during neuronal differentiation. Also, cells overexpressing COUP‐TF I do not stop proliferating after RA and dBcAMP treatment and possess suppressed transcriptional activation from different RA response elements. These results suggest that COUP‐TF I plays an important role in regulating RA‐induced neuronal differentiation.© 1995 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>7674376</pmid><doi>10.1002/jnr.490410106</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Base Sequence Biomarkers Bucladesine - pharmacology Cell Cycle - drug effects Cell Cycle - genetics Cell Differentiation - drug effects Cell Differentiation - physiology COUP Transcription Factor I DNA-Binding Proteins - genetics DNA-Binding Proteins - pharmacology Enhancer Elements, Genetic - genetics GAP-43 Protein GAP43 gene expression Gene Expression - physiology MAP2 Membrane Glycoproteins - genetics Mice Microtubule-Associated Proteins - genetics Molecular Sequence Data Nerve Tissue Proteins - genetics neurofilament Neurofilament Proteins - genetics nuclear hormone receptors Receptors, Glucocorticoid - physiology teratocarcinoma Teratocarcinoma - pathology Teratocarcinoma - physiopathology Transcription Factors - genetics Transcription Factors - pharmacology Tretinoin - pharmacology Tumor Cells, Cultured - cytology |
| title | Orphan receptor COUP-TF I antagonizes retinoic acid-induced neuronal differentiation |
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