Confounding neurodegenerative effects of manganese for in vivo MR imaging in rat models of brain insults

Purpose: To examine the long‐term consequences of manganese exposure due to the use of manganese‐enhanced magnetic resonance imaging (MEMRI) in a model of closed head injury, the fluid‐percussion injury (FPI) model. Materials and Methods: Two groups of adult male Wistar rats (n = 72) were studied wi...

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Veröffentlicht in:	Journal of magnetic resonance imaging 2011-10, Vol.34 (4), p.774-784
Hauptverfasser:	Bouilleret, Viviane, Cardamone, Lisa, Liu, Cyril, Koe, Amelia S., Fang, Ke, Williams, John P., Myers, Damian E., O'Brien, Terence J., Jones, Nigel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Brain Injuries - diagnosis Brain Injuries - pathology Brain Mapping - methods Contrast Media - adverse effects Contrast Media - pharmacology Disease Models, Animal Electroencephalography - methods Image Enhancement - methods Longitudinal Studies Magnetic Resonance Imaging - adverse effects Magnetic Resonance Imaging - methods Male Manganese Compounds - adverse effects Manganese Poisoning - diagnosis manganese toxicity manganese-enhanced MRI Motor Activity - drug effects neurodegeneration Neurodegenerative Diseases - chemically induced Neurodegenerative Diseases - diagnosis Random Allocation Rats Rats, Wistar Reference Values traumatic brain injury
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