14 Carbon monoxide made simple: novel approach to the generation, utilization, and scrubbing of 14 carbon monoxide
A new method is reported for the efficient generation of 14 CO that can be applied in transition metal‐catalyzed carbonylation reactions. 14 CO is produced by palladium‐catalyzed decarbonylation of the stable acid chloride, 14 COgen. When combined in a two‐chamber system, the produced 14 CO is incor...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2012-09, Vol.55 (11-12), p.411-418 |
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| container_end_page | 418 |
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| container_issue | 11-12 |
| container_start_page | 411 |
| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 55 |
| creator | LINDHARDT, Anders T SIMONSSEN, Roger TAANING, Rolf H GØGSIG, Thomas M NILSSON, Göran N STENHAGEN, Gunnar ELMORE, Charles S SKRYDSTRUP, Troels |
| description | A new method is reported for the efficient generation of
14
CO that can be applied in transition metal‐catalyzed carbonylation reactions.
14
CO is produced by palladium‐catalyzed decarbonylation of the stable acid chloride,
14
COgen. When combined in a two‐chamber system, the produced
14
CO is incorporated into the target molecule with high efficiency. As the carbonylation chemistry is performed under mild conditions, this allows the
14
C isotope to enter the synthesis into an advanced stage intermediate. The presented work includes two aminocarbonylations, one amidocarbonylation, and one carbonylative Suzuki–Miyaura coupling, all installing the
14
C isotope in the final step of the synthesis. Finally, the identification of a highly efficient scrubber for the safe trapping and removal of any leftover
14
CO is also disclosed. |
| doi_str_mv | 10.1002/jlcr.2962 |
| format | Article |
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14
CO that can be applied in transition metal‐catalyzed carbonylation reactions.
14
CO is produced by palladium‐catalyzed decarbonylation of the stable acid chloride,
14
COgen. When combined in a two‐chamber system, the produced
14
CO is incorporated into the target molecule with high efficiency. As the carbonylation chemistry is performed under mild conditions, this allows the
14
C isotope to enter the synthesis into an advanced stage intermediate. The presented work includes two aminocarbonylations, one amidocarbonylation, and one carbonylative Suzuki–Miyaura coupling, all installing the
14
C isotope in the final step of the synthesis. Finally, the identification of a highly efficient scrubber for the safe trapping and removal of any leftover
14
CO is also disclosed.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.2962</identifier><language>eng</language><publisher>Chichester: Wiley</publisher><subject>Biological and medical sciences ; Contrast media. Radiopharmaceuticals ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2012-09, Vol.55 (11-12), p.411-418</ispartof><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1047-e2ca73df56d57412f59dde95c9ed000b25657caa727f35b41971d180fbb94753</citedby><cites>FETCH-LOGICAL-c1047-e2ca73df56d57412f59dde95c9ed000b25657caa727f35b41971d180fbb94753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26631627$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>LINDHARDT, Anders T</creatorcontrib><creatorcontrib>SIMONSSEN, Roger</creatorcontrib><creatorcontrib>TAANING, Rolf H</creatorcontrib><creatorcontrib>GØGSIG, Thomas M</creatorcontrib><creatorcontrib>NILSSON, Göran N</creatorcontrib><creatorcontrib>STENHAGEN, Gunnar</creatorcontrib><creatorcontrib>ELMORE, Charles S</creatorcontrib><creatorcontrib>SKRYDSTRUP, Troels</creatorcontrib><title>14 Carbon monoxide made simple: novel approach to the generation, utilization, and scrubbing of 14 carbon monoxide</title><title>Journal of labelled compounds & radiopharmaceuticals</title><description>A new method is reported for the efficient generation of
14
CO that can be applied in transition metal‐catalyzed carbonylation reactions.
