Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme

The longer and neurotoxic species of amyloid‐β protein (Aβ), Aβ42 and Aβ43, contribute to Aβ accumulation in Alzheimer's disease (AD) pathogenesis and are considered to be the primary cause of the disease. In contrast, the predominant secreted form of Aβ, Aβ40, inhibits amyloid deposition and m...

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Veröffentlicht in:	Journal of neuroscience research 2014-09, Vol.92 (9), p.1178-1186
Hauptverfasser:	Liu, Shuyu, Liu, Junjun, Miura, Yukie, Tanabe, Chiaki, Maeda, Tomoji, Terayama, Yasuo, Turner, Anthony J., Zou, Kun, Komano, Hiroto
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - blood Alzheimer's disease Amyloid beta-Peptides - drug effects Amyloid beta-Peptides - metabolism amyloid-β protein angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Brain - drug effects Brain - metabolism Enzyme-Linked Immunosorbent Assay Humans Mice Mice, Inbred C57BL Microscopy, Confocal Peptide Fragments - drug effects Peptide Fragments - metabolism Peptides - pharmacology Peptidyl-Dipeptidase A - metabolism Peptidyl-Dipeptidase A - pharmacology Serum - drug effects Serum - metabolism
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