Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity

A methanolic extract of dried Schisandra fruit (Schisandra chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L‐glutamate in primary cultures of rat cortical cells. Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuwei...

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Veröffentlicht in:	Journal of neuroscience research 2004-05, Vol.76 (3), p.397-405
Hauptverfasser:	Kim, So Ra, Lee, Mi Kyeong, Koo, Kyung Ah, Kim, Seung Hyun, Sung, Sang Hyun, Lee, Na Gyong, Markelonis, George J., Oh, Tae H., Yang, Jae Ho, Kim, Young Choong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cyclooctanes - pharmacology dibenzocyclooctadiene lignans Dioxoles - pharmacology Dose-Response Relationship, Drug excitotoxic cell damage Glutamic Acid - toxicity glutathione defense system Intracellular Fluid - metabolism Lignans - pharmacology Neurons - drug effects Neurons - metabolism neuroprotective activity Neuroprotective Agents - pharmacology Neurotoxins - toxicity Peroxides - metabolism Phytotherapy Plant Extracts - pharmacology Polycyclic Compounds - pharmacology Rats Schisandra - chemistry Schisandra chinensis
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