14
CO is produced by palladium‐catalyzed decarbonylation of the stable acid chloride,
14
COgen. When combined in a two‐chamber system, the produced
14
CO is incorporated into the target molecule with high efficiency. As the carbonylation chemistry is performed under mild conditions, this allows the
14
C isotope to enter the synthesis into an advanced stage intermediate. The presented work includes two aminocarbonylations, one amidocarbonylation, and one carbonylative Suzuki–Miyaura coupling, all installing the
14
C isotope in the final step of the synthesis. Finally, the identification of a highly efficient scrubber for the safe trapping and removal of any leftover
14
CO is also disclosed.</description><subject>Biological and medical sciences</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpVkE1LAzEQhoMoWKsH_0EuHgS35nPTeJNSP6Dgpfcln23KbrIkW1F_vVtaBC8zDPPOw_AAcIvRDCNEHnetyTMia3IGJhhJWWHK2DmYIFqTis0RvQRXpewQGneMTUDGDC5U1inCLsX0FayDnRpLCV3fuicY06droer7nJTZwiHBYevgxkWX1RBSfID7IbTh5zSoaGExea91iBuYPBz55j__Glx41RZ3c-pTsH5Zrhdv1erj9X3xvKoMRkxUjhglqPW8tlwwTDyX1jrJjXR2fF8TXnNhlBJEeMo1w1Jgi-fIay2Z4HQK7o9Yk1Mp2fmmz6FT-bvBqDm4ag6umoOrMXt3zPaqGNX6rKIJ5e-A1DXFNRH0F5RiajE</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>LINDHARDT, Anders T</creator><creator>SIMONSSEN, Roger</creator><creator>TAANING, Rolf H</creator><creator>GØGSIG, Thomas M</creator><creator>NILSSON, Göran N</creator><creator>STENHAGEN, Gunnar</creator><creator>ELMORE, Charles S</creator><creator>SKRYDSTRUP, Troels</creator><general>Wiley</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201209</creationdate><title>14 Carbon monoxide made simple: novel approach to the generation, utilization, and scrubbing of 14 carbon monoxide</title><author>LINDHARDT, Anders T ; SIMONSSEN, Roger ; TAANING, Rolf H ; GØGSIG, Thomas M ; NILSSON, Göran N ; STENHAGEN, Gunnar ; ELMORE, Charles S ; SKRYDSTRUP, Troels</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1047-e2ca73df56d57412f59dde95c9ed000b25657caa727f35b41971d180fbb94753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LINDHARDT, Anders T</creatorcontrib><creatorcontrib>SIMONSSEN, Roger</creatorcontrib><creatorcontrib>TAANING, Rolf H</creatorcontrib><creatorcontrib>GØGSIG, Thomas M</creatorcontrib><creatorcontrib>NILSSON, Göran N</creatorcontrib><creatorcontrib>STENHAGEN, Gunnar</creatorcontrib><creatorcontrib>ELMORE, Charles S</creatorcontrib><creatorcontrib>SKRYDSTRUP, Troels</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LINDHARDT, Anders T</au><au>SIMONSSEN, Roger</au><au>TAANING, Rolf H</au><au>GØGSIG, Thomas M</au><au>NILSSON, Göran N</au><au>STENHAGEN, Gunnar</au><au>ELMORE, Charles S</au><au>SKRYDSTRUP, Troels</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>14 Carbon monoxide made simple: novel approach to the generation, utilization, and scrubbing of 14 carbon monoxide</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><date>2012-09</date><risdate>2012</risdate><volume>55</volume><issue>11-12</issue><spage>411</spage><epage>418</epage><pages>411-418</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>A new method is reported for the efficient generation of
14
CO that can be applied in transition metal‐catalyzed carbonylation reactions.
14
CO is produced by palladium‐catalyzed decarbonylation of the stable acid chloride,
14
COgen. When combined in a two‐chamber system, the produced
14
CO is incorporated into the target molecule with high efficiency. As the carbonylation chemistry is performed under mild conditions, this allows the
14
C isotope to enter the synthesis into an advanced stage intermediate. The presented work includes two aminocarbonylations, one amidocarbonylation, and one carbonylative Suzuki–Miyaura coupling, all installing the
14
C isotope in the final step of the synthesis. Finally, the identification of a highly efficient scrubber for the safe trapping and removal of any leftover
14
CO is also disclosed.</abstract><cop>Chichester</cop><pub>Wiley</pub><doi>10.1002/jlcr.2962</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0362-4803 |
| ispartof | Journal of labelled compounds & radiopharmaceuticals, 2012-09, Vol.55 (11-12), p.411-418 |
| issn | 0362-4803 1099-1344 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jlcr_2962 |
| source | Access via Wiley Online Library |
| subjects | Biological and medical sciences Contrast media. Radiopharmaceuticals Medical sciences Pharmacology. Drug treatments |
| title | 14 Carbon monoxide made simple: novel approach to the generation, utilization, and scrubbing of 14 carbon monoxide |
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