Preparation of no-carrier-added 4-[131i]iodoantipyrine using chloramine-T

The blood flow reagent 4‐iodoantipyrine, labelled with 131I or 125I, was prepared by allowing aqueous antipyrine to react with either no‐carrier‐added 131I−I or 125I−I in the presence of chloramine‐T. Purification of 4‐[131I]iodoantipyrine was performed by reversed‐phase liquid chromatography and re...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1986-05, Vol.23 (5), p.479-485
Hauptverfasser: Boothe, Thomas E., Finn, Ronald D., Vora, Manhar M., Kothari, J Paresh, Emran, Ali M.
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container_end_page 485
container_issue 5
container_start_page 479
container_title Journal of labelled compounds & radiopharmaceuticals
container_volume 23
creator Boothe, Thomas E.
Finn, Ronald D.
Vora, Manhar M.
Kothari, J Paresh
Emran, Ali M.
description The blood flow reagent 4‐iodoantipyrine, labelled with 131I or 125I, was prepared by allowing aqueous antipyrine to react with either no‐carrier‐added 131I−I or 125I−I in the presence of chloramine‐T. Purification of 4‐[131I]iodoantipyrine was performed by reversed‐phase liquid chromatography and resulted in a 99 ± 1% radiochemically pure product in an overall 90% yield. The use of iodogen for oxidation of the radioiodine was also investigated.
doi_str_mv 10.1002/jlcr.2580230504
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Purification of 4‐[131I]iodoantipyrine was performed by reversed‐phase liquid chromatography and resulted in a 99 ± 1% radiochemically pure product in an overall 90% yield. 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The use of iodogen for oxidation of the radioiodine was also investigated.</description><subject>4-[125I]lodoantipyrine</subject><subject>4-[131I]lodoantipyrine</subject><subject>Chloramine-T</subject><subject>Iodogen</subject><subject>No-Carrier-Added 131I− and 125I</subject><subject>Reversed-Phase Liquid Chromatography</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqFkMFKAzEQhoMoWKtnr_sCaSeZbLOLJ1m0thSVUlEUCWk2q6nbTUkq2rd3S0Xx5Glg5v-Gn4-QUwY9BsD7i9qEHk8z4AgpiD3SYZDnlKEQ-6QDOOBUZICH5CjGBUB7E6JDRrfBrnTQa-ebxFdJ46nRITgbqC5LWyaCPjFk7tn50utm7Vab4BqbvEfXvCTmtfZBL9sFnR2Tg0rX0Z58zy65u7yYFVd0cjMcFecTapDngnLMhGay4qBlWwKEzPJMC0TUEtHMWWkRmMC5Hpi2I7OZsNYawXjJq1Ra7JL-7q8JPsZgK7UKbqnDRjFQWxNqa0L9mmiJsx3x4Wq7-S-uxpNi-oemO9rFtf38oXV4UwOJMlX310PFivFjPoUHNcYvPgxxSw</recordid><startdate>198605</startdate><enddate>198605</enddate><creator>Boothe, Thomas E.</creator><creator>Finn, Ronald D.</creator><creator>Vora, Manhar M.</creator><creator>Kothari, J Paresh</creator><creator>Emran, Ali M.</creator><general>John Wiley &amp; Sons, Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198605</creationdate><title>Preparation of no-carrier-added 4-[131i]iodoantipyrine using chloramine-T</title><author>Boothe, Thomas E. ; Finn, Ronald D. ; Vora, Manhar M. ; Kothari, J Paresh ; Emran, Ali M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3294-2384a17f20a7009047898a4333a733cb1de30143ba6c0991e84eeec412d2f57e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>4-[125I]lodoantipyrine</topic><topic>4-[131I]lodoantipyrine</topic><topic>Chloramine-T</topic><topic>Iodogen</topic><topic>No-Carrier-Added 131I− and 125I</topic><topic>Reversed-Phase Liquid Chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boothe, Thomas E.</creatorcontrib><creatorcontrib>Finn, Ronald D.</creatorcontrib><creatorcontrib>Vora, Manhar M.</creatorcontrib><creatorcontrib>Kothari, J Paresh</creatorcontrib><creatorcontrib>Emran, Ali M.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds &amp; radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boothe, Thomas E.</au><au>Finn, Ronald D.</au><au>Vora, Manhar M.</au><au>Kothari, J Paresh</au><au>Emran, Ali M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation of no-carrier-added 4-[131i]iodoantipyrine using chloramine-T</atitle><jtitle>Journal of labelled compounds &amp; radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>1986-05</date><risdate>1986</risdate><volume>23</volume><issue>5</issue><spage>479</spage><epage>485</epage><pages>479-485</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>The blood flow reagent 4‐iodoantipyrine, labelled with 131I or 125I, was prepared by allowing aqueous antipyrine to react with either no‐carrier‐added 131I−I or 125I−I in the presence of chloramine‐T. 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identifier ISSN: 0362-4803
ispartof Journal of labelled compounds & radiopharmaceuticals, 1986-05, Vol.23 (5), p.479-485
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language eng
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source Wiley Online Library All Journals
subjects 4-[125I]lodoantipyrine
4-[131I]lodoantipyrine
Chloramine-T
Iodogen
No-Carrier-Added 131I− and 125I
Reversed-Phase Liquid Chromatography
title Preparation of no-carrier-added 4-[131i]iodoantipyrine using chloramine-T
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