Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity

The cytokine interleukin‐1 (IL‐1) is an established and important mediator of diverse forms of neuronal injury in experimental animals. However, its mechanisms of action remain largely unknown. We have reported previously that IL‐1 markedly enhances excitotoxic injury induced in the rat by striatal...

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Veröffentlicht in:	Journal of neuroscience research 2006-02, Vol.83 (3), p.385-391
Hauptverfasser:	Patel, H.C., Ross, F.M., Heenan, L.E., Davies, R.E., Rothwell, N.J., Allan, S.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - toxicity Analysis of Variance Animals Anticonvulsants - therapeutic use Cell Count - methods cell death Cell Death - drug effects Corpus Striatum - drug effects Corpus Striatum - pathology Corpus Striatum - physiopathology cytokines Diazepam - administration & dosage Diazepam - therapeutic use Disease Models, Animal Drug Interactions Electroencephalography - methods epilepsy excitotoxicity Immunohistochemistry - methods inflammation Interleukin-1 - toxicity Male Nerve Degeneration - drug therapy Nerve Degeneration - etiology Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Seizures - complications Seizures - drug therapy Time Factors
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