Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity
A methanolic extract of dried Schisandra fruit (Schisandra chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L‐glutamate in primary cultures of rat cortical cells. Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuwei...
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| Veröffentlicht in: | Journal of neuroscience research 2004-05, Vol.76 (3), p.397-405 |
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| container_title | Journal of neuroscience research |
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| creator | Kim, So Ra Lee, Mi Kyeong Koo, Kyung Ah Kim, Seung Hyun Sung, Sang Hyun Lee, Na Gyong Markelonis, George J. Oh, Tae H. Yang, Jae Ho Kim, Young Choong |
| description | A methanolic extract of dried Schisandra fruit (Schisandra chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L‐glutamate in primary cultures of rat cortical cells. Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuweizisu C) were isolated from the methanolic extract; their protective effects against glutamate‐induced neurotoxicity were then evaluated. Among the five lignans, deoxyschisandrin, gomisin N, and wuweizisu C significantly attenuated glutamate‐induced neurotoxicity as measured by 1) an inhibition in the increase of intracellular [Ca2+]; 2) an improvement in the glutathione defense system, the level of glutathione, and the activity of glutathione peroxidase; and 3) an inhibition in the formation of cellular peroxide. These results suggest that dibenzocyclooctadiene lignans from Schisandra chinensis may possess therapeutic potential against oxidative neuronal damage induced by excitotoxin. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jnr.20089 |
| format | Article |
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Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuweizisu C) were isolated from the methanolic extract; their protective effects against glutamate‐induced neurotoxicity were then evaluated. Among the five lignans, deoxyschisandrin, gomisin N, and wuweizisu C significantly attenuated glutamate‐induced neurotoxicity as measured by 1) an inhibition in the increase of intracellular [Ca2+]; 2) an improvement in the glutathione defense system, the level of glutathione, and the activity of glutathione peroxidase; and 3) an inhibition in the formation of cellular peroxide. These results suggest that dibenzocyclooctadiene lignans from Schisandra chinensis may possess therapeutic potential against oxidative neuronal damage induced by excitotoxin. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.20089</identifier><identifier>PMID: 15079869</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Calcium - metabolism ; Cells, Cultured ; Cerebral Cortex - cytology ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Cyclooctanes - pharmacology ; dibenzocyclooctadiene lignans ; Dioxoles - pharmacology ; Dose-Response Relationship, Drug ; excitotoxic cell damage ; Glutamic Acid - toxicity ; glutathione defense system ; Intracellular Fluid - metabolism ; Lignans - pharmacology ; Neurons - drug effects ; Neurons - metabolism ; neuroprotective activity ; Neuroprotective Agents - pharmacology ; Neurotoxins - toxicity ; Peroxides - metabolism ; Phytotherapy ; Plant Extracts - pharmacology ; Polycyclic Compounds - pharmacology ; Rats ; Schisandra - chemistry ; Schisandra chinensis</subject><ispartof>Journal of neuroscience research, 2004-05, Vol.76 (3), p.397-405</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>Copyright 2004 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4259-ad5443e3ec1404603c0455f3dfba2fbf9069590b2d89c336d97c58cc2c34b3213</citedby><cites>FETCH-LOGICAL-c4259-ad5443e3ec1404603c0455f3dfba2fbf9069590b2d89c336d97c58cc2c34b3213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.20089$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.20089$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15079869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, So Ra</creatorcontrib><creatorcontrib>Lee, Mi Kyeong</creatorcontrib><creatorcontrib>Koo, Kyung Ah</creatorcontrib><creatorcontrib>Kim, Seung Hyun</creatorcontrib><creatorcontrib>Sung, Sang Hyun</creatorcontrib><creatorcontrib>Lee, Na Gyong</creatorcontrib><creatorcontrib>Markelonis, George J.</creatorcontrib><creatorcontrib>Oh, Tae H.</creatorcontrib><creatorcontrib>Yang, Jae Ho</creatorcontrib><creatorcontrib>Kim, Young Choong</creatorcontrib><title>Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>A methanolic extract of dried Schisandra fruit (Schisandra chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L‐glutamate in primary cultures of rat cortical cells. Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuweizisu C) were isolated from the methanolic extract; their protective effects against glutamate‐induced neurotoxicity were then evaluated. Among the five lignans, deoxyschisandrin, gomisin N, and wuweizisu C significantly attenuated glutamate‐induced neurotoxicity as measured by 1) an inhibition in the increase of intracellular [Ca2+]; 2) an improvement in the glutathione defense system, the level of glutathione, and the activity of glutathione peroxidase; and 3) an inhibition in the formation of cellular peroxide. These results suggest that dibenzocyclooctadiene lignans from Schisandra chinensis may possess therapeutic potential against oxidative neuronal damage induced by excitotoxin. © 2004 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Cells, Cultured</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cyclooctanes - pharmacology</subject><subject>dibenzocyclooctadiene lignans</subject><subject>Dioxoles - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>excitotoxic cell damage</subject><subject>Glutamic Acid - toxicity</subject><subject>glutathione defense system</subject><subject>Intracellular Fluid - metabolism</subject><subject>Lignans - pharmacology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>neuroprotective activity</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neurotoxins - toxicity</subject><subject>Peroxides - metabolism</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Polycyclic Compounds - pharmacology</subject><subject>Rats</subject><subject>Schisandra - chemistry</subject><subject>Schisandra chinensis</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1u1DAUha0K1A6lC14Aecsi7U1sJ-MlTH-gtEVqQUXdWM61U1w8dmU7osMD8NykzBRWrM5dfOfo6iPkVQ37NUBzcBfSfgMwl1tkVoPsKi5494zMgLVQcaibHfIi5zsAkFKwbbJTC-jkvJUz8uvQ9Tb8jLhCHyMWbZwNlnp3G3TIdEhxSa_wm8s6mKTpdAUbssv0PsVisUzpljqtKI6-jMlmGgeadKEYU3GoPUXr_Wbo1o9FL3WxlQtmRGtoiQ8OXVm9JM8H7bPd2-Qu-XJ89Hnxvjr7dPJh8fasQt4IWWkjOGeWWaw58BYYAhdiYGbodTP0g4RWCgl9Y-YSGWuN7FDMERtkvGdNzXbJm_UupphzsoPa_K9qUI8u1eRS_XE5sa_X7P3YL635R27kTcDBGvjhvF39f0mdXlw-TVbrhsvFPvxt6PRdtR3rhLq-OFE38uO788XXGyXZb-rkkVA</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Kim, So Ra</creator><creator>Lee, Mi Kyeong</creator><creator>Koo, Kyung Ah</creator><creator>Kim, Seung Hyun</creator><creator>Sung, Sang Hyun</creator><creator>Lee, Na Gyong</creator><creator>Markelonis, George J.</creator><creator>Oh, Tae H.</creator><creator>Yang, Jae Ho</creator><creator>Kim, Young Choong</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040501</creationdate><title>Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity</title><author>Kim, So Ra ; Lee, Mi Kyeong ; Koo, Kyung Ah ; Kim, Seung Hyun ; Sung, Sang Hyun ; Lee, Na Gyong ; Markelonis, George J. ; Oh, Tae H. ; Yang, Jae Ho ; Kim, Young Choong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4259-ad5443e3ec1404603c0455f3dfba2fbf9069590b2d89c336d97c58cc2c34b3213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Cells, Cultured</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cyclooctanes - pharmacology</topic><topic>dibenzocyclooctadiene lignans</topic><topic>Dioxoles - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>excitotoxic cell damage</topic><topic>Glutamic Acid - toxicity</topic><topic>glutathione defense system</topic><topic>Intracellular Fluid - metabolism</topic><topic>Lignans - pharmacology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>neuroprotective activity</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neurotoxins - toxicity</topic><topic>Peroxides - metabolism</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Polycyclic Compounds - pharmacology</topic><topic>Rats</topic><topic>Schisandra - chemistry</topic><topic>Schisandra chinensis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, So Ra</creatorcontrib><creatorcontrib>Lee, Mi Kyeong</creatorcontrib><creatorcontrib>Koo, Kyung Ah</creatorcontrib><creatorcontrib>Kim, Seung Hyun</creatorcontrib><creatorcontrib>Sung, Sang Hyun</creatorcontrib><creatorcontrib>Lee, Na Gyong</creatorcontrib><creatorcontrib>Markelonis, George J.</creatorcontrib><creatorcontrib>Oh, Tae H.</creatorcontrib><creatorcontrib>Yang, Jae Ho</creatorcontrib><creatorcontrib>Kim, Young Choong</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, So Ra</au><au>Lee, Mi Kyeong</au><au>Koo, Kyung Ah</au><au>Kim, Seung Hyun</au><au>Sung, Sang Hyun</au><au>Lee, Na Gyong</au><au>Markelonis, George J.</au><au>Oh, Tae H.</au><au>Yang, Jae Ho</au><au>Kim, Young Choong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>76</volume><issue>3</issue><spage>397</spage><epage>405</epage><pages>397-405</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>A methanolic extract of dried Schisandra fruit (Schisandra chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L‐glutamate in primary cultures of rat cortical cells. Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuweizisu C) were isolated from the methanolic extract; their protective effects against glutamate‐induced neurotoxicity were then evaluated. Among the five lignans, deoxyschisandrin, gomisin N, and wuweizisu C significantly attenuated glutamate‐induced neurotoxicity as measured by 1) an inhibition in the increase of intracellular [Ca2+]; 2) an improvement in the glutathione defense system, the level of glutathione, and the activity of glutathione peroxidase; and 3) an inhibition in the formation of cellular peroxide. These results suggest that dibenzocyclooctadiene lignans from Schisandra chinensis may possess therapeutic potential against oxidative neuronal damage induced by excitotoxin. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15079869</pmid><doi>10.1002/jnr.20089</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Calcium - metabolism Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cyclooctanes - pharmacology dibenzocyclooctadiene lignans Dioxoles - pharmacology Dose-Response Relationship, Drug excitotoxic cell damage Glutamic Acid - toxicity glutathione defense system Intracellular Fluid - metabolism Lignans - pharmacology Neurons - drug effects Neurons - metabolism neuroprotective activity Neuroprotective Agents - pharmacology Neurotoxins - toxicity Peroxides - metabolism Phytotherapy Plant Extracts - pharmacology Polycyclic Compounds - pharmacology Rats Schisandra - chemistry Schisandra chinensis |
| title | Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity |
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