Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study
Purpose To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium‐based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephro...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2009-08, Vol.30 (2), p.374-383 |
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| creator | Pietsch, Hubertus Pering, Christiane Lengsfeld, Philipp Walter, Jakob Steger-Hartmann, Thomas Golfier, Sven Frenzel, Thomas Hütter, Joachim Weinmann, Hans-Joachim Sieber, Martin A. |
| description | Purpose
To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium‐based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF).
Materials and Methods
In the Zn supplementation study, rats were injected with Gadodiamide, Omniscan, and Magnevist with or without Zn supplementation. In the Zn depletion study, animals were kept on a Zn‐deficient diet or a special control diet and received injections of Omniscan, OptiMARK, Magnevist, Gadovist, and Gd‐EDTA. Gd, Zn, and Cu concentrations in tissue were measured and histology of the skin was performed.
Results
As seen in earlier studies, a difference in Gd concentration in the skin was observed following treatment with the different GBCAs. High Gd concentration in the skin correlated with the occurrence of NSF‐like skin lesions. We observed no differences in the occurrence of skin lesions between the Zn supplementation and the Zn‐deficient groups compared to their respective control groups.
Conclusion
We found no significant effect of Zn on the initiation of NSF‐like skin lesions. The results further support data from previous studies highlighting the importance of complex stability of the investigated GBCAs. J. Magn. Reson. Imaging 2009;30:374–383. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jmri.21845 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_jmri_21845</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JMRI21845</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4015-5cbc0eab8ed3d941fb178bbc51a83185b635ab68f0469d0244adf613487de6243</originalsourceid><addsrcrecordid>eNp9kM1OwzAQhC0EoqVw4QFQzkgpdmI7DrdSlVLUAuJHSFws23HAbZpUdgKUpydpCtw47Wjn29FqADhGsI8gDM7mS2v6AWKY7IAuIkHgB4TR3VpDEvqIwagDDpybQwjjGJN90EExDeI4Yl3wMnoXWSVKk7965Zv2bJFpr0i9L5Mrz-SbXaFUZa3O1cZJjbSFM67RjesWJj_3Bt7KapWZ3CiRea6skvUh2EtF5vTRdvbA0-XocXjlT2_Hk-Fg6isMEfGJkgpqIZlOwiTGKJUoYlIqggQLESOShkRIylKIaZzAAGORpBSFmEWJpgEOe-C0zVX1X87qlK-sWQq75gjypiDeFMQ3BdXwSQuvKrnUyR-6baQGUAt8mEyv_4ni17P7yU-o394YV-rP3xthF5xGYUT4882YX9xNGXqghM_Cb-g2gAc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study</title><source>MEDLINE</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Pietsch, Hubertus ; Pering, Christiane ; Lengsfeld, Philipp ; Walter, Jakob ; Steger-Hartmann, Thomas ; Golfier, Sven ; Frenzel, Thomas ; Hütter, Joachim ; Weinmann, Hans-Joachim ; Sieber, Martin A.</creator><creatorcontrib>Pietsch, Hubertus ; Pering, Christiane ; Lengsfeld, Philipp ; Walter, Jakob ; Steger-Hartmann, Thomas ; Golfier, Sven ; Frenzel, Thomas ; Hütter, Joachim ; Weinmann, Hans-Joachim ; Sieber, Martin A.</creatorcontrib><description>Purpose
To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium‐based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF).
Materials and Methods
In the Zn supplementation study, rats were injected with Gadodiamide, Omniscan, and Magnevist with or without Zn supplementation. In the Zn depletion study, animals were kept on a Zn‐deficient diet or a special control diet and received injections of Omniscan, OptiMARK, Magnevist, Gadovist, and Gd‐EDTA. Gd, Zn, and Cu concentrations in tissue were measured and histology of the skin was performed.
Results
As seen in earlier studies, a difference in Gd concentration in the skin was observed following treatment with the different GBCAs. High Gd concentration in the skin correlated with the occurrence of NSF‐like skin lesions. We observed no differences in the occurrence of skin lesions between the Zn supplementation and the Zn‐deficient groups compared to their respective control groups.
