Synthesis of deuterium‐labelled coenzyme Q 10
Deuterium‐labelled coenzyme Q 10 ([2‐CD 3 ‐1′‐CD 2 ]coenzyme Q 10 , coenzyme Q 10 ‐d 5 ) was synthesized by condensation of 2,3‐dimethoxy‐[5‐CD 3 ]methyl‐1, 4‐hydroquinone with [1‐CD 2 ]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination of...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2002-09, Vol.45 (10), p.831-839 |
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| container_title | Journal of labelled compounds & radiopharmaceuticals |
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| creator | Hamamura, Kimio Yamagishi, Yoji Kijima, Shizumasa Suzuki, Takeshi Mori, Yutaka Nakamura, Tetsuya |
| description | Deuterium‐labelled coenzyme Q
10
([2‐CD
3
‐1′‐CD
2
]coenzyme Q
10
, coenzyme Q
10
‐d
5
) was synthesized by condensation of 2,3‐dimethoxy‐[5‐CD
3
]methyl‐1, 4‐hydroquinone with [1‐CD
2
]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination of every step of the synthesis. This examination was carried out by a combination of
1
H‐ and
13
C‐nuclear magnetic spectrometry and mass spectrometry. Further, these positions have been proved to be metabolically stable. This reagent makes simultaneous quantification of the source of coenzyme Q
10
(exogenously supplied or endogenously supplied) possible in biological samples by measurements on gas chromatography–mass spectrometry. Copyright © 2002 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jlcr.587 |
| format | Article |
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10
([2‐CD
3
‐1′‐CD
2
]coenzyme Q
10
, coenzyme Q
10
‐d
5
) was synthesized by condensation of 2,3‐dimethoxy‐[5‐CD
3
]methyl‐1, 4‐hydroquinone with [1‐CD
2
]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination of every step of the synthesis. This examination was carried out by a combination of
1
H‐ and
13
C‐nuclear magnetic spectrometry and mass spectrometry. Further, these positions have been proved to be metabolically stable. This reagent makes simultaneous quantification of the source of coenzyme Q
10
(exogenously supplied or endogenously supplied) possible in biological samples by measurements on gas chromatography–mass spectrometry. Copyright © 2002 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.587</identifier><language>eng</language><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2002-09, Vol.45 (10), p.831-839</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c727-85d0cc9742b65faab780a9348d171883ae9fd98305eb3532a0020e6822b4493</citedby><cites>FETCH-LOGICAL-c727-85d0cc9742b65faab780a9348d171883ae9fd98305eb3532a0020e6822b4493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Hamamura, Kimio</creatorcontrib><creatorcontrib>Yamagishi, Yoji</creatorcontrib><creatorcontrib>Kijima, Shizumasa</creatorcontrib><creatorcontrib>Suzuki, Takeshi</creatorcontrib><creatorcontrib>Mori, Yutaka</creatorcontrib><creatorcontrib>Nakamura, Tetsuya</creatorcontrib><title>Synthesis of deuterium‐labelled coenzyme Q 10</title><title>Journal of labelled compounds & radiopharmaceuticals</title><description>Deuterium‐labelled coenzyme Q
10
([2‐CD
3
‐1′‐CD
2
]coenzyme Q
10
, coenzyme Q
10
‐d
5
) was synthesized by condensation of 2,3‐dimethoxy‐[5‐CD
3
]methyl‐1, 4‐hydroquinone with [1‐CD
2
]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination of every step of the synthesis. This examination was carried out by a combination of
1
H‐ and
13
C‐nuclear magnetic spectrometry and mass spectrometry. Further, these positions have been proved to be metabolically stable. This reagent makes simultaneous quantification of the source of coenzyme Q
10
(exogenously supplied or endogenously supplied) possible in biological samples by measurements on gas chromatography–mass spectrometry. Copyright © 2002 John Wiley & Sons, Ltd.</description><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNotz81KAzEUBeAgCo5V8BGydDPtzd8kWUpRKxSk1f2QSW5wykxHknYxrnwEn9EncYquzuLA4XyE3DKYMwC-2HU-zZXRZ6RgYG3JhJTnpABR8VIaEJfkKucdwNRJWZDF67g_vGNuMx0iDXg8YGqP_c_Xd-ca7DoM1A-4_xx7pBvK4JpcRNdlvPnPGdk-PrwtV-X65el5eb8uvea6NCqA91ZL3lQqOtdoA84KaQLTzBjh0MZgjQCFjVCCu-k5YGU4b6S0Ykbu_kZ9GnJOGOuP1PYujTWD-qSsT8p6UopfEHREsQ</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>Hamamura, Kimio</creator><creator>Yamagishi, Yoji</creator><creator>Kijima, Shizumasa</creator><creator>Suzuki, Takeshi</creator><creator>Mori, Yutaka</creator><creator>Nakamura, Tetsuya</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200209</creationdate><title>Synthesis of deuterium‐labelled coenzyme Q 10</title><author>Hamamura, Kimio ; Yamagishi, Yoji ; Kijima, Shizumasa ; Suzuki, Takeshi ; Mori, Yutaka ; Nakamura, Tetsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c727-85d0cc9742b65faab780a9348d171883ae9fd98305eb3532a0020e6822b4493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamamura, Kimio</creatorcontrib><creatorcontrib>Yamagishi, Yoji</creatorcontrib><creatorcontrib>Kijima, Shizumasa</creatorcontrib><creatorcontrib>Suzuki, Takeshi</creatorcontrib><creatorcontrib>Mori, Yutaka</creatorcontrib><creatorcontrib>Nakamura, Tetsuya</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamamura, Kimio</au><au>Yamagishi, Yoji</au><au>Kijima, Shizumasa</au><au>Suzuki, Takeshi</au><au>Mori, Yutaka</au><au>Nakamura, Tetsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of deuterium‐labelled coenzyme Q 10</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><date>2002-09</date><risdate>2002</risdate><volume>45</volume><issue>10</issue><spage>831</spage><epage>839</epage><pages>831-839</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>Deuterium‐labelled coenzyme Q
10
([2‐CD
3
‐1′‐CD
2
]coenzyme Q
10
, coenzyme Q
10
‐d
5
) was synthesized by condensation of 2,3‐dimethoxy‐[5‐CD
3
]methyl‐1, 4‐hydroquinone with [1‐CD
2
]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination of every step of the synthesis. This examination was carried out by a combination of
1
H‐ and
13
C‐nuclear magnetic spectrometry and mass spectrometry. Further, these positions have been proved to be metabolically stable. This reagent makes simultaneous quantification of the source of coenzyme Q
10
(exogenously supplied or endogenously supplied) possible in biological samples by measurements on gas chromatography–mass spectrometry. Copyright © 2002 John Wiley & Sons, Ltd.</abstract><doi>10.1002/jlcr.587</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-4803 |
| ispartof | Journal of labelled compounds & radiopharmaceuticals, 2002-09, Vol.45 (10), p.831-839 |
| issn | 0362-4803 1099-1344 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jlcr_587 |
| source | Wiley Online Library Journals Frontfile Complete |
| title | Synthesis of deuterium‐labelled coenzyme Q 10 |
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