Synthesis of the muscle relaxant [14C]L-637,510

The synthesis of (E)‐3‐(9‐chloro‐5,6‐dihydro‐1 1 H‐pyrrolo(2,1‐b)(3)‐benzazepin‐11‐ylidene)‐N, N‐dimethyl‐1‐[3‐14C]‐propanamine (Z)‐2‐butenedioate(1:1) (11, [14C]L‐637,510), a potential muscle relaxant product for which 14C‐labeling was required for metabolism studies, is described. Introduction of...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1991-07, Vol.29 (7), p.791-796
Hauptverfasser:	O'Connor, Stephen P., Ellsworth, Robert L., Gatto, Gregory, Sharp, Merck, Dohme
Format:	Artikel
Sprache:	eng
Schlagworte:	(E)‐3‐(9‐Chloro‐5,6‐dihydro‐11 H‐pyrrolo(2,1‐b) ‐benzazepin‐1 1‐ylidene)‐N, N‐dimethyl‐1‐[3‐14C]propanamine (Z)‐2‐butenedioate (1:1) 1-b) -benzazepin-1 1-ylidene)-N 1-b)-benzazepin-1 1-one 6-dihydro-11 H-pyrrolo 9-chloro-5 9‐chloro‐5,6‐dihydro‐11 H‐pyrrolo(2,1‐b)‐benzazepin‐1 1‐one E)-3-(9-Chloro-5 N-dimethyl-1-[3-14C]propanamine (Z)-2-butenedioate (1:1)
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