Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity

We examined the effects of bisphenol A, an endocrine disruptor, on rat behavioral and cellular responses. Single intracisternal administration of bisphenol A (0.2‐20 μg) into 5‐day‐old male Wistar rats caused significant hyperactivity at 4–5 weeks of age. Rats were about 1.6‐fold more active in the...

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Veröffentlicht in:	Journal of neuroscience research 2004-05, Vol.76 (3), p.423-433
Hauptverfasser:	Ishido, Masami, Masuo, Yoshinori, Kunimoto, Manabu, Oka, Syuichi, Morita, Masatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Benzhydryl Compounds bisphenol A DNA array Dopamine Plasma Membrane Transport Proteins Dose-Response Relationship, Drug endocrine disruptors Estrogens, Non-Steroidal - administration & dosage Female hyperactivity Hyperkinesis - chemically induced Hyperkinesis - metabolism Injections, Intraventricular Male Membrane Glycoproteins Membrane Transport Proteins - drug effects Membrane Transport Proteins - metabolism Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - metabolism Phenols - administration & dosage Rats Rats, Wistar Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - metabolism Receptors, Dopamine D4 Subarachnoid Space Tyrosine 3-Monooxygenase - drug effects Tyrosine 3-Monooxygenase - metabolism tyrosine hydroxylase
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