Novel probes for imaging amyloid-β: F-18 and C-11 labeling of 2-(4-aminostyryl)benzoxazole derivatives

2‐(4‐Methylaminostyryl)‐6‐(2‐[18F]fluoroethoxy)benzoxazole ([18F]BF‐168) was prepared and found to be a potential probe for imaging amyloid‐β. The precursor, a 6‐(2‐tosyloxyethoxy)benzoxazole derivative, was fluorinated with [18F]KF and Kryptofix 222 in acetonitrile, and the crude product purified b...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2004-03, Vol.47 (3), p.181-190
Hauptverfasser:	Shimadzu, Hiroshi, Suemoto, Takahiro, Suzuki, Masako, Shiomitsu, Tsuyoshi, Okamura, Nobuyuki, Kudo, Yukitsuka, Sawada, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	2-(4-[N-methyl-11C]methylaminostyryl)-5-fluorobenzoxazole 2-(4-methylaminostyryl)-6-(2-[18F]fluoroethoxy)benzoxazole amyloid-β BF-145 BF-168 Biological and medical sciences Contrast media. Radiopharmaceuticals fluorine-18 Medical sciences PET Pharmacology. Drug treatments
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