The janus faces of botulinum neurotoxin: Sensational medicine and deadly biological weapon
The botulinum neurotoxins are the most dangerous toxins known (BoNTs serotypes A–G) and induce profound flaccid neuromuscular paralysis by blocking nerve–muscle communication. Poisoned motoneurons react by emitting a sprouting network known to establish novel functional synapses with the abutting mu...
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| Veröffentlicht in: | Journal of neuroscience research 2007-05, Vol.85 (6), p.1149-1158 |
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| container_title | Journal of neuroscience research |
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| creator | Osborne, Shona L. Latham, Catherine F. Wen, Peter J. Cavaignac, Sonia Fanning, Jonathon Foran, Patrick G. Meunier, Frederic A. |
| description | The botulinum neurotoxins are the most dangerous toxins known (BoNTs serotypes A–G) and induce profound flaccid neuromuscular paralysis by blocking nerve–muscle communication. Poisoned motoneurons react by emitting a sprouting network known to establish novel functional synapses with the abutting muscle fiber. Understanding how our motoneurons are capable of bypassing such transmission blockade, thereby overcoming paralysis, by an astonishing display of plasticity is one of the research goals that have numerous therapeutic ramifications. This Mini‐Review aims at giving a brief update on the recent discoveries regarding the molecular mechanism of botulinum toxins intoxication. Curing botulism still is a challenge once the toxin has found his way inside motoneurons. In view of the potential use of botulinum toxins as biological weapon, more research is needed to find efficient ways of curing this disease. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jnr.21171 |
| format | Article |
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Poisoned motoneurons react by emitting a sprouting network known to establish novel functional synapses with the abutting muscle fiber. Understanding how our motoneurons are capable of bypassing such transmission blockade, thereby overcoming paralysis, by an astonishing display of plasticity is one of the research goals that have numerous therapeutic ramifications. This Mini‐Review aims at giving a brief update on the recent discoveries regarding the molecular mechanism of botulinum toxins intoxication. Curing botulism still is a challenge once the toxin has found his way inside motoneurons. In view of the potential use of botulinum toxins as biological weapon, more research is needed to find efficient ways of curing this disease. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.21171</identifier><identifier>PMID: 17387703</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; botulinum neurotoxins ; Botulinum Toxins - chemistry ; Botulinum Toxins - therapeutic use ; Botulinum Toxins - toxicity ; Chemical Warfare ; Humans ; Models, Biological ; Motor Neurons - drug effects ; neuromuscular junc-tion ; Neuromuscular Junction - drug effects ; neuronal plasticity ; Neurotoxicity Syndromes - etiology ; Neurotoxicity Syndromes - pathology ; Neurotoxicity Syndromes - prevention & control ; Neurotoxins - chemistry ; Neurotoxins - therapeutic use ; Neurotoxins - toxicity ; paralysis ; protease inhibitor and biological weapon ; SNARE ; synaptic transmission</subject><ispartof>Journal of neuroscience research, 2007-05, Vol.85 (6), p.1149-1158</ispartof><rights>Copyright © 2007 Wiley‐Liss, Inc.</rights><rights>(c) 2007 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4271-b64d7ca64320cbba0aa71ca4769a0e1f09b0434072cc2ff502eef564b81ed7f63</citedby><cites>FETCH-LOGICAL-c4271-b64d7ca64320cbba0aa71ca4769a0e1f09b0434072cc2ff502eef564b81ed7f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.21171$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.21171$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17387703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osborne, Shona L.</creatorcontrib><creatorcontrib>Latham, Catherine F.</creatorcontrib><creatorcontrib>Wen, Peter J.</creatorcontrib><creatorcontrib>Cavaignac, Sonia</creatorcontrib><creatorcontrib>Fanning, Jonathon</creatorcontrib><creatorcontrib>Foran, Patrick G.</creatorcontrib><creatorcontrib>Meunier, Frederic A.