The janus faces of botulinum neurotoxin: Sensational medicine and deadly biological weapon

The botulinum neurotoxins are the most dangerous toxins known (BoNTs serotypes A–G) and induce profound flaccid neuromuscular paralysis by blocking nerve–muscle communication. Poisoned motoneurons react by emitting a sprouting network known to establish novel functional synapses with the abutting mu...

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Veröffentlicht in:	Journal of neuroscience research 2007-05, Vol.85 (6), p.1149-1158
Hauptverfasser:	Osborne, Shona L., Latham, Catherine F., Wen, Peter J., Cavaignac, Sonia, Fanning, Jonathon, Foran, Patrick G., Meunier, Frederic A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals botulinum neurotoxins Botulinum Toxins - chemistry Botulinum Toxins - therapeutic use Botulinum Toxins - toxicity Chemical Warfare Humans Models, Biological Motor Neurons - drug effects neuromuscular junc-tion Neuromuscular Junction - drug effects neuronal plasticity Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - pathology Neurotoxicity Syndromes - prevention & control Neurotoxins - chemistry Neurotoxins - therapeutic use Neurotoxins - toxicity paralysis protease inhibitor and biological weapon SNARE synaptic transmission
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