Synthesis of specifically-deuterated procaine and tetracaine

Synthesis of specifically-deuterated procaine and tetracaine

Local anesthetics procaine and tetracaine have been specifically‐deuterated in two and three positions, respectively, for use in deuterium nuclear magnetic resonance experiments. The experimental procedure is either new or an adaptation of early synthetic methods.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1981-08, Vol.18 (8), p.1197-1204
Hauptverfasser: Boulanger, Yvan, Leitcht, Leonard C.
Format: Artikel
Sprache:eng
Schlagworte:
Anesthetic
Deuterium
NMR
NMR, nuclear magnetic resonance
nuclear magnetic resonance
PRC
PRC, procaine
Procaine
Tetracaine
TTC
TTC, tetracaine
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Beschreibung
Zusammenfassung:Local anesthetics procaine and tetracaine have been specifically‐deuterated in two and three positions, respectively, for use in deuterium nuclear magnetic resonance experiments. The experimental procedure is either new or an adaptation of early synthetic methods.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580180815