Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)

2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐11C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [11C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was puri...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1993-02, Vol.33 (2), p.147-152
Hauptverfasser:	Dannals, Robert F., Neumeyer, John L., Milius, Richard A., Ravert, Hayden T., Wilson, Alan A., Wagner Jr, Henry N.
Format:	Artikel
Sprache:	eng
Schlagworte:	carbon-11 Chemistry dopamine uptake sites Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Organic chemistry positron emission tomography Preparations and properties radiotracer synthesis
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