Confounding neurodegenerative effects of manganese for in vivo MR imaging in rat models of brain insults
Purpose: To examine the long‐term consequences of manganese exposure due to the use of manganese‐enhanced magnetic resonance imaging (MEMRI) in a model of closed head injury, the fluid‐percussion injury (FPI) model. Materials and Methods: Two groups of adult male Wistar rats (n = 72) were studied wi...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2011-10, Vol.34 (4), p.774-784 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Bouilleret, Viviane Cardamone, Lisa Liu, Cyril Koe, Amelia S. Fang, Ke Williams, John P. Myers, Damian E. O'Brien, Terence J. Jones, Nigel C. |
| description | Purpose:
To examine the long‐term consequences of manganese exposure due to the use of manganese‐enhanced magnetic resonance imaging (MEMRI) in a model of closed head injury, the fluid‐percussion injury (FPI) model.
Materials and Methods:
Two groups of adult male Wistar rats (n = 72) were studied with either MEMRI, whereby rats receive MnCl2 (100 mg/kg intraperitoneally) 24 hours prior to scanning, or standard MRI (sMRI) with no contrast agent. Rats from both groups underwent FPI or sham injury and were longitudinally assessed for 6 months for neurological toxicity using behavioral tests, EEG recording, and MRI scanning.
Results:
Regardless of whether they received FPI, MEMRI animals showed progressive signs of cerebral toxicity compared with sMRI rats, including significantly reduced weight gain, progressive brain volume decrease, and increased anxiety and depressive‐like behaviors.
Conclusion:
Long‐term structural and functional consequences of using manganese as a contrast agent for MRI can confound experimental outcomes and must be taken into account when designing longitudinal imaging studies using manganese‐enhanced MRI. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.22669 |
| format | Article |
| fullrecord | <record><control><sourceid>istex_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_jmri_22669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_WNG_29D851LL_Z</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4029-f35b464404860bc0bf6d30690ef4e8097956723acc6abbd7fa55097f3e09d19b3</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMoPqobf4BkLYzeZCaZyVLqm1ZBFMFNyMzc1GgnI0lb9d-bWnXpKpfD9x3CIWSfwRED4McvXXBHnEup1sg2E5xnXFRyPd0g8oxVUG6RnRhfAECpQmySLc5KqZRU2-R52Hvbz33r_IR6nIe-xQl6DGbmFkjRWmxmkfaWdsZPjMeI1PaBOk8XbtHT8R11nZks7RQli3apYfpt1MGkzPk4n87iLtmwZhpx7-cdkIfzs_vhZTa6vbganoyypgCuMpuLupBFAUUloW6gtrLNQSpAW2AFqlRCljw3TSNNXbelNUKk1OYIqmWqzgfkcNXbhD7GgFa_hfTD8KkZ6OVcejmX_p4rwQcr-G1ed9j-ob_7JICtgHc3xc9_qvT1-O7qtzRbOS7O8OPPMeFVyzIvhX68udBcnVaCjUb6Kf8CDhmFqg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Confounding neurodegenerative effects of manganese for in vivo MR imaging in rat models of brain insults</title><source>MEDLINE</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Bouilleret, Viviane ; Cardamone, Lisa ; Liu, Cyril ; Koe, Amelia S. ; Fang, Ke ; Williams, John P. ; Myers, Damian E. ; O'Brien, Terence J. ; Jones, Nigel C.</creator><creatorcontrib>Bouilleret, Viviane ; Cardamone, Lisa ; Liu, Cyril ; Koe, Amelia S. ; Fang, Ke ; Williams, John P. ; Myers, Damian E. ; O'Brien, Terence J. ; Jones, Nigel C.</creatorcontrib><description>Purpose:
To examine the long‐term consequences of manganese exposure due to the use of manganese‐enhanced magnetic resonance imaging (MEMRI) in a model of closed head injury, the fluid‐percussion injury (FPI) model.
Materials and Methods:
Two groups of adult male Wistar rats (n = 72) were studied with either MEMRI, whereby rats receive MnCl2 (100 mg/kg intraperitoneally) 24 hours prior to scanning, or standard MRI (sMRI) with no contrast agent. Rats from both groups underwent FPI or sham injury and were longitudinally assessed for 6 months for neurological toxicity using behavioral tests, EEG recording, and MRI scanning.
Results:
Regardless of whether they received FPI, MEMRI animals showed progressive signs of cerebral toxicity compared with sMRI rats, including significantly reduced weight gain, progressive brain volume decrease, and increased anxiety and depressive‐like behaviors.
