Five-minute knee MRI for simultaneous morphometry and T 2 relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T
Biomarkers for assessing osteoarthritis activity necessitate multiple MRI sequences with long acquisition times. To perform 5-minute simultaneous morphometry (thickness/volume measurements) and T relaxometry of both cartilage and meniscus, and semiquantitative MRI Osteoarthritis Knee Scoring (MOAKS)...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2018-05, Vol.47 (5), p.1328-1341 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Chaudhari, Akshay S Black, Marianne S Eijgenraam, Susanne Wirth, Wolfgang Maschek, Susanne Sveinsson, Bragi Eckstein, Felix Oei, Edwin H G Gold, Garry E Hargreaves, Brian A |
| description | Biomarkers for assessing osteoarthritis activity necessitate multiple MRI sequences with long acquisition times.
To perform 5-minute simultaneous morphometry (thickness/volume measurements) and T
relaxometry of both cartilage and meniscus, and semiquantitative MRI Osteoarthritis Knee Scoring (MOAKS).
Prospective.
Fifteen healthy volunteers for morphometry and T
measurements, and 15 patients (five each Kellgren-Lawrence grades 0/2/3) for MOAKS assessment.
A 5-minute double-echo steady-state (DESS) sequence was evaluated for generating quantitative and semiquantitative osteoarthritis biomarkers at 3T.
Flip angle simulations evaluated tissue signals and sensitivity of T
measurements. Morphometry and T
reproducibility was compared against morphometry-optimized and relaxometry-optimized sequences. Repeatability was assessed by scanning five volunteers twice. MOAKS reproducibility was compared to MOAKS derived from a clinical knee MRI protocol by two readers.
Coefficients of variation (CVs), concordance confidence intervals (CCI), and Wilcoxon signed-rank tests compared morphometry and relaxometry measurements with their reference standards. DESS MOAKS positive percent agreement (PPA), negative percentage agreement (NPA), and interreader agreement was calculated using the clinical protocol as a reference. Biomarker variations between Kellgren-Lawrence groups were evaluated using Wilcoxon rank-sum tests.
Cartilage thickness (P = 0.65), cartilage T
(P = 0.69), and meniscus T
(P = 0.06) did not significantly differ from their reference standard (with a 20° DESS flip angle). DESS slightly overestimated meniscus volume (P < 0.001). Accuracy and repeatability CVs were |
| doi_str_mv | 10.1002/jmri.25883 |
| format | Article |
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To perform 5-minute simultaneous morphometry (thickness/volume measurements) and T
relaxometry of both cartilage and meniscus, and semiquantitative MRI Osteoarthritis Knee Scoring (MOAKS).
Prospective.
Fifteen healthy volunteers for morphometry and T
measurements, and 15 patients (five each Kellgren-Lawrence grades 0/2/3) for MOAKS assessment.
A 5-minute double-echo steady-state (DESS) sequence was evaluated for generating quantitative and semiquantitative osteoarthritis biomarkers at 3T.
Flip angle simulations evaluated tissue signals and sensitivity of T
measurements. Morphometry and T
reproducibility was compared against morphometry-optimized and relaxometry-optimized sequences. Repeatability was assessed by scanning five volunteers twice. MOAKS reproducibility was compared to MOAKS derived from a clinical knee MRI protocol by two readers.
Coefficients of variation (CVs), concordance confidence intervals (CCI), and Wilcoxon signed-rank tests compared morphometry and relaxometry measurements with their reference standards. DESS MOAKS positive percent agreement (PPA), negative percentage agreement (NPA), and interreader agreement was calculated using the clinical protocol as a reference. Biomarker variations between Kellgren-Lawrence groups were evaluated using Wilcoxon rank-sum tests.
Cartilage thickness (P = 0.65), cartilage T
(P = 0.69), and meniscus T
(P = 0.06) did not significantly differ from their reference standard (with a 20° DESS flip angle). DESS slightly overestimated meniscus volume (P < 0.001). Accuracy and repeatability CVs were <3.3%, except the meniscus T
accuracy (7.6%). DESS MOAKS had substantial interreader agreement and high PPA/NPA values of 87%/90%. Bone marrow lesions and menisci had slightly lower PPAs. Cartilage and meniscus T
, and MOAKS (cartilage surface area, osteophytes, cysts, and total score) was higher in Kellgren-Lawrence groups 2 and 3 than group 0 (P < 0.05).
The 5-minute DESS sequence permits MOAKS assessment for a majority of tissues, along with repeatable and reproducible simultaneous cartilage and meniscus T
relaxometry and morphometry measurements.
