Preparation of 4,4′-diaminodiphenylmethane-(2H4) for use as internal standard in the quantification of 4,4′-diaminodiphenylmethane
A simple method has been developed for the synthesis of 4,4′‐diaminodiphenylmethane‐(2H4) for analytical purposes in gas chromatography‐negative ion chemical ionization mass spectrometry (GC‐NICIMS). It consists in a proton‐deuterium exchange reaction of the diamine using deutero‐hydrochloric acid i...
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| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 1991-06, Vol.29 (6), p.725-728 |
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| container_end_page | 728 |
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| container_issue | 6 |
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| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 29 |
| creator | Natangelo, Marco Bagnati, Renzo Fanelli, Roberto Gavinelli, Marco Ulbricht, Claudia Benfenati, Emilio |
| description | A simple method has been developed for the synthesis of 4,4′‐diaminodiphenylmethane‐(2H4) for analytical purposes in gas chromatography‐negative ion chemical ionization mass spectrometry (GC‐NICIMS). It consists in a proton‐deuterium exchange reaction of the diamine using deutero‐hydrochloric acid in deuterated methanol. The reaction was conducted at 60°C. Deuteration of the diamine in the ortho positions of the aromatic rings was observed after eight days in these conditions, using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. |
| doi_str_mv | 10.1002/jlcr.2580290614 |
| format | Article |
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It consists in a proton‐deuterium exchange reaction of the diamine using deutero‐hydrochloric acid in deuterated methanol. The reaction was conducted at 60°C. Deuteration of the diamine in the ortho positions of the aromatic rings was observed after eight days in these conditions, using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.2580290614</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>4,4′‐diaminodiphenylmethane‐(2H4) ; 4′-diaminodiphenylmethane-(2H4) ; gas chromatography-negative ion chemical ionization mass spectrometry ; proton-deuterium exchange reaction</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 1991-06, Vol.29 (6), p.725-728</ispartof><rights>Copyright © 1991 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1984-5f7aba2a33a848ef3afe3e42f0c0af60d0ec6dceb2216db75c1353c77db57f3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjlcr.2580290614$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjlcr.2580290614$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Natangelo, Marco</creatorcontrib><creatorcontrib>Bagnati, Renzo</creatorcontrib><creatorcontrib>Fanelli, Roberto</creatorcontrib><creatorcontrib>Gavinelli, Marco</creatorcontrib><creatorcontrib>Ulbricht, Claudia</creatorcontrib><creatorcontrib>Benfenati, Emilio</creatorcontrib><title>Preparation of 4,4′-diaminodiphenylmethane-(2H4) for use as internal standard in the quantification of 4,4′-diaminodiphenylmethane</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Label Compd Radiopharm</addtitle><description>A simple method has been developed for the synthesis of 4,4′‐diaminodiphenylmethane‐(2H4) for analytical purposes in gas chromatography‐negative ion chemical ionization mass spectrometry (GC‐NICIMS). It consists in a proton‐deuterium exchange reaction of the diamine using deutero‐hydrochloric acid in deuterated methanol. The reaction was conducted at 60°C. Deuteration of the diamine in the ortho positions of the aromatic rings was observed after eight days in these conditions, using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.</description><subject>4,4′‐diaminodiphenylmethane‐(2H4)</subject><subject>4′-diaminodiphenylmethane-(2H4)</subject><subject>gas chromatography-negative ion chemical ionization mass spectrometry</subject><subject>proton-deuterium exchange reaction</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNqNkLtOAkEUhidGExGtbafUxIW57YVYGVCQEG_BSDc5OzsTBpddnFmidFY-kI_kk7gEo7HS6iT_-b-_-BA6pKRFCWHtWa5ci4UJYR0SUbGFGpR0OgHlQmyjBuERC0RC-C7a835GSP0TooHebpxegIPKlgUuDRYn4uP1PcgszG1RZnYx1cUqn-tqCoUOjthAHGNTOrz0GoPHtqi0KyDHvoIiA5fVCa6mGj8toaissep_y_tox0Du9cHXbaL7i_NxdxCMrvuX3bNRoGgnEUFoYkiBAeeQiEQbDkZzLZghioCJSEa0ijKlU8ZolKVxqCgPuYrjLA3jus2bqL3ZVa703mkjF87Owa0kJXKtUa41yh-NNXG6IZ5trld_1eVw1L37RQcb2vpKv3zT4B5lFPM4lA9XfTme9G67vclQ9vknZ3qL6Q</recordid><startdate>199106</startdate><enddate>199106</enddate><creator>Natangelo, Marco</creator><creator>Bagnati, Renzo</creator><creator>Fanelli, Roberto</creator><creator>Gavinelli, Marco</creator><creator>Ulbricht, Claudia</creator><creator>Benfenati, Emilio</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199106</creationdate><title>Preparation of 4,4′-diaminodiphenylmethane-(2H4) for use as internal standard in the quantification of 4,4′-diaminodiphenylmethane</title><author>Natangelo, Marco ; Bagnati, Renzo ; Fanelli, Roberto ; Gavinelli, Marco ; Ulbricht, Claudia ; Benfenati, Emilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1984-5f7aba2a33a848ef3afe3e42f0c0af60d0ec6dceb2216db75c1353c77db57f3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>4,4′‐diaminodiphenylmethane‐(2H4)</topic><topic>4′-diaminodiphenylmethane-(2H4)</topic><topic>gas chromatography-negative ion chemical ionization mass spectrometry</topic><topic>proton-deuterium exchange reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Natangelo, Marco</creatorcontrib><creatorcontrib>Bagnati, Renzo</creatorcontrib><creatorcontrib>Fanelli, Roberto</creatorcontrib><creatorcontrib>Gavinelli, Marco</creatorcontrib><creatorcontrib>Ulbricht, Claudia</creatorcontrib><creatorcontrib>Benfenati, Emilio</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Natangelo, Marco</au><au>Bagnati, Renzo</au><au>Fanelli, Roberto</au><au>Gavinelli, Marco</au><au>Ulbricht, Claudia</au><au>Benfenati, Emilio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of 4,4′-diaminodiphenylmethane-(2H4) for use as internal standard in the quantification of 4,4′-diaminodiphenylmethane</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>1991-06</date><risdate>1991</risdate><volume>29</volume><issue>6</issue><spage>725</spage><epage>728</epage><pages>725-728</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>A simple method has been developed for the synthesis of 4,4′‐diaminodiphenylmethane‐(2H4) for analytical purposes in gas chromatography‐negative ion chemical ionization mass spectrometry (GC‐NICIMS). It consists in a proton‐deuterium exchange reaction of the diamine using deutero‐hydrochloric acid in deuterated methanol. The reaction was conducted at 60°C. Deuteration of the diamine in the ortho positions of the aromatic rings was observed after eight days in these conditions, using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jlcr.2580290614</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0362-4803 |
| ispartof | Journal of labelled compounds & radiopharmaceuticals, 1991-06, Vol.29 (6), p.725-728 |
| issn | 0362-4803 1099-1344 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jlcr_2580290614 |
| source | Wiley Journals |
| subjects | 4,4′‐diaminodiphenylmethane‐(2H4) 4′-diaminodiphenylmethane-(2H4) gas chromatography-negative ion chemical ionization mass spectrometry proton-deuterium exchange reaction |
| title | Preparation of 4,4′-diaminodiphenylmethane-(2H4) for use as internal standard in the quantification of 4,4′-diaminodiphenylmethane |
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