</creatorcontrib><title>The janus faces of botulinum neurotoxin: Sensational medicine and deadly biological weapon</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>The botulinum neurotoxins are the most dangerous toxins known (BoNTs serotypes A–G) and induce profound flaccid neuromuscular paralysis by blocking nerve–muscle communication. Poisoned motoneurons react by emitting a sprouting network known to establish novel functional synapses with the abutting muscle fiber. Understanding how our motoneurons are capable of bypassing such transmission blockade, thereby overcoming paralysis, by an astonishing display of plasticity is one of the research goals that have numerous therapeutic ramifications. This Mini‐Review aims at giving a brief update on the recent discoveries regarding the molecular mechanism of botulinum toxins intoxication. Curing botulism still is a challenge once the toxin has found his way inside motoneurons. In view of the potential use of botulinum toxins as biological weapon, more research is needed to find efficient ways of curing this disease. © 2007 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>botulinum neurotoxins</subject><subject>Botulinum Toxins - chemistry</subject><subject>Botulinum Toxins - therapeutic use</subject><subject>Botulinum Toxins - toxicity</subject><subject>Chemical Warfare</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Motor Neurons - drug effects</subject><subject>neuromuscular junc-tion</subject><subject>Neuromuscular Junction - drug effects</subject><subject>neuronal plasticity</subject><subject>Neurotoxicity Syndromes - etiology</subject><subject>Neurotoxicity Syndromes - pathology</subject><subject>Neurotoxicity Syndromes - prevention & control</subject><subject>Neurotoxins - chemistry</subject><subject>Neurotoxins - therapeutic use</subject><subject>Neurotoxins - toxicity</subject><subject>paralysis</subject><subject>protease inhibitor and biological weapon</subject><subject>SNARE</subject><subject>synaptic transmission</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EoqUw8AeQV4aU60fihg0qnkIFQRGIxXIcG1xSu4oTQf89gfKYmO5wvnOk-yG0S2BIAOjBzNdDSogga6hPIBcJT7lYR31gGSQcCO2hrRhnAJDnKdtEPSLYSAhgffQ0fTF4pnwbsVXaRBwsLkLTVs63c-xNW4cmvDt_iO-Mj6pxwasKz03ptPMGK1_i0qiyWuLChSo8O93Fb0Ytgt9GG1ZV0ex83wG6Pz2Zjs-Tq-uzi_HRVaI5FSQpMl4KrTLOKOiiUKCUIFpxkeUKDLGQF8AZB0G1ptamQI2xacaLETGlsBkboP3Vrq5DjLWxclG7uaqXkoD89CM7P_LLT8furdhFW3RP_JHfQjrgYAW8ucos_1-Sl5Pbn8lk1XCxMe-_DVW_ykwwkcqHyZlkj48jcnNzLHP2AdX9f6s</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Osborne, Shona L.</creator><creator>Latham, Catherine F.</creator><creator>Wen, Peter J.</creator><creator>Cavaignac, Sonia</creator><creator>Fanning, Jonathon</creator><creator>Foran, Patrick G.</creator><creator>Meunier, Frederic A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20070501</creationdate><title>The janus faces of botulinum neurotoxin: Sensational medicine and deadly biological weapon</title><author>Osborne, Shona L. ; Latham, Catherine F. ; Wen, Peter J. ; Cavaignac, Sonia ; Fanning, Jonathon ; Foran, Patrick G. ; Meunier, Frederic A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4271-b64d7ca64320cbba0aa71ca4769a0e1f09b0434072cc2ff502eef564b81ed7f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>botulinum neurotoxins</topic><topic>Botulinum Toxins - chemistry</topic><topic>Botulinum Toxins - therapeutic use</topic><topic>Botulinum Toxins - toxicity</topic><topic>Chemical Warfare</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Motor Neurons - drug effects</topic><topic>neuromuscular junc-tion</topic><topic>Neuromuscular Junction - drug effects</topic><topic>neuronal plasticity</topic><topic>Neurotoxicity Syndromes - etiology</topic><topic>Neurotoxicity Syndromes - pathology</topic><topic>Neurotoxicity Syndromes - prevention & control</topic><topic>Neurotoxins - chemistry</topic><topic>Neurotoxins - therapeutic use</topic><topic>Neurotoxins - toxicity</topic><topic>paralysis</topic><topic>protease inhibitor and biological weapon</topic><topic>SNARE</topic><topic>synaptic transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osborne, Shona L.</creatorcontrib><creatorcontrib>Latham, Catherine F.</creatorcontrib><creatorcontrib>Wen, Peter J.</creatorcontrib><creatorcontrib>Cavaignac, Sonia</creatorcontrib><creatorcontrib>Fanning, Jonathon</creatorcontrib><creatorcontrib>Foran, Patrick G.</creatorcontrib><creatorcontrib>Meunier, Frederic A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osborne, Shona L.</au><au>Latham, Catherine F.</au><au>Wen, Peter J.</au><au>Cavaignac, Sonia</au><au>Fanning, Jonathon</au><au>Foran, Patrick G.</au><au>Meunier, Frederic A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The janus faces of botulinum neurotoxin: Sensational medicine and deadly biological weapon</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. 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| ispartof | Journal of neuroscience research, 2007-05, Vol.85 (6), p.1149-1158 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals botulinum neurotoxins Botulinum Toxins - chemistry Botulinum Toxins - therapeutic use Botulinum Toxins - toxicity Chemical Warfare Humans Models, Biological Motor Neurons - drug effects neuromuscular junc-tion Neuromuscular Junction - drug effects neuronal plasticity Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - pathology Neurotoxicity Syndromes - prevention & control Neurotoxins - chemistry Neurotoxins - therapeutic use Neurotoxins - toxicity paralysis protease inhibitor and biological weapon SNARE synaptic transmission |
| title | The janus faces of botulinum neurotoxin: Sensational medicine and deadly biological weapon |
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