A modified approach to C-14-labeled 2-(3,4-difluorophenoxy)-5-fluoronicotinic acid and other halogen-substituted analogs

A modified approach to a carbon‐14‐labeled pyridine ring system was developed based on the electrocyclic ring‐closure of 1,4,4‐trisubstituted butadiene. The new method was applied to prepare 2‐(3,4‐difluorophenoxy)‐5‐fluoro‐[2‐14C] nicotinic acid and other halogen‐substituted analogs. The targeted c...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2011-06, Vol.54 (7), p.382-386
Hauptverfasser:	Zhang, Yinsheng, Jian, Zhigang, Stolle, Wayne T.
Format:	Artikel
Sprache:	eng
Schlagworte:	aryl ether formation Biological and medical sciences carbon-14 Contrast media. Radiopharmaceuticals Medical sciences nicotinic acid Pharmacology. Drug treatments pyridine ring formation
Online-Zugang:	Volltext
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