c-Kit receptor expression in normal human Schwann cells and Schwann cell lines derived from neurofibromatosis type 1 tumors
The growth factor receptor c‐Kit has several well‐characterized functions during the development of numerous cell types, including red blood cells, mast cells, and melanocytes. Its role in Schwann cells has been described in transformed cells derived from malignant peripheral nerve sheath tumors fro...
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| Veröffentlicht in: | Journal of neuroscience research 2005-11, Vol.82 (4), p.465-471 |
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| description | The growth factor receptor c‐Kit has several well‐characterized functions during the development of numerous cell types, including red blood cells, mast cells, and melanocytes. Its role in Schwann cells has been described in transformed cells derived from malignant peripheral nerve sheath tumors from patients with neurofibromatosis type 1 (NF1 MPNST; Badache et al. [1998] Oncogene 17:795–800). However, c‐Kit functions have not been investigated in normal Schwann cells. We report here that neonatal rat Schwann cells express low c‐Kit levels, whereas expression levels for c‐Kit are high for Schwann cells derived from MPNST of NF1 patients. In addition, c‐Kit expression is not detectable in normal adult human Schwann cells. Although the c‐Kit ligand stem cell factor (SCF) induces the phosphorylation of protein kinase B (or Akt) and prevents apoptosis in Schwann cells, SCF has no effect on the proliferation or differentiation of Schwann cells. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jnr.20648 |
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Its role in Schwann cells has been described in transformed cells derived from malignant peripheral nerve sheath tumors from patients with neurofibromatosis type 1 (NF1 MPNST; Badache et al. [1998] Oncogene 17:795–800). However, c‐Kit functions have not been investigated in normal Schwann cells. We report here that neonatal rat Schwann cells express low c‐Kit levels, whereas expression levels for c‐Kit are high for Schwann cells derived from MPNST of NF1 patients. In addition, c‐Kit expression is not detectable in normal adult human Schwann cells. Although the c‐Kit ligand stem cell factor (SCF) induces the phosphorylation of protein kinase B (or Akt) and prevents apoptosis in Schwann cells, SCF has no effect on the proliferation or differentiation of Schwann cells. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.20648</identifier><identifier>PMID: 16235251</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Akt ; Analysis of Variance ; Animals ; Animals, Newborn ; apoptosis ; Apoptosis - drug effects ; Blotting, Northern ; Blotting, Western - methods ; Bromodeoxyuridine - metabolism ; c-Kit ; Cell Count - methods ; Cell Differentiation - drug effects ; Cell Proliferation - drug effects ; Cells, Cultured ; Chromones - pharmacology ; Dose-Response Relationship, Drug ; Drug Interactions ; Enzyme Inhibitors - pharmacology ; Gene Expression - drug effects ; Gene Expression - physiology ; Gene Expression Regulation, Neoplastic - drug effects ; Gene Expression Regulation, Neoplastic - physiology ; Humans ; In Situ Nick-End Labeling - methods ; Morpholines - pharmacology ; MPNST ; Neuregulin-1 - pharmacology ; Neurofibromatoses - metabolism ; Neurofibromatoses - pathology ; neurofibromatosis type 1 ; Neurofibromin 1 - metabolism ; Proto-Oncogene Proteins c-akt - metabolism ; Proto-Oncogene Proteins c-kit - genetics ; Proto-Oncogene Proteins c-kit - metabolism ; Proto-Oncogene Proteins c-kit - pharmacology ; Rats ; Reverse Transcriptase Polymerase Chain Reaction - methods ; RNA, Messenger - biosynthesis ; Schwann cells ; Schwann Cells - drug effects ; Schwann Cells - metabolism ; Time Factors</subject><ispartof>Journal of neuroscience research, 2005-11, Vol.82 (4), p.465-471</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>Copyright 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3618-a93b69de6b4e2e301bb6ccd1371549b188647a53042454325419fd3d5fefd5d3</citedby><cites>FETCH-LOGICAL-c3618-a93b69de6b4e2e301bb6ccd1371549b188647a53042454325419fd3d5fefd5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.20648$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.20648$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16235251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dang, Ian</creatorcontrib><creatorcontrib>Nelson, Julie K.</creatorcontrib><creatorcontrib>DeVries, George H.</creatorcontrib><title>c-Kit receptor expression in normal human Schwann cells and Schwann cell lines derived from neurofibromatosis type 1 tumors</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>The growth factor receptor c‐Kit has several well‐characterized functions during the development of numerous cell types, including red blood cells, mast cells, and melanocytes. Its role in Schwann cells has been described in transformed cells derived from malignant peripheral nerve sheath tumors from patients with neurofibromatosis type 1 (NF1 MPNST; Badache et al. [1998] Oncogene 17:795–800). However, c‐Kit functions have not been investigated in normal Schwann cells. We report here that neonatal rat Schwann cells express low c‐Kit levels, whereas expression levels for c‐Kit are high for Schwann cells derived from MPNST of NF1 patients. In addition, c‐Kit expression is not detectable in normal adult human Schwann cells. Although the c‐Kit ligand stem cell factor (SCF) induces the phosphorylation of protein kinase B (or Akt) and prevents apoptosis in Schwann cells, SCF has no effect on the proliferation or differentiation of Schwann cells. © 2005 Wiley‐Liss, Inc.