Pituitary adenylate cyclase-activating polypeptide prevents C2-ceramide-induced apoptosis of cerebellar granule cells

The sphingolipid metabolites, ceramides, are critical mediators of the cellular stress response and play an important role in the control of programmed cell death. In particular, ceramides have been shown to induce apoptosis of cerebellar granule cells. We show that pituitary adenylate cyclase‐activ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neuroscience research 2003-05, Vol.72 (3), p.303-316
Hauptverfasser:	Vaudry, David, Falluel-Morel, Anthony, Basille, Magali, Pamantung, Tommy F., Fontaine, Marc, Fournier, Alain, Vaudry, Hubert, Gonzalez, Bruno J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - drug effects Adenylyl Cyclases - genetics Adenylyl Cyclases - metabolism Animals Apoptosis - drug effects Blotting, Western caspases Caspases - drug effects Caspases - metabolism Cell Survival - drug effects Cells, Cultured Ceramides - toxicity Cerebellum - drug effects Cerebellum - enzymology development DNA Fragmentation - drug effects Dose-Response Relationship, Drug Gene Expression Regulation - drug effects MAP-kinases Mitogen-Activated Protein Kinase Kinases - drug effects Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism neuropeptides Neuropeptides - antagonists & inhibitors Neuropeptides - pharmacology Neuroprotective Agents - antagonists & inhibitors Neuroprotective Agents - pharmacology Phosphorylation Pituitary Adenylate Cyclase-Activating Polypeptide Rats Rats, Wistar Signal Transduction - drug effects sphingolipids
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!