Synthesis of tritium labelled L783483 - a PPARδ ligand
The potent peroxisome proliferator‐activated receptor (PPAR) δ ligand L783483 (3‐chloro‐4‐(3‐(7‐propyl‐3‐trifluoromethyl‐benzisoxazol‐6‐oxy)propylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5‐bromo‐6‐(3‐bromopropyloxy)‐7‐propyl‐3‐trifluorometh...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2003-04, Vol.46 (5), p.459-464 |
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| container_end_page | 464 |
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| container_issue | 5 |
| container_start_page | 459 |
| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 46 |
| creator | Grue-Sørensen, Gunnar Høj, Nicolaj |
| description | The potent peroxisome proliferator‐activated receptor (PPAR) δ ligand L783483 (3‐chloro‐4‐(3‐(7‐propyl‐3‐trifluoromethyl‐benzisoxazol‐6‐oxy)propylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5‐bromo‐6‐(3‐bromopropyloxy)‐7‐propyl‐3‐trifluoromethyl‐benzisoxazole. [3H]‐L783483 had a specific activity of 529 GBq/mmol (14.3 Ci/mmol) and a radiochemical purity of 98%. Copyright © 2003 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jlcr.687 |
| format | Article |
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[3H]‐L783483 had a specific activity of 529 GBq/mmol (14.3 Ci/mmol) and a radiochemical purity of 98%. Copyright © 2003 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.687</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; Contrast media. Radiopharmaceuticals ; L783483 ; Medical sciences ; Pharmacology. Drug treatments ; PPARδ ; tritium-bromine exchange</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2003-04, Vol.46 (5), p.459-464</ispartof><rights>Copyright © 2003 John Wiley & Sons, Ltd.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3657-edaf21526d6b574f90796605fdd9676e0fc8f6b1f3751859c7d8defdc3aaf3a33</citedby><cites>FETCH-LOGICAL-c3657-edaf21526d6b574f90796605fdd9676e0fc8f6b1f3751859c7d8defdc3aaf3a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjlcr.687$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjlcr.687$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14720434$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Grue-Sørensen, Gunnar</creatorcontrib><creatorcontrib>Høj, Nicolaj</creatorcontrib><title>Synthesis of tritium labelled L783483 - a PPARδ ligand</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Label Compd Radiopharm</addtitle><description>The potent peroxisome proliferator‐activated receptor (PPAR) δ ligand L783483 (3‐chloro‐4‐(3‐(7‐propyl‐3‐trifluoromethyl‐benzisoxazol‐6‐oxy)propylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5‐bromo‐6‐(3‐bromopropyloxy)‐7‐propyl‐3‐trifluoromethyl‐benzisoxazole. [3H]‐L783483 had a specific activity of 529 GBq/mmol (14.3 Ci/mmol) and a radiochemical purity of 98%. Copyright © 2003 John Wiley & Sons, Ltd.</description><subject>Biological and medical sciences</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>L783483</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>PPARδ</subject><subject>tritium-bromine exchange</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp1z8tKAzEYBeAgCtYq-AjZCG6mJpNMMlmWQasyaK23ZUhz0dT0QjKifS-fw2dyyhRdufoX_8fhHACOMRpghPKzWdBxwEq-A3oYCZFhQuku6CHC8oyWiOyDg5RmCLU_SnuA368XzatNPsGlg030jX-fw6CmNgRrYM1LQksCM6jgeDycfH_B4F_UwhyCPadCskfb2wePF-cP1WVW346uqmGdacIKnlmjXI6LnBk2LTh1AnHBGCqcMYJxZpHTpWNT7AgvcFkIzU1prDOaKOWIIqQPTrtcHZcpRevkKvq5imuJkdwMlpvBsh3c0pOOrlTSKrioFtqnP095jiihrcs69-GDXf-bJ6_ratLlbr1Pjf389Sq-Scbb3vL5ZiSZELXAd4V8Ij_WPHH-</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Grue-Sørensen, Gunnar</creator><creator>Høj, Nicolaj</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200304</creationdate><title>Synthesis of tritium labelled L783483 - a PPARδ ligand</title><author>Grue-Sørensen, Gunnar ; Høj, Nicolaj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3657-edaf21526d6b574f90796605fdd9676e0fc8f6b1f3751859c7d8defdc3aaf3a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>L783483</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>PPARδ</topic><topic>tritium-bromine exchange</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grue-Sørensen, Gunnar</creatorcontrib><creatorcontrib>Høj, Nicolaj</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grue-Sørensen, Gunnar</au><au>Høj, Nicolaj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of tritium labelled L783483 - a PPARδ ligand</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>2003-04</date><risdate>2003</risdate><volume>46</volume><issue>5</issue><spage>459</spage><epage>464</epage><pages>459-464</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>The potent peroxisome proliferator‐activated receptor (PPAR) δ ligand L783483 (3‐chloro‐4‐(3‐(7‐propyl‐3‐trifluoromethyl‐benzisoxazol‐6‐oxy)propylsulfanyl)phenylacetic acid) has been labelled with tritium via selective tritium/bromine exchange of 5‐bromo‐6‐(3‐bromopropyloxy)‐7‐propyl‐3‐trifluoromethyl‐benzisoxazole. [3H]‐L783483 had a specific activity of 529 GBq/mmol (14.3 Ci/mmol) and a radiochemical purity of 98%. Copyright © 2003 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jlcr.687</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of labelled compounds & radiopharmaceuticals, 2003-04, Vol.46 (5), p.459-464 |
| issn | 0362-4803 1099-1344 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Contrast media. Radiopharmaceuticals L783483 Medical sciences Pharmacology. Drug treatments PPARδ tritium-bromine exchange |
| title | Synthesis of tritium labelled L783483 - a PPARδ ligand |
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