Synthesis of [18F]-Fluoroethylfenoterol for imaging β2 receptor status in lung in vivo
5‐(‐{2‐[4‐(2‐[18F]Fluoroethoxy)‐phenyl]‐l‐methyl‐ethylamino}‐l‐hydroxy‐ethyl)‐benzene‐1, 3‐diol ([18F]fluoroethylfenoterol) was synthesised from 4‐(2‐{benzyl‐[2‐(3,5‐bis‐benzyloxy‐phenyl)‐2‐hydroxy‐ethyl]‐amino}‐propyl)‐phenol using 2‐[18F]fluoroethyltosylate (92% RCY) followed by reductive cleavage...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2001-05, Vol.44 (S1), p.S436-S438 |
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| container_end_page | S438 |
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| container_issue | S1 |
| container_start_page | S436 |
| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 44 |
| creator | Schirrmacher, E. Schirrmacher, R. Buhl, R. Wessler, I. Machulla, H.-J. Rösch, F. |
| description | 5‐(‐{2‐[4‐(2‐[18F]Fluoroethoxy)‐phenyl]‐l‐methyl‐ethylamino}‐l‐hydroxy‐ethyl)‐benzene‐1, 3‐diol ([18F]fluoroethylfenoterol) was synthesised from 4‐(2‐{benzyl‐[2‐(3,5‐bis‐benzyloxy‐phenyl)‐2‐hydroxy‐ethyl]‐amino}‐propyl)‐phenol using 2‐[18F]fluoroethyltosylate (92% RCY) followed by reductive cleavage of the benzyl protecting groups. Preliminary in vitro tests showed [19F]fluoroethylfenoterol to be as potent in relaxation of lung tissue as fenoterol itself. |
| doi_str_mv | 10.1002/jlcr.25804401154 |
| format | Article |
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Preliminary in vitro tests showed [19F]fluoroethylfenoterol to be as potent in relaxation of lung tissue as fenoterol itself.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.25804401154</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>18F ; fenoterol ; lung ; β2 adrenergic receptor</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2001-05, Vol.44 (S1), p.S436-S438</ispartof><rights>Copyright © 2001 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1334-ff27c30061b2b7b2b3935239d7883093b4ebe9ca112a45177387c03c5e88a863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjlcr.25804401154$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjlcr.25804401154$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Schirrmacher, E.</creatorcontrib><creatorcontrib>Schirrmacher, R.</creatorcontrib><creatorcontrib>Buhl, R.</creatorcontrib><creatorcontrib>Wessler, I.</creatorcontrib><creatorcontrib>Machulla, H.-J.</creatorcontrib><creatorcontrib>Rösch, F.</creatorcontrib><title>Synthesis of [18F]-Fluoroethylfenoterol for imaging β2 receptor status in lung in vivo</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Label Compd Radiopharm</addtitle><description>5‐(‐{2‐[4‐(2‐[18F]Fluoroethoxy)‐phenyl]‐l‐methyl‐ethylamino}‐l‐hydroxy‐ethyl)‐benzene‐1, 3‐diol ([18F]fluoroethylfenoterol) was synthesised from 4‐(2‐{benzyl‐[2‐(3,5‐bis‐benzyloxy‐phenyl)‐2‐hydroxy‐ethyl]‐amino}‐propyl)‐phenol using 2‐[18F]fluoroethyltosylate (92% RCY) followed by reductive cleavage of the benzyl protecting groups. Preliminary in vitro tests showed [19F]fluoroethylfenoterol to be as potent in relaxation of lung tissue as fenoterol itself.</description><subject>18F</subject><subject>fenoterol</subject><subject>lung</subject><subject>β2 adrenergic receptor</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkMFKw0AQhhdRsFbvHvcFUmd3NtnNwYNGW5WiUAs9iCxJ3LSpMSu7aTWv5YP4TKZURE8ehh_mn2_4-Qk5ZjBgAPxkWeVuwEMFQgBjodghPQZxHDAUYpf0ACMeCAW4Tw68XwJ0nhA9Mrtv62ZhfOmpLegDU8PHYFitrLOmWbRVYWrbGGcrWlhHy5d0XtZz-vnBqTO5eW26pW_SZuVpWdNq1Xmdrsu1PSR7RVp5c_StfTIdXk6Tq2B8N7pOzsZBzhBFUBRc5ggQsYxnshuMMeQYP0mlEGLMhMlMnKeM8VSETEpUMgfMQ6NUqiLsE9i-zZ313plCv7oupWs1A73pRW960b966ZDTLfJWVqb9917fjJPJXz7Y8qVvzPsPn7pnHUmUoZ7djnQs5QWfTM91gl9kfXfU</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Schirrmacher, E.</creator><creator>Schirrmacher, R.</creator><creator>Buhl, R.</creator><creator>Wessler, I.</creator><creator>Machulla, H.-J.</creator><creator>Rösch, F.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200105</creationdate><title>Synthesis of [18F]-Fluoroethylfenoterol for imaging β2 receptor status in lung in vivo</title><author>Schirrmacher, E. ; Schirrmacher, R. ; Buhl, R. ; Wessler, I. ; Machulla, H.-J. ; Rösch, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1334-ff27c30061b2b7b2b3935239d7883093b4ebe9ca112a45177387c03c5e88a863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>18F</topic><topic>fenoterol</topic><topic>lung</topic><topic>β2 adrenergic receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schirrmacher, E.</creatorcontrib><creatorcontrib>Schirrmacher, R.</creatorcontrib><creatorcontrib>Buhl, R.</creatorcontrib><creatorcontrib>Wessler, I.</creatorcontrib><creatorcontrib>Machulla, H.-J.</creatorcontrib><creatorcontrib>Rösch, F.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schirrmacher, E.</au><au>Schirrmacher, R.</au><au>Buhl, R.</au><au>Wessler, I.</au><au>Machulla, H.-J.</au><au>Rösch, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of [18F]-Fluoroethylfenoterol for imaging β2 receptor status in lung in vivo</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>2001-05</date><risdate>2001</risdate><volume>44</volume><issue>S1</issue><spage>S436</spage><epage>S438</epage><pages>S436-S438</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>5‐(‐{2‐[4‐(2‐[18F]Fluoroethoxy)‐phenyl]‐l‐methyl‐ethylamino}‐l‐hydroxy‐ethyl)‐benzene‐1, 3‐diol ([18F]fluoroethylfenoterol) was synthesised from 4‐(2‐{benzyl‐[2‐(3,5‐bis‐benzyloxy‐phenyl)‐2‐hydroxy‐ethyl]‐amino}‐propyl)‐phenol using 2‐[18F]fluoroethyltosylate (92% RCY) followed by reductive cleavage of the benzyl protecting groups. Preliminary in vitro tests showed [19F]fluoroethylfenoterol to be as potent in relaxation of lung tissue as fenoterol itself.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jlcr.25804401154</doi><tpages>3</tpages></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | 18F fenoterol lung β2 adrenergic receptor |
| title | Synthesis of [18F]-Fluoroethylfenoterol for imaging β2 receptor status in lung in vivo |
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