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1328-1341.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.25883</identifier><identifier>PMID: 29090500</identifier><language>eng</language><publisher>United States</publisher><ispartof>Journal of magnetic resonance imaging, 2018-05, Vol.47 (5), p.1328-1341</ispartof><rights>2017 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c254t-395d5df69281aebe9fb5b9ffd07ce08ef6aa70f868dabfe4762995f7c6f258033</citedby><cites>FETCH-LOGICAL-c254t-395d5df69281aebe9fb5b9ffd07ce08ef6aa70f868dabfe4762995f7c6f258033</cites><orcidid>0000-0002-3667-6796</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29090500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaudhari, Akshay S</creatorcontrib><creatorcontrib>Black, Marianne S</creatorcontrib><creatorcontrib>Eijgenraam, Susanne</creatorcontrib><creatorcontrib>Wirth, Wolfgang</creatorcontrib><creatorcontrib>Maschek, Susanne</creatorcontrib><creatorcontrib>Sveinsson, Bragi</creatorcontrib><creatorcontrib>Eckstein, Felix</creatorcontrib><creatorcontrib>Oei, Edwin H G</creatorcontrib><creatorcontrib>Gold, Garry E</creatorcontrib><creatorcontrib>Hargreaves, Brian A</creatorcontrib><title>Five-minute knee MRI for simultaneous morphometry and T 2 relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Biomarkers for assessing osteoarthritis activity necessitate multiple MRI sequences with long acquisition times.
To perform 5-minute simultaneous morphometry (thickness/volume measurements) and T
relaxometry of both cartilage and meniscus, and semiquantitative MRI Osteoarthritis Knee Scoring (MOAKS).
Prospective.
Fifteen healthy volunteers for morphometry and T
measurements, and 15 patients (five each Kellgren-Lawrence grades 0/2/3) for MOAKS assessment.
A 5-minute double-echo steady-state (DESS) sequence was evaluated for generating quantitative and semiquantitative osteoarthritis biomarkers at 3T.
Flip angle simulations evaluated tissue signals and sensitivity of T
measurements. Morphometry and T
reproducibility was compared against morphometry-optimized and relaxometry-optimized sequences. Repeatability was assessed by scanning five volunteers twice. MOAKS reproducibility was compared to MOAKS derived from a clinical knee MRI protocol by two readers.
Coefficients of variation (CVs), concordance confidence intervals (CCI), and Wilcoxon signed-rank tests compared morphometry and relaxometry measurements with their reference standards. DESS MOAKS positive percent agreement (PPA), negative percentage agreement (NPA), and interreader agreement was calculated using the clinical protocol as a reference. Biomarker variations between Kellgren-Lawrence groups were evaluated using Wilcoxon rank-sum tests.
Cartilage thickness (P = 0.65), cartilage T
(P = 0.69), and meniscus T
(P = 0.06) did not significantly differ from their reference standard (with a 20° DESS flip angle). DESS slightly overestimated meniscus volume (P < 0.001). Accuracy and repeatability CVs were <3.3%, except the meniscus T
accuracy (7.6%). DESS MOAKS had substantial interreader agreement and high PPA/NPA values of 87%/90%. Bone marrow lesions and menisci had slightly lower PPAs. Cartilage and meniscus T
, and MOAKS (cartilage surface area, osteophytes, cysts, and total score) was higher in Kellgren-Lawrence groups 2 and 3 than group 0 (P < 0.05).
The 5-minute DESS sequence permits MOAKS assessment for a majority of tissues, along with repeatable and reproducible simultaneous cartilage and meniscus T
relaxometry and morphometry measurements.
