Prostaglandin-induced neurodegeneration is associated with increased levels of oxidative markers and reduced by a mixture of antioxidants

Prostaglandin E2 (PGE2), one product of inflammatory reactions, and PGA1, which is formed during PGE2 extraction, induce degeneration in adenosine 3′,5′‐cyclic monophosphate (cAMP)‐induced differentiated neuroblastoma (NB) cells in culture. The mechanisms of action of PGE2 on neurodegeneration are n...

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Veröffentlicht in:	Journal of neuroscience research 2005-07, Vol.81 (1), p.85-90
Hauptverfasser:	Yan, Xiang-Dong, Kumar, Bipin, Nahreini, Piruz, Hanson, Amy J., Prasad, Judith E., Prasad, Kedar N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology Animals antioxidants Antioxidants - pharmacology Catalase - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line, Tumor Glutathione Peroxidase - metabolism Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 Membrane Proteins Mice Nerve Degeneration - metabolism neurodegeneration Neurons - drug effects Neurons - enzymology oxidative markers Oxidative Stress - drug effects Oxidative Stress - physiology prostaglandin Prostaglandins A - physiology Superoxide Dismutase - metabolism
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