Stereoselective Synthesis of Stable Isotope Labeled L-α-Amino Acids: Synthesis of L−[4−13C] and L−[3,4−13C2]Aspartic Acid

We have developed a stereoselective route to isotopically labeled L‐aspartic acid using L‐serine as a chiral precursor. Labeled serine, prepared biosynthetically was N‐protected by conversion to the N‐t‐Boc derivative. (N‐t‐Boc)‐[3−13C]Serine is cyclized to its β‐lactone which was treated with potas...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1992-02, Vol.31 (2), p.95-102
Hauptverfasser:	Lodwig, Siegfried N., Unkefer, Clifford J.
Format:	Artikel
Sprache:	eng
Schlagworte:	4−13C2]Aspartic Acid L-[3−13C]serine L-[4−13C]Aspartic Acid L‐[3,4−13C2]Aspartic Acid
Online-Zugang:	Volltext
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