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1328-1341.</description><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNo9kEFv1DAQhS0EoqVw4QegOSOlTJx1Eh9RRaFSERJaztEkHm9d4nixnYr9Z_w8vNvCaeaN3nsjfUK8rfGyRpQf7n10l1L1ffNMnNdKyqqI9nnZUTVV3WN3Jl6ldI-IWm_US3EmNWpUiOfiz7V74Mq7Zc0MPxdm-Pr9BmyIkJxf50wLhzWBD3F_FzzneABaDGxBQuSZfj_dgoWJYnYz7fhk8Ly4NJXkUZzq2LtfKy3ZZcrlJ0QyLsxh5yaagVLilEoow5rcsgMT1nHmiqe7AG6BlJnMoUolW_ozNNvX4oWlOfGbp3khflx_2l59qW6_fb65-nhbTVJtctVoZZSxrZZ9TTyytqMatbUGu4mxZ9sSdWj7tjc0Wt50rdRa2W5qbYGITXMh3j_2TjGkFNkO--g8xcNQ43DEPxzxDyf8xfzu0bxfR8_mv_Uf7-YvspuGdA</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Chaudhari, Akshay S</creator><creator>Black, Marianne S</creator><creator>Eijgenraam, Susanne</creator><creator>Wirth, Wolfgang</creator><creator>Maschek, Susanne</creator><creator>Sveinsson, Bragi</creator><creator>Eckstein, Felix</creator><creator>Oei, Edwin H G</creator><creator>Gold, Garry E</creator><creator>Hargreaves, Brian A</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-3667-6796</orcidid></search><sort><creationdate>201805</creationdate><title>Five-minute knee MRI for simultaneous morphometry and T 2 relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T</title><author>Chaudhari, Akshay S ; Black, Marianne S ; Eijgenraam, Susanne ; Wirth, Wolfgang ; Maschek, Susanne ; Sveinsson, Bragi ; Eckstein, Felix ; Oei, Edwin H G ; Gold, Garry E ; Hargreaves, Brian A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-395d5df69281aebe9fb5b9ffd07ce08ef6aa70f868dabfe4762995f7c6f258033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaudhari, Akshay S</creatorcontrib><creatorcontrib>Black, Marianne S</creatorcontrib><creatorcontrib>Eijgenraam, Susanne</creatorcontrib><creatorcontrib>Wirth, Wolfgang</creatorcontrib><creatorcontrib>Maschek, Susanne</creatorcontrib><creatorcontrib>Sveinsson, Bragi</creatorcontrib><creatorcontrib>Eckstein, Felix</creatorcontrib><creatorcontrib>Oei, Edwin H G</creatorcontrib><creatorcontrib>Gold, Garry E</creatorcontrib><creatorcontrib>Hargreaves, Brian A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaudhari, Akshay S</au><au>Black, Marianne S</au><au>Eijgenraam, Susanne</au><au>Wirth, Wolfgang</au><au>Maschek, Susanne</au><au>Sveinsson, Bragi</au><au>Eckstein, Felix</au><au>Oei, Edwin H G</au><au>Gold, Garry E</au><au>Hargreaves, Brian A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Five-minute knee MRI for simultaneous morphometry and T 2 relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2018-05</date><risdate>2018</risdate><volume>47</volume><issue>5</issue><spage>1328</spage><epage>1341</epage><pages>1328-1341</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Biomarkers for assessing osteoarthritis activity necessitate multiple MRI sequences with long acquisition times.
To perform 5-minute simultaneous morphometry (thickness/volume measurements) and T
relaxometry of both cartilage and meniscus, and semiquantitative MRI Osteoarthritis Knee Scoring (MOAKS).
Prospective.
Fifteen healthy volunteers for morphometry and T
measurements, and 15 patients (five each Kellgren-Lawrence grades 0/2/3) for MOAKS assessment.
A 5-minute double-echo steady-state (DESS) sequence was evaluated for generating quantitative and semiquantitative osteoarthritis biomarkers at 3T.
Flip angle simulations evaluated tissue signals and sensitivity of T
measurements. Morphometry and T
reproducibility was compared against morphometry-optimized and relaxometry-optimized sequences. Repeatability was assessed by scanning five volunteers twice. MOAKS reproducibility was compared to MOAKS derived from a clinical knee MRI protocol by two readers.
Coefficients of variation (CVs), concordance confidence intervals (CCI), and Wilcoxon signed-rank tests compared morphometry and relaxometry measurements with their reference standards. DESS MOAKS positive percent agreement (PPA), negative percentage agreement (NPA), and interreader agreement was calculated using the clinical protocol as a reference. Biomarker variations between Kellgren-Lawrence groups were evaluated using Wilcoxon rank-sum tests.
Cartilage thickness (P = 0.65), cartilage T
(P = 0.69), and meniscus T
(P = 0.06) did not significantly differ from their reference standard (with a 20° DESS flip angle). DESS slightly overestimated meniscus volume (P < 0.001). Accuracy and repeatability CVs were <3.3%, except the meniscus T
accuracy (7.6%). DESS MOAKS had substantial interreader agreement and high PPA/NPA values of 87%/90%. Bone marrow lesions and menisci had slightly lower PPAs. Cartilage and meniscus T
, and MOAKS (cartilage surface area, osteophytes, cysts, and total score) was higher in Kellgren-Lawrence groups 2 and 3 than group 0 (P < 0.05).
The 5-minute DESS sequence permits MOAKS assessment for a majority of tissues, along with repeatable and reproducible simultaneous cartilage and meniscus T
relaxometry and morphometry measurements.
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1328-1341.</abstract><cop>United States</cop><pmid>29090500</pmid><doi>10.1002/jmri.25883</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-3667-6796</orcidid></addata></record> |
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| title | Five-minute knee MRI for simultaneous morphometry and T 2 relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T |
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