Conclusion:
Long‐term structural and functional consequences of using manganese as a contrast agent for MRI can confound experimental outcomes and must be taken into account when designing longitudinal imaging studies using manganese‐enhanced MRI. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.22669</identifier><identifier>PMID: 21769969</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Behavior, Animal - drug effects ; Brain Injuries - diagnosis ; Brain Injuries - pathology ; Brain Mapping - methods ; Contrast Media - adverse effects ; Contrast Media - pharmacology ; Disease Models, Animal ; Electroencephalography - methods ; Image Enhancement - methods ; Longitudinal Studies ; Magnetic Resonance Imaging - adverse effects ; Magnetic Resonance Imaging - methods ; Male ; Manganese Compounds - adverse effects ; Manganese Poisoning - diagnosis ; manganese toxicity ; manganese-enhanced MRI ; Motor Activity - drug effects ; neurodegeneration ; Neurodegenerative Diseases - chemically induced ; Neurodegenerative Diseases - diagnosis ; Random Allocation ; Rats ; Rats, Wistar ; Reference Values ; traumatic brain injury</subject><ispartof>Journal of magnetic resonance imaging, 2011-10, Vol.34 (4), p.774-784</ispartof><rights>Copyright © 2011 Wiley‐Liss, Inc.</rights><rights>Copyright © 2011 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4029-f35b464404860bc0bf6d30690ef4e8097956723acc6abbd7fa55097f3e09d19b3</citedby><cites>FETCH-LOGICAL-c4029-f35b464404860bc0bf6d30690ef4e8097956723acc6abbd7fa55097f3e09d19b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.22669$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.22669$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21769969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouilleret, Viviane</creatorcontrib><creatorcontrib>Cardamone, Lisa</creatorcontrib><creatorcontrib>Liu, Cyril</creatorcontrib><creatorcontrib>Koe, Amelia S.</creatorcontrib><creatorcontrib>Fang, Ke</creatorcontrib><creatorcontrib>Williams, John P.</creatorcontrib><creatorcontrib>Myers, Damian E.</creatorcontrib><creatorcontrib>O'Brien, Terence J.</creatorcontrib><creatorcontrib>Jones, Nigel C.</creatorcontrib><title>Confounding neurodegenerative effects of manganese for in vivo MR imaging in rat models of brain insults</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose:
To examine the long‐term consequences of manganese exposure due to the use of manganese‐enhanced magnetic resonance imaging (MEMRI) in a model of closed head injury, the fluid‐percussion injury (FPI) model.
Materials and Methods:
Two groups of adult male Wistar rats (n = 72) were studied with either MEMRI, whereby rats receive MnCl2 (100 mg/kg intraperitoneally) 24 hours prior to scanning, or standard MRI (sMRI) with no contrast agent. Rats from both groups underwent FPI or sham injury and were longitudinally assessed for 6 months for neurological toxicity using behavioral tests, EEG recording, and MRI scanning.
Results:
Regardless of whether they received FPI, MEMRI animals showed progressive signs of cerebral toxicity compared with sMRI rats, including significantly reduced weight gain, progressive brain volume decrease, and increased anxiety and depressive‐like behaviors.
Conclusion:
Long‐term structural and functional consequences of using manganese as a contrast agent for MRI can confound experimental outcomes and must be taken into account when designing longitudinal imaging studies using manganese‐enhanced MRI. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Brain Injuries - diagnosis</subject><subject>Brain Injuries - pathology</subject><subject>Brain Mapping - methods</subject><subject>Contrast Media - adverse effects</subject><subject>Contrast Media - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Electroencephalography - methods</subject><subject>Image Enhancement - methods</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging - adverse effects</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Manganese Compounds - adverse effects</subject><subject>Manganese Poisoning - diagnosis</subject><subject>manganese toxicity</subject><subject>manganese-enhanced MRI</subject><subject>Motor Activity - drug effects</subject><subject>neurodegeneration</subject><subject>Neurodegenerative Diseases - chemically induced</subject><subject>Neurodegenerative Diseases - diagnosis</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reference Values</subject><subject>traumatic brain injury</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMoPqobf4BkLYzeZCaZyVLqm1ZBFMFNyMzc1GgnI0lb9d-bWnXpKpfD9x3CIWSfwRED4McvXXBHnEup1sg2E5xnXFRyPd0g8oxVUG6RnRhfAECpQmySLc5KqZRU2-R52Hvbz33r_IR6nIe-xQl6DGbmFkjRWmxmkfaWdsZPjMeI1PaBOk8XbtHT8R11nZks7RQli3apYfpt1MGkzPk4n87iLtmwZhpx7-cdkIfzs_vhZTa6vbganoyypgCuMpuLupBFAUUloW6gtrLNQSpAW2AFqlRCljw3TSNNXbelNUKk1OYIqmWqzgfkcNXbhD7GgFa_hfTD8KkZ6OVcejmX_p4rwQcr-G1ed9j-ob_7JICtgHc3xc9_qvT1-O7qtzRbOS7O8OPPMeFVyzIvhX68udBcnVaCjUb6Kf8CDhmFqg</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Bouilleret, Viviane</creator><creator>Cardamone, Lisa</creator><creator>Liu, Cyril</creator><creator>Koe, Amelia S.