Conclusion
We found no significant effect of Zn on the initiation of NSF‐like skin lesions. The results further support data from previous studies highlighting the importance of complex stability of the investigated GBCAs. J. Magn. Reson. Imaging 2009;30:374–383. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.21845</identifier><identifier>PMID: 19629978</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; complex stability ; Contrast Media - pharmacokinetics ; Contrast Media - toxicity ; Copper - metabolism ; Edetic Acid - pharmacokinetics ; Edetic Acid - toxicity ; gadolinium ; gadolinium based contrast agents (GBCAs) ; Gadolinium DTPA - pharmacokinetics ; Gadolinium DTPA - toxicity ; Nephrogenic Fibrosing Dermopathy - chemically induced ; nephrogenic systemic fibrosis (NSF) ; Organometallic Compounds - pharmacokinetics ; Organometallic Compounds - toxicity ; Rats ; Rats, Wistar ; Skin - metabolism ; Zinc - metabolism ; Zinc - pharmacology</subject><ispartof>Journal of magnetic resonance imaging, 2009-08, Vol.30 (2), p.374-383</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>(c) 2009 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4015-5cbc0eab8ed3d941fb178bbc51a83185b635ab68f0469d0244adf613487de6243</citedby><cites>FETCH-LOGICAL-c4015-5cbc0eab8ed3d941fb178bbc51a83185b635ab68f0469d0244adf613487de6243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.21845$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.21845$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19629978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pietsch, Hubertus</creatorcontrib><creatorcontrib>Pering, Christiane</creatorcontrib><creatorcontrib>Lengsfeld, Philipp</creatorcontrib><creatorcontrib>Walter, Jakob</creatorcontrib><creatorcontrib>Steger-Hartmann, Thomas</creatorcontrib><creatorcontrib>Golfier, Sven</creatorcontrib><creatorcontrib>Frenzel, Thomas</creatorcontrib><creatorcontrib>Hütter, Joachim</creatorcontrib><creatorcontrib>Weinmann, Hans-Joachim</creatorcontrib><creatorcontrib>Sieber, Martin A.</creatorcontrib><title>Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium‐based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF).
Materials and Methods
In the Zn supplementation study, rats were injected with Gadodiamide, Omniscan, and Magnevist with or without Zn supplementation. In the Zn depletion study, animals were kept on a Zn‐deficient diet or a special control diet and received injections of Omniscan, OptiMARK, Magnevist, Gadovist, and Gd‐EDTA. Gd, Zn, and Cu concentrations in tissue were measured and histology of the skin was performed.
Results
As seen in earlier studies, a difference in Gd concentration in the skin was observed following treatment with the different GBCAs. High Gd concentration in the skin correlated with the occurrence of NSF‐like skin lesions. We observed no differences in the occurrence of skin lesions between the Zn supplementation and the Zn‐deficient groups compared to their respective control groups.
Conclusion
We found no significant effect of Zn on the initiation of NSF‐like skin lesions. The results further support data from previous studies highlighting the importance of complex stability of the investigated GBCAs. J. Magn. Reson. Imaging 2009;30:374–383. © 2009 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>complex stability</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Contrast Media - toxicity</subject><subject>Copper - metabolism</subject><subject>Edetic Acid - pharmacokinetics</subject><subject>Edetic Acid - toxicity</subject><subject>gadolinium</subject><subject>gadolinium based contrast agents (GBCAs)</subject><subject>Gadolinium DTPA - pharmacokinetics</subject><subject>Gadolinium DTPA - toxicity</subject><subject>Nephrogenic Fibrosing Dermopathy - chemically induced</subject><subject>nephrogenic systemic fibrosis (NSF)</subject><subject>Organometallic Compounds - pharmacokinetics</subject><subject>Organometallic Compounds - toxicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Skin - metabolism</subject><subject>Zinc - metabolism</subject><subject>Zinc - pharmacology</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EoqVw4QFQzkgpdmI7DrdSlVLUAuJHSFws23HAbZpUdgKUpydpCtw47Wjn29FqADhGsI8gDM7mS2v6AWKY7IAuIkHgB4TR3VpDEvqIwagDDpybQwjjGJN90EExDeI4Yl3wMnoXWSVKk7965Zv2bJFpr0i9L5Mrz-SbXaFUZa3O1cZJjbSFM67RjesWJj_3Bt7KapWZ3CiRea6skvUh2EtF5vTRdvbA0-XocXjlT2_Hk-Fg6isMEfGJkgpqIZlOwiTGKJUoYlIqggQLESOShkRIylKIaZzAAGORpBSFmEWJpgEOe-C0zVX1X87qlK-sWQq75gjypiDeFMQ3BdXwSQuvKrnUyR-6baQGUAt8mEyv_4ni17P7yU-o394YV-rP3xthF5xGYUT4882YX9xNGXqghM_Cb-g2gAc</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Pietsch, Hubertus</creator><creator>Pering, Christiane</creator><creator>Lengsfeld, Philipp</creator><creator>Walter, Jakob</creator><creator>Steger-Hartmann, Thomas</creator><creator>Golfier, Sven</creator><creator>Frenzel, Thomas</creator><creator>Hütter, Joachim</creator><creator>Weinmann, Hans-Joachim</creator><creator>Sieber, Martin