Large‐scale preparation of 13 C‐labeled 2‐(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones
We have developed large‐scale efficient procedures for the conversion of commercially available [ 13 C]‐ or [ 2 H 3 , 13 C]methanol and 13 CO 2 or 13 C‐labeled bromoacetic acid to 2‐(phenylthio)[1,2‐ 13 C 2 ]‐, [1‐ 13 C]‐, and [2‐ 13 C]acetic acid. The resulting derivatives are versatile, chemically...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2013-02, Vol.56 (2), p.31-35 |
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| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 56 |
| creator | Martinez, Rodolfo A. Glass, David R. Ortiz, Erick G. Alvarez, Marc A. Juarez, Ernesto Lodwig, Siegfried N. Unkefer, Clifford J. |
| description | We have developed large‐scale efficient procedures for the conversion of commercially available [
13
C]‐ or [
2
H
3
,
13
C]methanol and
13
CO
2
or
13
C‐labeled bromoacetic acid to 2‐(phenylthio)[1,2‐
13
C
2
]‐, [1‐
13
C]‐, and [2‐
13
C]acetic acid. The resulting derivatives are versatile, chemically stable, and nonvolatile two‐carbon labeling precursors. We have used the
13
C‐isotopomers of 2‐(phenylthio)acetic acid in the synthesis of
13
C‐labeled acrylic acid, methacrylic acid, and
trans
‐crotonic acid. |
| doi_str_mv | 10.1002/jlcr.2991 |
| format | Article |
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13
C]‐ or [
2
H
3
,
13
C]methanol and
13
CO
2
or
13
C‐labeled bromoacetic acid to 2‐(phenylthio)[1,2‐
13
C
2
]‐, [1‐
13
C]‐, and [2‐
13
C]acetic acid. The resulting derivatives are versatile, chemically stable, and nonvolatile two‐carbon labeling precursors. We have used the
13
C‐isotopomers of 2‐(phenylthio)acetic acid in the synthesis of
13
C‐labeled acrylic acid, methacrylic acid, and
trans
‐crotonic acid.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.2991</identifier><language>eng</language><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2013-02, Vol.56 (2), p.31-35</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c741-71b2d58325497940eb08f98f314c33e75217c78e213468c24b48597b3d41fc73</citedby><cites>FETCH-LOGICAL-c741-71b2d58325497940eb08f98f314c33e75217c78e213468c24b48597b3d41fc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Martinez, Rodolfo A.</creatorcontrib><creatorcontrib>Glass, David R.</creatorcontrib><creatorcontrib>Ortiz, Erick G.</creatorcontrib><creatorcontrib>Alvarez, Marc A.</creatorcontrib><creatorcontrib>Juarez, Ernesto</creatorcontrib><creatorcontrib>Lodwig, Siegfried N.</creatorcontrib><creatorcontrib>Unkefer, Clifford J.</creatorcontrib><title>Large‐scale preparation of 13 C‐labeled 2‐(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones</title><title>Journal of labelled compounds & radiopharmaceuticals</title><description>We have developed large‐scale efficient procedures for the conversion of commercially available [
13
C]‐ or [
2
H
3
,
13
C]methanol and
13
CO
2
or
13
C‐labeled bromoacetic acid to 2‐(phenylthio)[1,2‐
13
C
2
]‐, [1‐
13
C]‐, and [2‐
13
C]acetic acid. The resulting derivatives are versatile, chemically stable, and nonvolatile two‐carbon labeling precursors. We have used the
13
C‐isotopomers of 2‐(phenylthio)acetic acid in the synthesis of
13
C‐labeled acrylic acid, methacrylic acid, and
trans
‐crotonic acid.</description><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNo1kM1KAzEUhYMoWKsL3yBLu5iav2mSpRT_oOBC90MmuWlT4mRIRrALwUfwGX0Sp1VX91zOuRfOh9AlJXNKCLveRpvnTGt6hCaUaF1RLsQxmhC-YJVQhJ-is1K2hIyeEBP0sTJ5Dd-fX8WaCLjP0JtshpA6nDymHC9HL5oWIjjMRn3Vb6DbxWET0sxYGILFxgaHTefwsAFsU85Q-tS50K3x_2V5iz69BwflEDysHZRzdOJNLHDxN6fo-e72ZflQrZ7uH5c3q8pKQStJW-ZqxVkttNSCQEuU18pzKiznIGtGpZUK2Nh1oSwTrVC1li13gnor-RTNfr_anErJ4Js-h1eTdw0lzZ5as6fW7KnxH94HY3o</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Martinez, Rodolfo A.</creator><creator>Glass, David R.</creator><creator>Ortiz, Erick G.</creator><creator>Alvarez, Marc A.</creator><creator>Juarez, Ernesto</creator><creator>Lodwig, Siegfried N.</creator><creator>Unkefer, Clifford J.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201302</creationdate><title>Large‐scale preparation of 13 C‐labeled 2‐(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones</title><author>Martinez, Rodolfo A. ; Glass, David R. ; Ortiz, Erick G. ; Alvarez, Marc A. ; Juarez, Ernesto ; Lodwig, Siegfried N. ; Unkefer, Clifford J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c741-71b2d58325497940eb08f98f314c33e75217c78e213468c24b48597b3d41fc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez, Rodolfo A.</creatorcontrib><creatorcontrib>Glass, David R.</creatorcontrib><creatorcontrib>Ortiz, Erick G.</creatorcontrib><creatorcontrib>Alvarez, Marc A.</creatorcontrib><creatorcontrib>Juarez, Ernesto</creatorcontrib><creatorcontrib>Lodwig, Siegfried N.</creatorcontrib><creatorcontrib>Unkefer, Clifford J.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez, Rodolfo A.</au><au>Glass, David R.</au><au>Ortiz, Erick G.</au><au>Alvarez, Marc A.</au><au>Juarez, Ernesto</au><au>Lodwig, Siegfried N.</au><au>Unkefer, Clifford J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large‐scale preparation of 13 C‐labeled 2‐(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><date>2013-02</date><risdate>2013</risdate><volume>56</volume><issue>2</issue><spage>31</spage><epage>35</epage><pages>31-35</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>We have developed large‐scale efficient procedures for the conversion of commercially available [
13
C]‐ or [
2
H
3
,
13
C]methanol and
13
CO
2
or
13
C‐labeled bromoacetic acid to 2‐(phenylthio)[1,2‐
13
C
2
]‐, [1‐
13
C]‐, and [2‐
13
C]acetic acid. The resulting derivatives are versatile, chemically stable, and nonvolatile two‐carbon labeling precursors. We have used the
13
C‐isotopomers of 2‐(phenylthio)acetic acid in the synthesis of
13
C‐labeled acrylic acid, methacrylic acid, and
trans
‐crotonic acid.</abstract><doi>10.1002/jlcr.2991</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-4803 |
| ispartof | Journal of labelled compounds & radiopharmaceuticals, 2013-02, Vol.56 (2), p.31-35 |
| issn | 0362-4803 1099-1344 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jlcr_2991 |
| source | Wiley Online Library Journals Frontfile Complete |
| title | Large‐scale preparation of 13 C‐labeled 2‐(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones |
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