A facile synthesis of [14C]enadoline [(5R)-(5α, 7α,8β)]-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5] DEC-8-YL]-4-benzofuranacetamide

4‐Chloromethylbenzofuran (10) was synthesized from 2,3‐dimethylanisole in 7 steps. The corresponding Grignard reagent prepared from magnesium‐anthracene complex reacts with 14CO2, SOCl2, and PD130812 successively to give [14C]enadoline (2), a non‐peptide, selective kappa opioid receptor agonist. Thi...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1995-12, Vol.36 (12), p.1183-1191
Hauptverfasser:	Pu, Yu-Ming, Scripko, James, Huang, Che C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesic C-14 Label Chemistry Enadoline Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Opioid Receptors Organic chemistry Preparations and properties
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