Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T 2 mapping of talar osteochondral lesions: Indicators of clinical outcomes

To evaluate the utility of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T mapping in evaluation of type II osteochondral lesions (OCLs) of the talus and define cutoff values for identifying patients with good/poor clinical outcomes. 28 patients (mean age, 42.3 years) underwent T mapping and dGEMRIC at least 1.5 years (mean duration, 3.5 years) after microfracture (n = 12) or conservative (n = 16) treatment for type II OCL. Clinical outcomes were considered good with an American Orthopedic Foot and Ankle Society score ≥80. The T /T -values and indices of repair tissue (RT; cartilage above the OCL) were compared to those of the adjacent normal cartilage (NC) by region-of-interest analysis. The ability of the two methods to discriminate RT from NC was determined by area under the receiver operating characteristics curve (AUC) analysis. The Youden index was maximized for T /T measures for identifying cutoff values indicative of good/poor clinical outcomes. Repair tissue exhibited lower dGEMRIC values (629.83 vs. 738.51 msec) and higher T values (62.07 vs. 40.69 msec) than NC (P < 0.001). T mapping exhibited greater AUC than dGEMRIC (0.88 vs. 0.69; P = 0.0398). All T measures exhibited higher maximized Youden indices than the corresponding T measures. The highest maximized Youden index for T was observed at a cutoff value of 84 msec (sensitivity, 78%; specificity, 83%). While T mapping is superior to dGEMRIC in discriminating RT, the latter better identifies good/poor clinical outcomes in patients with type II talar OCL. 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1601-1610.