Aspartate-70 to glycine substitution confers resistance to naturally occurring and synthetic anionic-site ligands on inovo produced human butyrylcholinesterase

The “atypical” allelic variant of human butyrylcholinesterase (BuChE) can be characterized by its failure to bind the local anesthetic dibucaine, the muscle relaxant succinylcholine, and the naturally occurring steroidal alkaloid solanidine, all assumed to bind to the charged anionic site component...

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Veröffentlicht in:	Journal of neuroscience research 1990-12, Vol.27 (4), p.452-460
Hauptverfasser:	Neville, L. F., Gnatt, A., Loewenstein, Y., Soreq, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	in vivo mutagenesis selection advantage serum cholinesterase structure-function relationships transcription vectors
Online-Zugang:	Volltext
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