</description><subject>Akt</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Blotting, Northern</subject><subject>Blotting, Western - methods</subject><subject>Bromodeoxyuridine - metabolism</subject><subject>c-Kit</subject><subject>Cell Count - methods</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Chromones - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - physiology</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Humans</subject><subject>In Situ Nick-End Labeling - methods</subject><subject>Morpholines - pharmacology</subject><subject>MPNST</subject><subject>Neuregulin-1 - pharmacology</subject><subject>Neurofibromatoses - metabolism</subject><subject>Neurofibromatoses - pathology</subject><subject>neurofibromatosis type 1</subject><subject>Neurofibromin 1 - metabolism</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Proto-Oncogene Proteins c-kit - genetics</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Proto-Oncogene Proteins c-kit - pharmacology</subject><subject>Rats</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Schwann cells</subject><subject>Schwann Cells - drug effects</subject><subject>Schwann Cells - metabolism</subject><subject>Time Factors</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKxDAUhoMoOo4ufAHJ1kWd3NsuxfttBB1wGdLmFKNtWpKOOvjyVscLLlydw-H7fzgfQjuU7FNC2OTRh31GlMhW0IiSPE2EFOkqGhGuSCIIZRtoM8ZHQkieS76ONqhiXDJJR-itTC5djwOU0PVtwPDaBYjRtR47j30bGlPjh3ljPL4rH16M97iEuo7YePvngmvnIWILwT2DxVVoG-xhHtrKFcNu-ja6iPtFB5jift60IW6htcrUEba_5hjNTo5nh2fJ1c3p-eHBVVJyRbPE5LxQuQVVCGDACS0KVZaW8pRKkRc0y5RIjeREsOFvzqSgeWW5lRVUVlo-RnvL2jK0MQaodBdcY8JCU6I__OnBn_70N7C7S7abFw3YX_JL2ABMlsCLq2Hxf5O-mN5-VybLhIs9vP4kTHjSKuWp1PfTU32UXjOW8Zme8nfhZ4rN</recordid><startdate>20051115</startdate><enddate>20051115</enddate><creator>Dang, Ian</creator><creator>Nelson, Julie K.</creator><creator>DeVries, George H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20051115</creationdate><title>c-Kit receptor expression in normal human Schwann cells and Schwann cell lines derived from neurofibromatosis type 1 tumors</title><author>Dang, Ian ; Nelson, Julie K. ; DeVries, George H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3618-a93b69de6b4e2e301bb6ccd1371549b188647a53042454325419fd3d5fefd5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Akt</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Blotting, Northern</topic><topic>Blotting, Western - methods</topic><topic>Bromodeoxyuridine - metabolism</topic><topic>c-Kit</topic><topic>Cell Count - methods</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Chromones - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - physiology</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>Humans</topic><topic>In Situ Nick-End Labeling - methods</topic><topic>Morpholines - pharmacology</topic><topic>MPNST</topic><topic>Neuregulin-1 - pharmacology</topic><topic>Neurofibromatoses - metabolism</topic><topic>Neurofibromatoses - pathology</topic><topic>neurofibromatosis type 1</topic><topic>Neurofibromin 1 - metabolism</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Proto-Oncogene Proteins c-kit - genetics</topic><topic>Proto-Oncogene Proteins c-kit - metabolism</topic><topic>Proto-Oncogene Proteins c-kit - pharmacology</topic><topic>Rats</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Schwann cells</topic><topic>Schwann Cells - drug effects</topic><topic>Schwann Cells - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dang, Ian</creatorcontrib><creatorcontrib>Nelson, Julie K.</creatorcontrib><creatorcontrib>DeVries, George H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dang, Ian</au><au>Nelson, Julie K.</au><au>DeVries, George H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>c-Kit receptor expression in normal human Schwann cells and Schwann cell lines derived from neurofibromatosis type 1 tumors</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>2005-11-15</date><risdate>2005</risdate><volume>82</volume><issue>4</issue><spage>465</spage><epage>471</epage><pages>465-471</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>The growth factor receptor c‐Kit has several well‐characterized functions during the development of numerous cell types, including red blood cells, mast cells, and melanocytes. Its role in Schwann cells has been described in transformed cells derived from malignant peripheral nerve sheath tumors from patients with neurofibromatosis type 1 (NF1 MPNST; Badache et al. [1998] Oncogene 17:795–800). However, c‐Kit functions have not been investigated in normal Schwann cells. We report here that neonatal rat Schwann cells express low c‐Kit levels, whereas expression levels for c‐Kit are high for Schwann cells derived from MPNST of NF1 patients. In addition, c‐Kit expression is not detectable in normal adult human Schwann cells. Although the c‐Kit ligand stem cell factor (SCF) induces the phosphorylation of protein kinase B (or Akt) and prevents apoptosis in Schwann cells, SCF has no effect on the proliferation or differentiation of Schwann cells. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16235251</pmid><doi>10.1002/jnr.20648</doi><tpages>7</tpages></addata></record> |
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| subjects | Akt Analysis of Variance Animals Animals, Newborn apoptosis Apoptosis - drug effects Blotting, Northern Blotting, Western - methods Bromodeoxyuridine - metabolism c-Kit Cell Count - methods Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Chromones - pharmacology Dose-Response Relationship, Drug Drug Interactions Enzyme Inhibitors - pharmacology Gene Expression - drug effects Gene Expression - physiology Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - physiology Humans In Situ Nick-End Labeling - methods Morpholines - pharmacology MPNST Neuregulin-1 - pharmacology Neurofibromatoses - metabolism Neurofibromatoses - pathology neurofibromatosis type 1 Neurofibromin 1 - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Proto-Oncogene Proteins c-kit - pharmacology Rats Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Schwann cells Schwann Cells - drug effects Schwann Cells - metabolism Time Factors |
| title | c-Kit receptor expression in normal human Schwann cells and Schwann cell lines derived from neurofibromatosis type 1 tumors |
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