</creator><creator>Fang, Ke</creator><creator>Williams, John P.</creator><creator>Myers, Damian E.</creator><creator>O'Brien, Terence J.</creator><creator>Jones, Nigel C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201110</creationdate><title>Confounding neurodegenerative effects of manganese for in vivo MR imaging in rat models of brain insults</title><author>Bouilleret, Viviane ; Cardamone, Lisa ; Liu, Cyril ; Koe, Amelia S. ; Fang, Ke ; Williams, John P. ; Myers, Damian E. ; O'Brien, Terence J. ; Jones, Nigel C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4029-f35b464404860bc0bf6d30690ef4e8097956723acc6abbd7fa55097f3e09d19b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Brain Injuries - diagnosis</topic><topic>Brain Injuries - pathology</topic><topic>Brain Mapping - methods</topic><topic>Contrast Media - adverse effects</topic><topic>Contrast Media - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Electroencephalography - methods</topic><topic>Image Enhancement - methods</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging - adverse effects</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Manganese Compounds - adverse effects</topic><topic>Manganese Poisoning - diagnosis</topic><topic>manganese toxicity</topic><topic>manganese-enhanced MRI</topic><topic>Motor Activity - drug effects</topic><topic>neurodegeneration</topic><topic>Neurodegenerative Diseases - chemically induced</topic><topic>Neurodegenerative Diseases - diagnosis</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reference Values</topic><topic>traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouilleret, Viviane</creatorcontrib><creatorcontrib>Cardamone, Lisa</creatorcontrib><creatorcontrib>Liu, Cyril</creatorcontrib><creatorcontrib>Koe, Amelia S.</creatorcontrib><creatorcontrib>Fang, Ke</creatorcontrib><creatorcontrib>Williams, John P.</creatorcontrib><creatorcontrib>Myers, Damian E.</creatorcontrib><creatorcontrib>O'Brien, Terence J.</creatorcontrib><creatorcontrib>Jones, Nigel C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouilleret, Viviane</au><au>Cardamone, Lisa</au><au>Liu, Cyril</au><au>Koe, Amelia S.</au><au>Fang, Ke</au><au>Williams, John P.</au><au>Myers, Damian E.</au><au>O'Brien, Terence J.</au><au>Jones, Nigel C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Confounding neurodegenerative effects of manganese for in vivo MR imaging in rat models of brain insults</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2011-10</date><risdate>2011</risdate><volume>34</volume><issue>4</issue><spage>774</spage><epage>784</epage><pages>774-784</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose:
To examine the long‐term consequences of manganese exposure due to the use of manganese‐enhanced magnetic resonance imaging (MEMRI) in a model of closed head injury, the fluid‐percussion injury (FPI) model.
Materials and Methods:
Two groups of adult male Wistar rats (n = 72) were studied with either MEMRI, whereby rats receive MnCl2 (100 mg/kg intraperitoneally) 24 hours prior to scanning, or standard MRI (sMRI) with no contrast agent. Rats from both groups underwent FPI or sham injury and were longitudinally assessed for 6 months for neurological toxicity using behavioral tests, EEG recording, and MRI scanning.
Results:
Regardless of whether they received FPI, MEMRI animals showed progressive signs of cerebral toxicity compared with sMRI rats, including significantly reduced weight gain, progressive brain volume decrease, and increased anxiety and depressive‐like behaviors.
Conclusion:
Long‐term structural and functional consequences of using manganese as a contrast agent for MRI can confound experimental outcomes and must be taken into account when designing longitudinal imaging studies using manganese‐enhanced MRI. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21769969</pmid><doi>10.1002/jmri.22669</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Animals Behavior, Animal - drug effects Brain Injuries - diagnosis Brain Injuries - pathology Brain Mapping - methods Contrast Media - adverse effects Contrast Media - pharmacology Disease Models, Animal Electroencephalography - methods Image Enhancement - methods Longitudinal Studies Magnetic Resonance Imaging - adverse effects Magnetic Resonance Imaging - methods Male Manganese Compounds - adverse effects Manganese Poisoning - diagnosis manganese toxicity manganese-enhanced MRI Motor Activity - drug effects neurodegeneration Neurodegenerative Diseases - chemically induced Neurodegenerative Diseases - diagnosis Random Allocation Rats Rats, Wistar Reference Values traumatic brain injury |
| title | Confounding neurodegenerative effects of manganese for in vivo MR imaging in rat models of brain insults |
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