Cerebral pyruvate carboxylase flux is unaltered during bicuculline-seizures

Glutamine synthesis in the astroglia reflects the sum of neurotransmitter cycling (glutamate and γ‐aminobutyric acid [GABA]) and de novo synthesis (anaplerosis), the latter catalyzed by pyruvate carboxylase. Previous studies have shown that the glutamate plus GABA cycling flux is correlated strongly...

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Veröffentlicht in:	Journal of neuroscience research 2005-01, Vol.79 (1-2), p.128-138
Hauptverfasser:	Patel, Anant B., Chowdhury, Golam M.I., de Graaf, Robin A., Rothman, Douglas L., Shulman, Robert G., Behar, Kevin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	[2-13C]glucose Amino Acids - metabolism Analysis of Variance anaplerosis Animals Bicuculline Brain Chemistry Carbon Isotopes - metabolism Cell Fractionation - methods Cell Membrane - metabolism Cerebellum - cytology Cerebellum - drug effects Cerebellum - enzymology Citric Acid Cycle - physiology Electroencephalography - methods gamma-Aminobutyric Acid - metabolism Glucose - metabolism glutamate-glutamine cycle Magnetic Resonance Spectroscopy - methods neuronal-glial trafficking Neurons - drug effects Neurons - enzymology NMR Probability Pyruvate Carboxylase - metabolism Rats Rats, Wistar Seizures - chemically induced Seizures - enzymology Seizures - physiopathology Succinic Acid - metabolism Time Factors
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