Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)
2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐11C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [11C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was puri...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 1993-02, Vol.33 (2), p.147-152 |
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| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 33 |
| creator | Dannals, Robert F. Neumeyer, John L. Milius, Richard A. Ravert, Hayden T. Wilson, Alan A. Wagner Jr, Henry N. |
| description | 2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐11C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [11C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 3065 mCi/μmole (calculated at the end‐of‐synthesis; EOS). The average time of synthesis including formulation was approximately 21 minutes. |
| doi_str_mv | 10.1002/jlcr.2580330209 |
| format | Article |
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After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 3065 mCi/μmole (calculated at the end‐of‐synthesis; EOS). The average time of synthesis including formulation was approximately 21 minutes.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.2580330209</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>carbon-11 ; Chemistry ; dopamine uptake sites ; Exact sciences and technology ; Heterocyclic compounds ; Heterocyclic compounds with only one n hetero atom and condensed derivatives ; Organic chemistry ; positron emission tomography ; Preparations and properties ; radiotracer ; synthesis</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 1993-02, Vol.33 (2), p.147-152</ispartof><rights>Copyright © 1993 John Wiley & Sons, Ltd.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2739-6a95676a71141caced9a46b23c1b728e19028e0a0714cd355ba2bef176fe334b3</citedby><cites>FETCH-LOGICAL-c2739-6a95676a71141caced9a46b23c1b728e19028e0a0714cd355ba2bef176fe334b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjlcr.2580330209$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjlcr.2580330209$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4553639$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Dannals, Robert F.</creatorcontrib><creatorcontrib>Neumeyer, John L.</creatorcontrib><creatorcontrib>Milius, Richard A.</creatorcontrib><creatorcontrib>Ravert, Hayden T.</creatorcontrib><creatorcontrib>Wilson, Alan A.</creatorcontrib><creatorcontrib>Wagner Jr, Henry N.</creatorcontrib><title>Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Label Compd Radiopharm</addtitle><description>2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐11C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [11C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 3065 mCi/μmole (calculated at the end‐of‐synthesis; EOS). The average time of synthesis including formulation was approximately 21 minutes.</description><subject>carbon-11</subject><subject>Chemistry</subject><subject>dopamine uptake sites</subject><subject>Exact sciences and technology</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with only one n hetero atom and condensed derivatives</subject><subject>Organic chemistry</subject><subject>positron emission tomography</subject><subject>Preparations and properties</subject><subject>radiotracer</subject><subject>synthesis</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNqFkM1u1DAUhS0EEkPpmq0XLFoJt_5LMoEVjdpSNExRO2gWVWXdOA7jNhNHdqY0r8SSB-GZcJiqiFU3tnXP-c6VD0JvGD1glPLDm0b7A55MqRCU0_wZmjCa54QJKZ-jCRUpJzKKL9GrEG4ojZqUE_Tzcmj7lQk2YFdjwB4q63oP2nhcO49Dv6kG237HletgbVuDN10PtwYH25uAbYvv7J3DmzB6vh4v3mP--xfR4Eu3Nv3K3Q9ExMGeJHWzcd51K9MOzT65mhPGCjJ6hua6jwLE7L2rOLwuThY4rv77Xp7NiUjeST7df41e1NAEs_tw76BvJ8eL4hOZnZ-eFR9nRPNM5CSFPEmzFDLGJNPxI1UOMi250KzM-NSwnMaTAs2Y1JVIkhJ4aWqWpbURQpZiBx1uc7V3IXhTq87bNfhBMarGqtVYtfpXdSTebokOgoam9tBqGx4xmSQiFaPtw9b2wzZmeCpVfZ4VF_8tIVvaht7cP9Lgb1WaiSxRy_mpOloeXcrZl4W6EH8AWNSgMQ</recordid><startdate>199302</startdate><enddate>199302</enddate><creator>Dannals, Robert F.</creator><creator>Neumeyer, John L.</creator><creator>Milius, Richard A.</creator><creator>Ravert, Hayden T.</creator><creator>Wilson, Alan A.</creator><creator>Wagner Jr, Henry N.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199302</creationdate><title>Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)</title><author>Dannals, Robert F. ; Neumeyer, John L. ; Milius, Richard A. ; Ravert, Hayden T. ; Wilson, Alan A. ; Wagner Jr, Henry N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2739-6a95676a71141caced9a46b23c1b728e19028e0a0714cd355ba2bef176fe334b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>carbon-11</topic><topic>Chemistry</topic><topic>dopamine uptake sites</topic><topic>Exact sciences and technology</topic><topic>Heterocyclic compounds</topic><topic>Heterocyclic compounds with only one n hetero atom and condensed derivatives</topic><topic>Organic chemistry</topic><topic>positron emission tomography</topic><topic>Preparations and properties</topic><topic>radiotracer</topic><topic>synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dannals, Robert F.</creatorcontrib><creatorcontrib>Neumeyer, John L.</creatorcontrib><creatorcontrib>Milius, Richard A.</creatorcontrib><creatorcontrib>Ravert, Hayden T.</creatorcontrib><creatorcontrib>Wilson, Alan A.</creatorcontrib><creatorcontrib>Wagner Jr, Henry N.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dannals, Robert F.</au><au>Neumeyer, John L.</au><au>Milius, Richard A.</au><au>Ravert, Hayden T.</au><au>Wilson, Alan A.</au><au>Wagner Jr, Henry N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>1993-02</date><risdate>1993</risdate><volume>33</volume><issue>2</issue><spage>147</spage><epage>152</epage><pages>147-152</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐11C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [11C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 3065 mCi/μmole (calculated at the end‐of‐synthesis; EOS). The average time of synthesis including formulation was approximately 21 minutes.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jlcr.2580330209</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0362-4803 |
| ispartof | Journal of labelled compounds & radiopharmaceuticals, 1993-02, Vol.33 (2), p.147-152 |
| issn | 0362-4803 1099-1344 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jlcr_2580330209 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | carbon-11 Chemistry dopamine uptake sites Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Organic chemistry positron emission tomography Preparations and properties radiotracer synthesis |
| title | Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428) |
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