Preparation of 6‐azauracil‐5‐ 3 H and 6‐azauridine‐5‐ 3 H of high molar activity

Catalytic reductive dehalogenation of 5‐bromo‐6‐azauracil with carrier‐free tritium led to 6‐azauracil‐5‐ 3 H of a molar activity of 19.0 Ci/mmole. The reaction conditions for the catalytic reductive dehalogenation were examined in tracer experiments. Microbial transformation was used for the prepar...

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Veröffentlicht in:Journal of labelled compounds 1974-01, Vol.10 (1), p.59-71
Hauptverfasser: Filip, Jiri, Skoda, Jan, Hradec, Hynek
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creator Filip, Jiri
Skoda, Jan
Hradec, Hynek
description Catalytic reductive dehalogenation of 5‐bromo‐6‐azauracil with carrier‐free tritium led to 6‐azauracil‐5‐ 3 H of a molar activity of 19.0 Ci/mmole. The reaction conditions for the catalytic reductive dehalogenation were examined in tracer experiments. Microbial transformation was used for the preparation of 6‐azauridine‐5‐ 3 H from 6‐azauracil‐5‐ 3 H. 6‐Azauridine‐5‐ 3 ‐ H was prepared at a molar activity of 18.8 Ci/mmole. In both compounds the stability of tritium was investigated in an aqueous medium at 100°C.
doi_str_mv 10.1002/jlcr.2590100108
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title Preparation of 6‐azauracil‐5‐ 3 H and 6‐azauridine‐5‐ 3 H of high molar activity
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