Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia

Microglia play a variety of significant roles in the central nervous system (CNS), and in one of those roles they undergo morphological change in response to neural injury and migrate to the injured region. We previously reported that ATP/ADP promotes microglial chemotaxis via the Gi/o‐coupled P2Y12...

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Veröffentlicht in:	Journal of neuroscience research 2008-05, Vol.86 (7), p.1511-1519
Hauptverfasser:	Irino, Yasuhiro, Nakamura, Yasuko, Inoue, Kazuhide, Kohsaka, Shinichi, Ohsawa, Keiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - pharmacology Adenosine Triphosphate - pharmacology ADP Animals Animals, Newborn calcium Calcium - metabolism Cells, Cultured Cerebral Cortex - cytology Chemotaxis - drug effects Chemotaxis - physiology Drug Interactions Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Membrane Proteins - physiology Microglia - drug effects Microglia - physiology phosphatidylinositol 3-kinase phospholipase C Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Receptors, Purinergic P2 - physiology Signal Transduction - drug effects Signal Transduction - physiology Type C Phospholipases - metabolism
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