Mitogen-activated protein kinase mediates purinergic-enhanced nerve growth factor-induced neurite outgrowth in PC12 cells

In 1999, we reported new observations that several compounds, including ATP, enhance neurite expression in PC12 cells when coapplied with nerve growth factor (NGF). Because purinergic and NGF signaling have several potential interfaces in PC12 cells, a series of experiments was conducted to elucidat...

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Veröffentlicht in:	Journal of neuroscience research 2004-10, Vol.78 (1), p.64-74
Hauptverfasser:	Behrsing, Holger Peter, Vulliet, P. Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - physiology Animals Dose-Response Relationship, Drug Drug Synergism Enzyme Inhibitors - pharmacology kinase MAPK Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Nerve Growth Factor - physiology neurite outgrowth Neurites - drug effects Neurites - physiology NGF PC12 Cells purinergic Rats
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