A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200908</creationdate><title>Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study</title><author>Pietsch, Hubertus ; Pering, Christiane ; Lengsfeld, Philipp ; Walter, Jakob ; Steger-Hartmann, Thomas ; Golfier, Sven ; Frenzel, Thomas ; Hütter, Joachim ; Weinmann, Hans-Joachim ; Sieber, Martin A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4015-5cbc0eab8ed3d941fb178bbc51a83185b635ab68f0469d0244adf613487de6243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>complex stability</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Contrast Media - toxicity</topic><topic>Copper - metabolism</topic><topic>Edetic Acid - pharmacokinetics</topic><topic>Edetic Acid - toxicity</topic><topic>gadolinium</topic><topic>gadolinium based contrast agents (GBCAs)</topic><topic>Gadolinium DTPA - pharmacokinetics</topic><topic>Gadolinium DTPA - toxicity</topic><topic>Nephrogenic Fibrosing Dermopathy - chemically induced</topic><topic>nephrogenic systemic fibrosis (NSF)</topic><topic>Organometallic Compounds - pharmacokinetics</topic><topic>Organometallic Compounds - toxicity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Skin - metabolism</topic><topic>Zinc - metabolism</topic><topic>Zinc - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pietsch, Hubertus</creatorcontrib><creatorcontrib>Pering, Christiane</creatorcontrib><creatorcontrib>Lengsfeld, Philipp</creatorcontrib><creatorcontrib>Walter, Jakob</creatorcontrib><creatorcontrib>Steger-Hartmann, Thomas</creatorcontrib><creatorcontrib>Golfier, Sven</creatorcontrib><creatorcontrib>Frenzel, Thomas</creatorcontrib><creatorcontrib>Hütter, Joachim</creatorcontrib><creatorcontrib>Weinmann, Hans-Joachim</creatorcontrib><creatorcontrib>Sieber, Martin A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pietsch, Hubertus</au><au>Pering, Christiane</au><au>Lengsfeld, Philipp</au><au>Walter, Jakob</au><au>Steger-Hartmann, Thomas</au><au>Golfier, Sven</au><au>Frenzel, Thomas</au><au>Hütter, Joachim</au><au>Weinmann, Hans-Joachim</au><au>Sieber, Martin A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2009-08</date><risdate>2009</risdate><volume>30</volume><issue>2</issue><spage>374</spage><epage>383</epage><pages>374-383</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium‐based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF).
Materials and Methods
In the Zn supplementation study, rats were injected with Gadodiamide, Omniscan, and Magnevist with or without Zn supplementation. In the Zn depletion study, animals were kept on a Zn‐deficient diet or a special control diet and received injections of Omniscan, OptiMARK, Magnevist, Gadovist, and Gd‐EDTA. Gd, Zn, and Cu concentrations in tissue were measured and histology of the skin was performed.
Results
As seen in earlier studies, a difference in Gd concentration in the skin was observed following treatment with the different GBCAs. High Gd concentration in the skin correlated with the occurrence of NSF‐like skin lesions. We observed no differences in the occurrence of skin lesions between the Zn supplementation and the Zn‐deficient groups compared to their respective control groups.
Conclusion
We found no significant effect of Zn on the initiation of NSF‐like skin lesions. The results further support data from previous studies highlighting the importance of complex stability of the investigated GBCAs. J. Magn. Reson. Imaging 2009;30:374–383. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19629978</pmid><doi>10.1002/jmri.21845</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2009-08, Vol.30 (2), p.374-383 |
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| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Animals complex stability Contrast Media - pharmacokinetics Contrast Media - toxicity Copper - metabolism Edetic Acid - pharmacokinetics Edetic Acid - toxicity gadolinium gadolinium based contrast agents (GBCAs) Gadolinium DTPA - pharmacokinetics Gadolinium DTPA - toxicity Nephrogenic Fibrosing Dermopathy - chemically induced nephrogenic systemic fibrosis (NSF) Organometallic Compounds - pharmacokinetics Organometallic Compounds - toxicity Rats Rats, Wistar Skin - metabolism Zinc - metabolism Zinc - pharmacology |
| title | Evaluating the role of zinc in the occurrence of fibrosis of the skin: A preclinical study |
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